CAS 488832-69-5

Elesclomol

Description:

Elesclomol is a synthetic small molecule that has garnered attention for its potential as an anti-cancer agent. It functions primarily as an oxidative stress inducer, selectively targeting cancer cells by enhancing their oxidative metabolism, which can lead to apoptosis. Elesclomol is characterized by its ability to increase reactive oxygen species (ROS) levels within tumor cells, thereby exploiting the heightened oxidative stress that many cancer cells experience. This mechanism is thought to be particularly effective in certain types of cancers, including melanoma. The compound is typically administered intravenously and has been studied in various clinical trials to evaluate its efficacy and safety profile. In terms of chemical properties, Elesclomol is a lipophilic compound, which influences its distribution and bioavailability in biological systems. Its development has been associated with both monotherapy and combination therapy approaches, aiming to enhance the therapeutic outcomes in cancer treatment. However, further research is ongoing to fully understand its mechanisms and optimize its clinical applications.

Formula: C₁₉H₂₀N₄O₂S₂

InChI: InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)

InChI key: InChIKey=BKJIXTWSNXCKJH-UHFFFAOYSA-N

SMILES: C(N(NC(CC(NN(C(=S)C1=CC=CC=C1)C)=O)=O)C)(=S)C2=CC=CC=C2

Synonyms:

• 1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid
• 1-N′,3-N′-Bis(benzenecarbonothioyl)-1-N′,3-N′-dimethylpropanedihydrazide
• Gsk 842879A
• N'~1~,N'~3~-dimethyl-N'~1~,N'~3~-bis(phenylcarbothioyl)propanedihydrazide
• NSC 174939
• Propanedioic acid, 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide]
• Propanedioic acid, bis[2-methyl-2-(phenylthioxomethyl)hydrazide]
• Sta 4783
• Elesclomol

Elesclomol

CAS: 488832-69-5

Formula: C₁₉H₂₀N₄O₂S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 400.5177

Ref: IN-DA00DA9M

N'1,N'3-Dimethyl-N'1,N'3-Di(Phenylcarbonothioyl)Malonohydrazide

CAS: 488832-69-5

N'1,N'3-Dimethyl-N'1,N'3-Di(Phenylcarbonothioyl)Malonohydrazide

Purity: 98%

Molecular weight: 400.52g/mol

Ref: 54-OR1026162

Elesclomol

CAS: 488832-69-5

Elesclomol

Purity: ≥95%

Molecular weight: 400.52g/mol

Ref: 54-BUP13252

Elesclomol

CAS: 488832-69-5

Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier.

Formula: C₁₉H₂₀N₄O₂S₂

Purity: 97.17% - 99.51%

Color and Shape: Solid

Molecular weight: 400.52

Ref: TM-T6170

Elesclomol

CAS: 488832-69-5

Elesclomol is an investigational anticancer agent, which is a small-molecule compound. It functions by targeting the cellular oxidative stress pathway; specifically, it enhances the production of reactive oxygen species (ROS) within cancer cells. By elevating ROS levels beyond the threshold tolerable by cancer cells, Elesclomol induces apoptosis through the disruption of mitochondrial function, making it selective for environments with heightened oxidative stress.

Formula: C₁₉H₂₀N₄O₂S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 400.52 g/mol

Ref: 3D-FE157996

ELESCLOMOL

CAS: 488832-69-5

Purity: 98%

Molecular weight: 400.519989

Ref: 10-F808784