CAS 490-17-5

α-Truxilline

Description:

α-Truxilline, with the CAS number 490-17-5, is an alkaloid derived from the plant species of the genus *Piper*. It is characterized by its complex bicyclic structure, which includes a fused indole and a piperidine ring. This compound is typically found in trace amounts in certain plant extracts and has garnered interest for its potential biological activities. α-Truxilline exhibits a range of pharmacological properties, including anti-inflammatory and analgesic effects, making it a subject of research in medicinal chemistry. Its solubility characteristics can vary, often being more soluble in organic solvents than in water. The compound's stability is influenced by environmental factors such as light and temperature, which can affect its reactivity and shelf life. As with many alkaloids, α-Truxilline's effects on biological systems are mediated through interactions with various receptors, highlighting its potential utility in drug development. However, further studies are necessary to fully elucidate its mechanisms of action and therapeutic potential.

Formula: C₃₈H₄₆N₂O₈

InChI: InChI=1S/C38H46N2O8/c1-39-23-15-17-25(39)31(35(41)45-3)27(19-23)47-37(43)33-29(21-11-7-5-8-12-21)34(30(33)22-13-9-6-10-14-22)38(44)48-28-20-24-16-18-26(40(24)2)32(28)36(42)46-4/h5-14,23-34H,15-20H2,1-4H3/t23-,24-,25+,26+,27-,28-,29-,30-,31+,32+,33-,34-/m0/s1

InChI key: InChIKey=BUOSLGZEBFSUDD-XFKBZBJISA-N

SMILES: C(O[C@@H]1[C@H](C(OC)=O)[C@@]2(N(C)[C@](C1)(CC2)[H])[H])(=O)[C@@H]3[C@@H]([C@@H](C(O[C@@H]4[C@H](C(OC)=O)[C@@]5(N(C)[C@](C4)(CC5)[H])[H])=O)[C@H]3C6=CC=CC=C6)C7=CC=CC=C7

Synonyms:

• Cocamine
• 1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1,3-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1α,2α,3β,4β)-
• 1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, bis[2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, stereoisomer
• 1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1α,2α,3β,4β)-
• α-Truxilline

α-Truxilline

Controlled Product

CAS: 490-17-5

Applications α-Truxillin is an alkaloid found in coca leaves. It is an impurity of illicit Cocaine (C633500), which inhibits the dopamine, norepinephrine, and serotonin transporters.
References Moore, J., et al.: J. Chromatogr. A, 659, 163 (1994); Lurie, I., et al.: Electrophoresis, 19, 51 (1998); Blakely, R.D., et al.: Curr. Opin. Neurobiol., 10, 328 (2000); Cowell, R. M., et al.: Eur. J. Pharmacol., 389, 59 (2000); Fleckenstein, A.E., Eur. J. Pharmacol., 406, 1 (2000); Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003);

Formula: C₃₈H₄₆N₂O₈

Color and Shape: Off-White To Light Yellow

Molecular weight: 658.78

Ref: TR-T895550

α-truxillin

Controlled Product

CAS: 490-17-5

Alpha-truxillin is a potent inhibitor of chitin kinase, which is involved in the growth and proliferation of cancer cells. It has been found to have anticancer properties and can induce apoptosis in tumor cells. Alpha-truxillin is an analog of heparin, a naturally occurring anticoagulant. It has been shown to inhibit the growth of human cancer cells in vitro and in vivo. This compound also inhibits the activity of chitinase, an enzyme that breaks down chitin, a major component of fungal cell walls. Alpha-truxillin has been isolated from Chinese urine and may have potential as a therapeutic agent for cancer treatment.

Formula: C₃₈H₄₆N₂O₈

Purity: Min. 95%

Molecular weight: 658.8 g/mol

Ref: 3D-AAA49017