CAS 486460-23-5

1,1-Dimethylethyl N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]carbamate

Description:

1,1-Dimethylethyl N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]carbamate, with CAS number 486460-23-5, is a complex organic compound characterized by its unique structural features, including a carbamate functional group and multiple fluorinated aromatic rings. This compound exhibits significant biological activity, often studied for its potential applications in pharmaceuticals, particularly in the development of novel therapeutic agents. The presence of trifluoromethyl groups enhances its lipophilicity and metabolic stability, which can influence its pharmacokinetic properties. Additionally, the triazole and pyrazine moieties contribute to its potential as a bioactive molecule, possibly interacting with specific biological targets. The compound's synthesis typically involves multi-step organic reactions, highlighting its complexity. As with many fluorinated compounds, it may exhibit unique solubility and reactivity characteristics, making it of interest in both medicinal chemistry and materials science. Safety and handling considerations are essential due to the presence of fluorinated groups, which can pose environmental and health risks.

Formula: C₂₁H₂₃F₆N₅O₃

InChI: InChI=1S/C21H23F6N5O3/c1-20(2,3)35-19(34)28-12(6-11-7-14(23)15(24)9-13(11)22)8-17(33)31-4-5-32-16(10-31)29-30-18(32)21(25,26)27/h7,9,12H,4-6,8,10H2,1-3H3,(H,28,34)/t12-/m1/s1

InChI key: InChIKey=RHCVXZBZEKGRQP-GFCCVEGCSA-N

SMILES: C(F)(F)(F)C=1N2C(CN(C(C[C@@H](CC3=C(F)C=C(F)C(F)=C3)NC(OC(C)(C)C)=O)=O)CC2)=NN1

Synonyms:

• 1,1-Dimethylethyl N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]carbamate
• Boc-Sitagliptin
• Carbamic acid, N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester
• Carbamic acid, [(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester
• N-BOC-Sitagliptin
• Sitagliptin N-Boc
• tert-Butyl [(R)-4-oxo-4-(3-trifluoromethyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl]carbamate

Sitagliptin N-Boc IMpurity

CAS: 486460-23-5

Formula: C₂₁H₂₃F₆N₅O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 507.4294

Ref: IN-DA00DETC

N-Boc-Sitagliptin

CAS: 486460-23-5

Formula: C₂₁H₂₃F₆N₅O₃

Color and Shape: White To Off-White Solid

Molecular weight: 507.44

Ref: 4Z-S-2026

N-Boc-Sitagliptin

CAS: 486460-23-5

N-Boc-Sitagliptin

Purity: ≥95%

Molecular weight: 507.43g/mol

Ref: 54-PC110546

N-Boc-Sitagliptin

CAS: 486460-23-5

Color and Shape: Neat

Ref: 86-MM3378.11

N-Boc-Sitagliptin

Controlled Product

CAS: 486460-23-5

Applications N-Boc-Sitagliptin is the N-Boc protected derivative of Sitagliptin (S490990), a dipeptidyl peptidase-4 inhibitor that is used for glycemic control for patients with type 2 diabetes.
References Aschner, P., et al.: Diabetes Care, 29, 2632 (2006); Charbonnel, B., et al.: Diabetes Care, 29, 2638 (2006)

Formula: C₂₁H₂₃F₆N₅O₃

Color and Shape: Neat

Molecular weight: 507.43

Ref: TR-B667500

Sitagliptin impurity D

CAS: 486460-23-5

Please enquire for more information about Sitagliptin impurity D including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₂₁H₂₃F₆N₅O₃

Purity: Min. 95%

Molecular weight: 507.43 g/mol

Ref: 3D-FS175065

Sitagliptin Impurity 18

CAS: 486460-23-5

Formula: C₂₁H₂₃F₆N₅O₃

Molecular weight: 507.44

Ref: ST-EA-CP-S3022