CAS 489-32-7
:Icariin
Description:
Icariin is a flavonoid glycoside primarily derived from the Epimedium genus, commonly known as Horny Goat Weed. It is recognized for its potential pharmacological properties, including antioxidant, anti-inflammatory, and neuroprotective effects. Icariin exhibits a complex structure characterized by a flavone backbone with a glycosidic moiety, which contributes to its biological activity. The substance is often studied for its potential benefits in enhancing sexual health and improving bone density, making it of interest in traditional medicine and modern therapeutic research. Icariin is typically found in various forms, including powders and extracts, and is often used in dietary supplements. Its solubility in organic solvents and limited solubility in water can influence its bioavailability and efficacy. As with many natural compounds, the specific effects and mechanisms of action of icariin are still under investigation, and its safety profile is an important consideration for its use in health products.
Formula:C33H40O15
InChI:InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
InChI key:InChIKey=TZJALUIVHRYQQB-XLRXWWTNSA-N
SMILES:C(C=C(C)C)C1=C2C(C(=O)C(O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)=C(O2)C4=CC=C(OC)C=C4)=C(O)C=C1O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O
Synonyms:- 2,6-anhydro-1-deoxy-7-O-[7-(beta-D-glucopyranosyloxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl]-L-glycero-L-manno-heptitol
- 3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
- 3-[(6-Deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)oxy]-7-(β-<smallcap>D</span>-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
- 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
- 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)oxy]-7-(β-<smallcap>D</span>-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
- 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)oxy]-7-(β-<smallcap>D</span>-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-
- Epimedium
- Epimedium PE
- Epimedium extract
- Horny goat weed extract
- Icariine
- Icariln
- Ieariline
- Epimediun P.E.
- 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-
- 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
- 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
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Found 16 products.
Icariin
CAS:Formula:C33H40O15Purity:>96.0%(HPLC)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:676.67Icariin, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci
Formula:C33H40O15Purity:98%Color and Shape:Pale yellow, PowderMolecular weight:676.67Icariin
CAS:Icariin analytical standard provided with w/w absolute assay, to be used for quantitative titration.Formula:C33H40O15Purity:(HPLC) ≥99%Color and Shape:PowderMolecular weight:676.67Icariin
CAS:Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Icariin has been reported to have anti-hypoxic, phytoestrogenic, anti-osteoporotic, anti-inflammatory, neuroprotective, and anti-depressant-like activities. Icariin is effective in the attenuation of AHR and chronic airway inflammatory changes in OVA-induced murine asthma model, and this effect is associated with regulation of Th17/Treg responses. Icariin inhibited NF-κB signaling activation and the NLRP3-inflammasome/caspase-1/IL-1β axis.Formula:C33H40O15Purity:95%~99%Molecular weight:676.668Icariin
CAS:Icariin (Ieariline) is a flavonol glycoside that inhibits PDE5 and PDE4 activity and is a PPARα activator. Cost-effective and quality-assured.Formula:C33H40O15Purity:97.82% - 98.3%Color and Shape:SolidMolecular weight:676.66Icariin
CAS:Formula:C33H40O15Purity:≥ 96.0%Color and Shape:Pale yellow to yellow powderMolecular weight:676.66Icariin
CAS:Natural glycosideFormula:C33H40O15Purity:≥ 90.0 % (HPLC)Color and Shape:PowderMolecular weight:676.67Icariin
CAS:Controlled ProductStability Light Sensitive
Applications Icariin inhibits the ROS-dependent JNK and p38 pathways.
References Zhou, H., et al.: Exp. Ther. Med., 7, 1116 (2014)Formula:C33H40O15Color and Shape:NeatMolecular weight:676.66Icariin
CAS:Icariin is a bioactive flavonoid compound, which is primarily derived from plants in the genus Epimedium, commonly known as Horny Goat Weed. This compound is a prenylated flavonol glycoside that is found in varying concentrations depending on the specific species of Epimedium used. Icariin exerts its effects through multiple biochemical pathways, most notably by inhibiting phosphodiesterase type 5 (PDE5), which leads to an increase in nitric oxide levels and the subsequent vasodilation of blood vessels.
Formula:C33H40O15Purity:Min. 95%Color and Shape:Slightly Yellow PowderMolecular weight:676.66 g/mol
