CAS 486-21-5

Isofraxidin

Description:

Isofraxidin, with the CAS number 486-21-5, is a chemical compound classified as a flavonoid, specifically a methoxyflavone. It is primarily derived from various plant sources, particularly from the roots of certain species in the genus *Angelica*. Isofraxidin is known for its potential pharmacological properties, including anti-inflammatory, antioxidant, and vasodilatory effects. The compound exhibits a yellowish crystalline appearance and is soluble in organic solvents, such as ethanol and methanol, but has limited solubility in water. Isofraxidin has garnered interest in the field of medicinal chemistry due to its potential therapeutic applications, particularly in cardiovascular health and as a natural remedy in traditional medicine. Its mechanism of action may involve the modulation of various biochemical pathways, contributing to its beneficial effects. However, further research is necessary to fully elucidate its pharmacokinetics, safety profile, and efficacy in clinical settings.

Formula: C₁₁H₁₀O₅

InChI: InChI=1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)11(15-2)9(7)13/h3-5,13H,1-2H3

InChI key: InChIKey=HOEVRHHMDJKUMZ-UHFFFAOYSA-N

SMILES: O(C)C1=C2C(=CC(OC)=C1O)C=CC(=O)O2

Synonyms:

• 2H-1-Benzopyran-2-one, 7-hydroxy-6,8-dimethoxy-
• 6,8-Dimethoxy-7-hydroxycoumarin
• 7-Hydroxy-6,8-dimethoxy-2H-1-benzopyran-2-one
• 7-Hydroxy-6,8-dimethoxychromen-2-one
• 7-hydroxy-6,8-dimethoxy-2H-chromen-2-one
• Coumarin, 7-hydroxy-6,8-dimethoxy-
• NSC 324637
• Phytodolor
• Umbelliferone, 6,8-dimethoxy-
• Isofraxidin

7-Hydroxy-6,8-dimethoxy-2H-1-benzopyran-2-one

CAS: 486-21-5

Formula: C₁₁H₁₀O₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 222.1941

Ref: IN-DA003927

Isofraxidin

CAS: 486-21-5

Isofraxidin

Purity: ≥95%

Molecular weight: 222.19g/mol

Ref: 54-BUP11390

7-Hydroxy-6,8-Dimethoxy-2H-Chromen-2-One

CAS: 486-21-5

7-Hydroxy-6,8-Dimethoxy-2H-Chromen-2-One

Purity: 99%

Molecular weight: 222.19g/mol

Ref: 54-OR1024099

Isofraxidin

CAS: 486-21-5

Formula: C₁₁H₁₀O₅

Molecular weight: 222.20

Ref: 7W-GY4993

Isofraxidin

CAS: 486-21-5

Isofraxidin has definite anti-bacterial, anti-oxidant, analgesic,and anti-inflammatory activities, it inhibits expression of MMP-7 and in vitro cell invasion at a non-toxic level through inhibiting ERK1/2 phosphorylation in hepatoma cell lines.Isofraxidin is one possible radio-protector, it can protect leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner.

Formula: C₁₁H₁₀O₅

Purity: 95%~99%

Molecular weight: 222.196

Ref: BP-BP0783

Isofraxidin

CAS: 486-21-5

Isofraxidin combats leukemia, ALI, and inflammation by modulating ROS, COX-2, PGE2, TNF-α, and p38/ERK1/2 pathways.

Formula: C₁₁H₁₀O₅

Purity: 99.51% - ≥95%

Color and Shape: Solid

Molecular weight: 222.19

Ref: TM-T5S0045

Isofraxidin

CAS: 486-21-5

Lactone

Formula: C₁₁H₁₀O₅

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 222.2

Ref: 5G-89229

Isofraxidin

CAS: 486-21-5

Isofraxidin is a natural compound, classified as a coumarin, which is derived from a variety of plant species, including certain members of the Artemisia or Acanthopanax genus. Its chemical structure is characterized by a 7-hydroxy-6,8-dimethoxy derivative that contributes to its pharmacological properties.

Formula: C₁₁H₁₀O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 222.19 g/mol

Ref: 3D-FI65562

ISOFRAXIDIN

CAS: 486-21-5

Purity: 95%

Molecular weight: 222.1959991

Ref: 10-F814480