CAS 486460-32-6

Sitagliptin

Description:

Sitagliptin is an oral antihyperglycemic agent primarily used in the management of type 2 diabetes mellitus. It belongs to the class of drugs known as DPP-4 inhibitors, which work by increasing the levels of incretin hormones, thereby enhancing insulin secretion in response to meals and reducing glucagon secretion. The chemical formula of sitagliptin is C16H15F6N5O2S, and it features a unique structure that includes a 2-(4-(trifluoromethyl)phenyl) group and a 1,2,4-triazole moiety. Sitagliptin is typically administered in tablet form and is known for its favorable safety profile, with common side effects including gastrointestinal disturbances and potential risk of pancreatitis. It is often prescribed as part of a comprehensive diabetes management plan, which may include lifestyle modifications and other antidiabetic medications. The drug is generally well-tolerated and can be used alone or in combination with other agents to achieve better glycemic control.

Formula: C₁₆H₁₅F₆N₅O

InChI: InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1

InChI key: InChIKey=MFFMDFFZMYYVKS-SECBINFHSA-N

SMILES: C(F)(F)(F)C=1N2C(CN(C(C[C@@H](CC3=C(F)C=C(F)C(F)=C3)N)=O)CC2)=NN1

Synonyms:

• (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
• (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• (3R)-3-Amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• (3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone
• (3S)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• 1,2,4-Triazolo(4,3-a)pyrazine, 7-((3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydor-3-(trifluoromethyl)-
• 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-
• 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-
• 3(R)-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
• Ristaben
• Sitagliptin Base
• Sitagliptin Intermediate
• Sitagliptin free base
• Sitagliptine
• Tesavel
• Xelevia

Sitagliptin

CAS: 486460-32-6

Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.

Formula: C₁₆H₁₅F₆N₅O

Purity: 99.33% - 99.83%

Color and Shape: Yellow Grease

Molecular weight: 407.31

Ref: TM-T0242

Sitagliptin

CAS: 486460-32-6

Formula: C₁₆H₁₅F₆N₅O

Color and Shape: White To Off-White Solid

Molecular weight: 407.32

Ref: 4Z-S-201

Sitagliptin

CAS: 486460-32-6

Sitagliptin

Purity: 98%

Molecular weight: 407.32g/mol

Ref: 54-PC109185

Sitagliptin

CAS: 486460-32-6

Sitagliptin

Purity: ≥98%

Molecular weight: 407.31g/mol

Ref: 54-BUP16086

Sitagliptin

CAS: 486460-32-6

Formula: C₁₆H₁₅F₆N₅O

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 407.32

Ref: 3B-I1261

Sitagliptin

CAS: 486460-32-6

Formula: C₁₆H₁₅F₆N₅O

Color and Shape: Neat

Molecular weight: 407.31

Ref: 04-C16970820

(3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

CAS: 486460-32-6

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 407.32000732421875

Ref: 10-F358083

Sitagliptin 100 µg/mL in Acetonitrile

CAS: 486460-32-6

Formula: C₁₆H₁₅F₆N₅O

Color and Shape: Single Solution

Molecular weight: 407.31

Ref: 04-A16970820AL-100

Sitagliptin

CAS: 486460-32-6

Formula: C₁₆H₁₅F₆N₅O

Purity: ≥ 98.0%

Color and Shape: White to off-white or yellow-beige powder

Molecular weight: 407.31

Ref: 7W-GP8640

Sitagliptin-d4

CAS: 1432063-88-1, 486460-32-6

Formula: C₁₆H₁₁F₆N₅OD₄

Molecular weight: 411.35

Ref: 4Z-S-202

Sitagliptin Impurity 103

CAS: 486459-71-6, 486460-32-6

Formula: C₆H₉ClN₄

Color and Shape: White To Off-White Solid

Molecular weight: 172.62

Ref: 4Z-S-20132

Sitagliptin

Controlled Product

CAS: 486460-32-6

Applications Sitagliptin (cas# 486460-32-6) is a useful research chemical.

Formula: C₁₆H₁₅F₆N₅O

Color and Shape: Off-White

Molecular weight: 407.31

Ref: TR-S491035

Sitagliptin

CAS: 486460-32-6

Inhibitor of dipeptidyl-peptidase; anti-diabetic agent

Formula: C₁₆H₁₅F₆N₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 407.31 g/mol

Ref: 3D-FA31666

4-Desfluoro-destrifluoromethyl Sitagliptin Hydrochloride Salt

Controlled Product

CAS: 486460-32-6

Formula: C₁₅H₁₇F₂N₅O·HCl

Color and Shape: Neat

Molecular weight: 357.786

Ref: TR-D290585

5-Desfluoro-destrifluoromethyl Sitagliptin Hydrochloride Salt

Controlled Product

CAS: 486460-32-6

Formula: C₁₅H₁₇F₂N₅O·HCl

Color and Shape: Neat

Molecular weight: 357.786

Ref: TR-D290580