CAS 491-36-1

4(1H)-Quinazolinone

Description:

4(1H)-Quinazolinone, with the CAS number 491-36-1, is a heterocyclic organic compound characterized by a fused bicyclic structure containing a quinazoline ring system. This compound features a carbonyl group at the 4-position of the quinazoline ring, contributing to its reactivity and potential biological activity. It is typically a white to off-white crystalline solid, exhibiting moderate solubility in polar solvents such as water and alcohols. 4(1H)-Quinazolinone is known for its diverse pharmacological properties, including antimicrobial, anti-inflammatory, and anticancer activities, making it a subject of interest in medicinal chemistry. The compound can participate in various chemical reactions, such as nucleophilic substitutions and cyclizations, due to the presence of the nitrogen atoms in its structure. Its derivatives are often synthesized to enhance biological activity or to explore new therapeutic applications. Overall, 4(1H)-Quinazolinone serves as a valuable scaffold in drug discovery and development.

Formula: C₈H₆N₂O

InChI: InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)

InChI key: InChIKey=QMNUDYFKZYBWQX-UHFFFAOYSA-N

SMILES: O=C1C=2C(NC=N1)=CC=CC2

Synonyms:

• 1H-Quinazolin-4-one
• 3,4-Dihydroquinazolin-4-One
• 4(1H)-Quinazolinone
• 4(3H)-Quinazolinone
• 4(3H)-Quinazolone
• 4-Hydroxy Quinazoline
• 4-Oxo-3,4-dihydroquinazoline
• 4-Oxoquinazoline
• 4-Quinazolinol
• 4-Quinazolinone
• 4-Quinazolone
• C 201-0583
• Hydroxyquinazoline
• NSC 5863

4-Hydroxyquinazoline

CAS: 491-36-1

Formula: C₈H₆N₂O

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 146.15

Ref: 3B-H0803

4-Hydroxyquinazoline, 98%

CAS: 491-36-1

4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription f

Formula: C₈H₆N₂O

Purity: 98%

Color and Shape: White to cream, Crystals or crystalline powder or needles or flakes or chunks

Molecular weight: 146.15

Ref: 02-A17129

Quinazolin-4(3H)-one

CAS: 491-36-1

Formula: C₈H₆N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 146.1460

Ref: IN-DA0010IX

4-Hydroxyquinazoline

CAS: 491-36-1

4-Hydroxyquinazoline

Purity: 98%

Molecular weight: 146.15g/mol

Ref: 54-OR28898

4(3H)-Quinazolinone

CAS: 491-36-1

4(3H)-Quinazolinone

Purity: ≥98%

Molecular weight: 146.15g/mol

Ref: 54-BUP18583

4-Hydroxyquinazoline

CAS: 491-36-1

Formula: C₈H₆N₂O

Molecular weight: 146.15

Ref: 7W-GL4576

4-Quinazolinone

CAS: 491-36-1

Formula: C₈H₆N₂O

Molecular weight: 146.15

Ref: 4Z-Q-011001

4(3H)-Quinazolinone

CAS: 491-36-1

4(3H)-Quinazolinone (4-Hydroxyquinazoline) is a chemically synthesized masonry block, a biologically active nitrogen heterocyclic compound.

Formula: C₈H₆N₂O

Purity: 99.23%

Color and Shape: White Solid

Molecular weight: 146.15

Ref: TM-TMO2713

4-Hydroxyquinazoline

CAS: 491-36-1

Formula: C₈H₆N₂O

Purity: 98%

Color and Shape: Off-white powder

Molecular weight: 146.149

Ref: 10-F013606

4-Hydroxyquinazoline

Controlled Product

CAS: 491-36-1

Applications 4-Hydroxyquinazoline shows anti-microbial and anti-carcinogenic activity as seen in studies due to the quinazoline moiety.
References Kavitha, H.P. et al.: J. Pharm. Res., 4, 4694 (2011); He, J. et al.: Eur. J. Med. Chem., 54, 925 (2012);

Formula: C₈H₆N₂O

Color and Shape: Neat

Molecular weight: 146.15

Ref: TR-H941415

4-Hydroxyquinazoline

CAS: 491-36-1

4-Hydroxyquinazoline is a molecule that has been synthesized by an asymmetric synthesis. It has been shown to protect against oxidative injury in hl-60 cells and heart tissue, which may be due to the inhibition of mitochondrial ATP levels. 4-Hydroxyquinazoline has also been shown to suppress necrotic cell death, most likely through its ability to inhibit the generation of reactive oxygen species (ROS). This compound binds to the hydroxyl group on the cardiac myofilament, inhibiting binding of ATPase and leading to lack of energy production. 4-Hydroxyquinazoline also inhibits the activity of multi-walled carbon nanotubes, which are responsible for ROS production.

Formula: C₈H₆N₂O

Purity: Min 98%

Color and Shape: Powder

Molecular weight: 146.15 g/mol

Ref: 3D-FH32364

4-Hydroxyquinazoline

CAS: 491-36-1

Formula: C₈H₆N₂O

Color and Shape: Neat

Molecular weight: 146.15

Ref: 04-C14249000