CAS 487-79-6

α-Kainic acid

Description:

α-Kainic acid is a naturally occurring amino acid derivative and a potent neuroactive compound primarily derived from the seaweed species of the genus *Digenea*. It is classified as a glutamate analog and is known for its role as an excitatory neurotransmitter in the central nervous system. The chemical structure of α-Kainic acid features a pyrrolidine ring, which contributes to its biological activity. It is characterized by its ability to selectively bind to and activate certain glutamate receptors, particularly the kainate subtype, influencing synaptic transmission and neuronal excitability. This compound has been extensively studied for its neuropharmacological properties and potential applications in understanding neurodegenerative diseases and epilepsy. Additionally, α-Kainic acid is utilized in research to induce excitotoxicity in animal models, providing insights into neuronal damage mechanisms. Its solubility in water and stability under physiological conditions make it a valuable tool in neuroscience research. However, due to its potent effects, careful handling and dosage considerations are essential in experimental settings.

Formula: C₁₀H₁₅NO₄

InChI: InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

InChI key: InChIKey=VLSMHEGGTFMBBZ-OOZYFLPDSA-N

SMILES: C(C(O)=O)[C@H]1[C@@H](C(C)=C)CN[C@@H]1C(O)=O

Synonyms:

• (-)-α-Kainic acid
• (2-Carboxy-4-isopropenyl-3-pyrrolidinyl)-essigsaeure anhydrous
• (2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
• (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic acid
• (3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-yl-L-proline
• 3-(Carboxymethyl)-4-Prop-1-En-2-Ylproline
• 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-
• 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, [2S-(2α,3β,4β)]-
• 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl-
• <span class="text-smallcaps">L</span>-α-Kainic acid
• Digenic acid
• Digenin
• Helminal

3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-

CAS: 487-79-6

Formula: C₁₀H₁₅NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 213.2304

Ref: IN-DA01CC0Q

Kainic acid

CAS: 487-79-6

Kainic acid

Purity: ≥98%

Molecular weight: 213.23g/mol

Ref: 54-BUP16345

Kainic Acid

CAS: 487-79-6

M02036 - Kainic Acid

Formula: C₁₀H₁₅NO₄

Purity: >99%

Color and Shape: Solid

Molecular weight: 213.233

Ref: 10-M02036

Kainic acid

CAS: 487-79-6

Kainic acid is an excitatory amino acid receptor agonist (EC50=16.2 μM). Kainic acid is an effective excitatory toxic agent. High-Quality, Low-Cost!

Formula: C₁₀H₁₅NO₄

Purity: 98.47% - >99.99%

Color and Shape: White Solid

Molecular weight: 213.23

Ref: TM-T15643

(-)-α-Kainic Acid Lithium Salt

Controlled Product

CAS: 487-79-6

Applications (-)-α-Kainic Acid Lithium Salt is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
References Wacker, D.A., et al.: Synlett, 503 (1997), Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)’

Formula: C₁₀H₁₄LiNO₄

Color and Shape: Neat

Molecular weight: 219.163

Ref: TR-K135015

(-)-alpha-Kainic Acid

Controlled Product

CAS: 487-79-6

Applications (-)-α-Kainic Acid is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
References Wacker, D.A., et al.: Synlett, 503 (1997), Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)’

Formula: C₁₀H₁₅NO₄

Color and Shape: Neat

Molecular weight: 213.23

Ref: TR-K135010

Kainic Acid

CAS: 487-79-6

Kainic Acid is a potent neuroexcitant, which is derived from certain species of red algae such as Digenea simplex. It acts as an agonist of kainate receptors, a subtype of ionotropic glutamate receptors, leading to excitotoxicity through the influx of calcium ions and the overactivation of neuronal circuits. Kainic Acid's ability to induce seizures by mimicking the neurotransmitter glutamate makes it an invaluable tool in neuroscientific research.

Formula: C₁₀H₁₅NO₄

Purity: Min. 95%

Molecular weight: 213.23 g/mol

Ref: 3D-AAA48779