CAS 488-04-0

Holomycin

Description:

Holomycin, with the CAS number 488-04-0, is a naturally occurring antibiotic that belongs to the class of compounds known as polyketides. It is produced by certain strains of the bacterium *Streptomyces* and exhibits significant antibacterial properties, particularly against Gram-positive bacteria. Holomycin is characterized by its complex molecular structure, which includes multiple functional groups that contribute to its biological activity. The compound is known to inhibit bacterial protein synthesis, making it effective in treating various bacterial infections. Additionally, Holomycin has been studied for its potential applications in agriculture as a fungicide and in the development of new therapeutic agents. Its solubility and stability in different solvents can vary, which is important for its formulation and application. As with many antibiotics, the emergence of resistance is a concern, prompting ongoing research into its mechanisms of action and potential modifications to enhance its efficacy. Overall, Holomycin represents a significant compound in the field of microbiology and medicinal chemistry.

Formula: C₇H₆N₂O₂S₂

InChI: InChI=1S/C7H6N2O2S2/c1-3(10)8-5-6-4(2-12-13-6)9-7(5)11/h2H,1H3,(H,8,10)(H,9,11)

InChI key: InChIKey=HBUNPJGMNVQSBX-UHFFFAOYSA-N

SMILES: N(C(C)=O)C1=C2C(NC1=O)=CSS2

Synonyms:

• 1,2-Dithiolo[4,3-b]pyrrol-5(4H)-one, 6-(acetylamino)-
• 1,2-Dithiolo[4,3-b]pyrrol-5(4H)-one, 6-acetamido-
• 1,2-Dithiolo[4,3-b]pyrrole, acetamide deriv.
• 488-04-0
• Holomycin
• N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
• acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-
• N-(5-Oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide

Holomycin

CAS: 488-04-0

Holomycin

Purity: ≥98%

Molecular weight: 214.26g/mol

Ref: 54-BUP11965

Holomycin

Controlled Product

CAS: 488-04-0

Stability Hygroscopic
Applications Holomycin is a member of the pyrrothine class of antibiotics and displays broad-spectrum antibacterial activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Oliva, B., et al.: Antimicrob. Agents Ch., 45, 532 (2001); Scharf, Daniel H., et al.: J. Microbiol. Biotechn., 24, 26 (2014); Zotchev, Sergey B.: J. Biol. Chem., 288, 14688 (2013); Kenig, M., et al.: J. Antib., 32, 549 (1979)

Formula: C₇H₆N₂O₂S₂

Color and Shape: Neat

Molecular weight: 214.26

Ref: TR-H458490

Holomycin-d3

Controlled Product

CAS: 488-04-0

Applications Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity.
References Oliva, B., et al.: Antimicrob. Agents Ch., 45, 532 (2001); Scharf, Daniel H., et al.: J. Microbiol. Biotechn., 24, 26 (2014); Zotchev, Sergey B.: J. Biol. Chem., 288, 14688 (2013)

Formula: C₇H₃D₃N₂O₂S₂

Color and Shape: Neat

Molecular weight: 217.28

Ref: TR-H458492

Holomycin

CAS: 488-04-0

Holomycin, a dithiopyrrolidone antibiotic, promotes S2753 biofilm formation and has broad-spectrum antibacterial and antitumor properties.

Formula: C₇H₆N₂O₂S₂

Purity: 98.76%

Color and Shape: Soild

Molecular weight: 214.26

Ref: TM-T67731