CAS 486460-32-6: Sitagliptin

Description: Sitagliptin is an oral antihyperglycemic agent primarily used in the management of type 2 diabetes mellitus. It belongs to the class of drugs known as DPP-4 inhibitors, which work by increasing the levels of incretin hormones, thereby enhancing insulin secretion in response to meals and reducing glucagon secretion. The chemical formula of sitagliptin is C16H15F6N5O2S, and it features a unique structure that includes a 2-(4-(trifluoromethyl)phenyl) group and a 1,2,4-triazole moiety. Sitagliptin is typically administered in tablet form and is known for its favorable safety profile, with common side effects including gastrointestinal disturbances and potential risk of pancreatitis. It is often prescribed as part of a comprehensive diabetes management plan, which may include lifestyle modifications and other antidiabetic medications. The drug is generally well-tolerated and can be used alone or in combination with other agents to achieve better glycemic control.

Formula: C₁₆H₁₅F₆N₅O

InChI: InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1

InChI key: InChIKey=MFFMDFFZMYYVKS-SECBINFHSA-N

SMILES: O=C(N1CC2=NN=C(N2CC1)C(F)(F)F)CC(N)CC3=CC(F)=C(F)C=C3F

Synonyms:

• (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
• (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• (3R)-3-Amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• (3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone
• (3S)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• 1,2,4-Triazolo(4,3-a)pyrazine, 7-((3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydor-3-(trifluoromethyl)-
• 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-
• 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-
• 3(R)-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
• Ristaben
• Sitagliptin Base
• Sitagliptin Intermediate
• Sitagliptin free base
• Sitagliptine
• Tesavel
• Xelevia
• Sitagliptin

Sitagliptin

CAS: 486460-32-6

Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by …

• Formula: C₁₆H₁₅F₆N₅O
• Purity: 99.33% - 99.4%
• Color and Shape: Yellow Grease
• Molecular weight: 407.31

Sitagliptin

CAS: 486460-32-6

• Formula: C₁₆H₁₅F₆N₅O
• Color and Shape: White To Off-White Solid
• Molecular weight: 407.32

Sitagliptin Impurity 103

CAS: 486459-71-6 486460-32-6

• Formula: C₆H₉ClN₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 172.62

Sitagliptin

CAS: 486460-32-6

• Purity: 98%
• Molecular weight: 407.32g/mol

(3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

CAS: 486460-32-6

• Purity: 98.0%
• Color and Shape: Solid
• Molecular weight: 407.32000732421875

Sitagliptin

CAS: 486460-32-6

• Formula: C₁₆H₁₅F₆N₅O
• Color and Shape: Neat
• Molecular weight: 407.31

Sitagliptin

CAS: 486460-32-6

• Formula: C₁₆H₁₅F₆N₅O
• Purity: >95.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 407.32

Sitagliptin 100 µg/mL in Acetonitrile

CAS: 486460-32-6

• Formula: C₁₆H₁₅F₆N₅O
• Color and Shape: Single Solution
• Molecular weight: 407.31

Sitagliptin-d4

CAS: 1432063-88-1 486460-32-6

• Formula: C₁₆H₁₁F₆N₅OD₄
• Molecular weight: 411.35

Sitagliptin

CAS: 486460-32-6

• Formula: C₁₆H₁₅F₆N₅O
• Purity: ≥ 98.0%
• Color and Shape: White to off-white or yellow-beige powder
• Molecular weight: 407.31

Sitagliptin

CAS: 486460-32-6

Applications Sitagliptin (cas# 486460-32-6) is a useful research chemical.

• Formula: C₁₆H₁₅F₆N₅O
• Color and Shape: Off-White
• Molecular weight: 407.31

Sitagliptin

CAS: 486460-32-6

Inhibitor of dipeptidyl-peptidase; anti-diabetic agent

• Formula: C₁₆H₁₅F₆N₅O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 407.31 g/mol

4-Desfluoro-destrifluoromethyl Sitagliptin Hydrochloride Salt

CAS: 486460-32-6

• Formula: C₁₅H₁₇F₂N₅O·HCl
• Color and Shape: Neat
• Molecular weight: 357.786

5-Desfluoro-destrifluoromethyl Sitagliptin Hydrochloride Salt

CAS: 486460-32-6

• Formula: C₁₅H₁₇F₂N₅O·HCl
• Color and Shape: Neat
• Molecular weight: 357.786