CAS 486-56-6

Cotinine

Description:

Cotinine is a naturally occurring alkaloid and a major metabolite of nicotine, primarily found in tobacco. It is classified as a pyridine derivative and has a molecular formula of C10H12N2O. Cotinine is typically a colorless to pale yellow liquid with a characteristic odor and is soluble in water, alcohol, and organic solvents. Its structure features a pyridine ring, which contributes to its pharmacological properties. Cotinine is often used as a biomarker for tobacco exposure due to its relatively long half-life compared to nicotine, making it useful in studies related to smoking cessation and tobacco use. The substance exhibits mild psychoactive effects and has been studied for its potential therapeutic applications, including neuroprotective properties. Additionally, cotinine has been investigated for its role in modulating the effects of nicotine on the central nervous system. Safety data indicate that cotinine has low toxicity, but its effects can vary based on dosage and individual sensitivity.

Formula: C₁₀H₁₂N₂O

InChI: InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

InChI key: InChIKey=UIKROCXWUNQSPJ-VIFPVBQESA-N

SMILES: CN1[C@@H](CCC1=O)C=2C=CC=NC2

Synonyms:

• (5R)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
• (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
• (5S)-1-Methyl-5-pyridin-3-ylpyrrolidin-2-one
• (5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
• (S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone
• (S)-Cotinine
• 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)-
• 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-
• Cotinin
• Cotinina
• Nih 10498
• Cotinine

S-(-)-Cotinine (1.0 mg/mL in Methanol)

CAS: 486-56-6

Formula: C₁₀H₁₂N₂O

Ref: TR-TRC-KIT0540-1ML

S-(-)-Cotinine

CAS: 486-56-6

Cotinine is a metabolite of nicotine that is found in the blood. It is used as a biomarker for exposure to tobacco products and has been shown to be an independent risk factor for cardiovascular disease. Cotinine can be detected in the blood, plasma, saliva, urine and breast milk with detection times of 24 hours to one week. Cotinine can also be measured in hair samples with detection times of 80 days or more. The measurement of cotinine levels in biological samples is complicated by the presence of other metabolites from nicotine metabolism and its high affinity for proteins such as albumin. It is important to account for these confounding factors when interpreting results from cotinine measurements. The most common method used to measure cotinine levels in biological samples is liquid chromatography-mass spectrometry (LC-MS/MS). This analytical method uses a mass spectrometer to separate and identify molecules based on their mass-to-charge ratio. A mouse monoclonal antibody

Formula: C₁₀H₁₂N₂O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 176.22 g/mol

Ref: 3D-FC20565