CAS 4910-46-7

Spaglumic acid

Description:

Spaglumic acid, with the CAS number 4910-46-7, is a synthetic amino acid derivative that is primarily recognized for its role as a neuroprotective agent. It is structurally related to glutamic acid, which is a key neurotransmitter in the central nervous system. Spaglumic acid exhibits properties that may help in modulating excitatory neurotransmission, potentially offering therapeutic benefits in conditions associated with neurodegeneration or excitotoxicity. The compound is characterized by its ability to cross the blood-brain barrier, making it relevant in neurological research and potential treatments. Additionally, it has been studied for its effects on metabolic processes and its role in cellular signaling pathways. As with many amino acids, spaglumic acid is soluble in water, which facilitates its use in various biochemical applications. However, detailed pharmacokinetic and pharmacodynamic profiles are essential for understanding its full therapeutic potential and safety profile in clinical settings.

Formula: C₁₁H₁₆N₂O₈

InChI: InChI=1/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/p-3/t6-,7-/m0/s1

InChI key: InChIKey=GUCKKCMJTSNWCU-BQBZGAKWSA-N

SMILES: [C@@H](CC(N[C@@H](CCC(O)=O)C(O)=O)=O)(NC(C)=O)C(O)=O

Synonyms:

• (2S)-2-{[(2S)-2-(acetylamino)-3-carboxylatopropanoyl]amino}pentanedioate
• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-(N-acetyl-<smallcap>L</span>-β-aspartyl)-
• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-acetyl-<smallcap>L</span>-β-aspartyl-
• Ac-Asp(Glu-Oh)-Oh
• Glutamic acid, N-(N-acetyl-<span class="text-smallcaps">L</smallcap>-β-aspartyl)-, <smallcap>L</span>-
• Glutamic acid, N-(N-acetyl-<span class="text-smallcaps">L</span>-β-aspartyl)-
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-β-aspartyl-<smallcap>L</span>-glutamic acid
• N-acetyl-L-beta-aspartyl-L-glutamic acid
• Spaglumic Acid
• β-NAAG
• β-Spaglumic acid
• L-Glutamic acid, N-acetyl-L-β-aspartyl-
• Glutamic acid, N-(N-acetyl-L-β-aspartyl)-, L-
• N-Acetyl-L-β-aspartyl-L-glutamic acid
• L-Glutamic acid, N-(N-acetyl-L-β-aspartyl)-
• Glutamic acid, N-(N-acetyl-L-β-aspartyl)-
• N-ACETYL-BETA-ASP-GLU
• AC-BETA-ASP-GLU-OH
• Ac-b-Asp-Glu-OH, b-NAAG, b-SpagluMic acid
• N-ACETYL-L-ASPARTYL-L-GLUTAMIC ACID NAAG , SPAGLUMIC ACID
• AC-ASP(GLU-OH)-OH USP/EP/BP
• Ac-D(E)-OH
• N-(N-Acetyl-L-β-aspartyl)-L-glutamic acid
• Ac-β-Asp-Glu-OH
• Spaglumic
• N-Acetyl-β-Asp-Glu (β-NAAG)
• n-acetyl-b-asp-glu
• N-acetylaspartylglutamate (NAAG)
• Ac-L-βAsp-L-Glu-OH

Ac-Asp(Glu-OH)-OH

CAS: 4910-46-7

A non-hydrolyzable NAAG isomer which acts as selective metabotropic glutamate receptor-3 (mGluR3) antagonist and NAAG peptidase inhibitor.

Formula: C₁₁H₁₆N₂O₈

Purity: > 98%

Color and Shape: White Lyophilisate

Molecular weight: 304.26

Ref: 01-4028598

β-Spaglumic acid

CAS: 4910-46-7

Formula: C₁₁H₁₆N₂O₈

Purity: 95%

Molecular weight: 304.2533

Ref: IN-DA003SPB

N-Acetyl-β-Asp-Glu

CAS: 4910-46-7

N-Acetyl-β-Asp-Glu

Purity: ≥98%

Molecular weight: 304.25g/mol

Ref: 54-BUP11713

N-Acetyl-β-Asp-Glu

CAS: 4910-46-7

N-Acetyl-β-Asp-Glu is a peptide neurotransmitter, the third most common neurotransmitter in the mammalian nervous system.

Formula: C₁₁H₁₆N₂O₈

Purity: 99.94%

Color and Shape: Solid

Molecular weight: 304.25

Ref: TM-T2596

Ac-Asp(Glu-OH)-OH

CAS: 4910-46-7

Ac-Asp(Glu-OH)-OH is a low potency, but potentiating compound that binds to the cell cytoplasm. It inhibits the uptake of glutamate into the synaptic cleft by binding to acidic granules. This compound may be neuroprotective and inhibit prostate carcinoma growth. Ac-Asp(Glu-OH)-OH has also been shown to inhibit postsynaptic potentials and decrease glutamate release in cerebellar granule cells.

Formula: C₁₁H₁₆N₂O₈

Purity: Min. 95%

Molecular weight: 304.25 g/mol

Ref: 3D-FA108318