CAS 4919-37-3

4-Hydroxy-3,5-dimethylbenzoic acid

Description:

4-Hydroxy-3,5-dimethylbenzoic acid, also known as 4-hydroxy-3,5-xylidic acid, is an aromatic carboxylic acid characterized by the presence of a hydroxyl group and a carboxylic acid functional group attached to a benzene ring that also features two methyl substituents. This compound typically appears as a white to off-white crystalline solid and is soluble in organic solvents, with limited solubility in water. It exhibits properties typical of phenolic compounds, including potential antioxidant activity due to the hydroxyl group. The presence of the methyl groups contributes to its hydrophobic character, influencing its reactivity and interactions in various chemical environments. 4-Hydroxy-3,5-dimethylbenzoic acid can be synthesized through various organic reactions, including the methylation of benzoic acid derivatives. It is used in research and industrial applications, particularly in the synthesis of pharmaceuticals and agrochemicals, owing to its functional groups that can participate in further chemical transformations. Safety data should be consulted for handling and exposure guidelines, as with any chemical substance.

Formula: C₉H₁₀O₃

InChI: InChI=1S/C9H10O3/c1-5-3-7(9(11)12)4-6(2)8(5)10/h3-4,10H,1-2H3,(H,11,12)

InChI key: InChIKey=OMNHTTWQSSUZHO-UHFFFAOYSA-N

SMILES: C(O)(=O)C1=CC(C)=C(O)C(C)=C1

Synonyms:

• 2,6-Dimethyl-4-carboxyphenol
• 3,5-Dimethyl-4-hydroxybenzoic acid
• 4-Hydroxy-3,5-Dimethylbenzoate
• Benzoic acid, 4-hydroxy-3,5-dimethyl-
• NSC 68319
• 4-Hydroxy-3,5-dimethylbenzoic acid

4-Hydroxy-3,5-dimethylbenzoic Acid

CAS: 4919-37-3

Formula: C₉H₁₀O₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 166.18

Ref: 3B-H0938

4-Hydroxy-3,5-dimethylbenzoic acid, 98%

CAS: 4919-37-3

4-hydroxy-3,5-dimethylbenzoic acid is widely used as a reagent for potent TTR amyloidogenesis inhibitors. It plays an important role as an intermediate in agrochemicals and dyestuffs. It is also used in the preparation of mexiletine derivatives. This Thermo Scientific Chemicals brand product was ori

Formula: C₉H₉O₃

Purity: 98%

Color and Shape: White to cream to pink or pale brown, Crystals or powder or crystalline powder

Molecular weight: 165.17

Ref: 02-A13051

4-hydroxy-3,5-dimethylbenzoic acid

CAS: 4919-37-3

Formula: C₉H₁₀O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 166.1739

Ref: IN-DA003LHN

4-Hydroxy-3,5-dimethylbenzoic acid

CAS: 4919-37-3

4-Hydroxy-3,5-dimethylbenzoic acid

Purity: 98%

Molecular weight: 166.17g/mol

Ref: 54-OR936362

4-Hydroxy-3,5-dimethylbenzoic acid

CAS: 4919-37-3

4-Hydroxy-3,5-dimethylbenzoic acid (4HDMBA) is an antimicrobial agent that inhibits bacterial cell growth by binding to the GyrA subunit of DNA gyrase. It is a potent inhibitor of the GyrA subunit, with activity against both mutant and wild type strains. 4HDMBA also has anticancer activity in vitro and in vivo studies have shown that it can inhibit the growth of cells from human cancer cell lines. 4HDMBA is synthesized by reacting amide with chloroacetyl chloride. The carboxylate group on 4HDMBA can be transformed into a hydroxyl group by reaction with sodium hydroxide. The chemical structure of 4HDMBA includes a hydroxy group, a chlorine atom, and a hydroxyl group.

Formula: C₉H₁₀O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 166.17 g/mol

Ref: 3D-FH12873

4-Hydroxy-3,5-dimethylbenzoic acid

CAS: 4919-37-3

Formula: C₉H₁₀O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 166.176

Ref: 10-F233378

4-Hydroxy-3,5-dimethylbenzoic Acid

Controlled Product

CAS: 4919-37-3

Applications 4-Hydroxy-3,5-dimethylbenzoic Acid is used in the synthesis of Mexiletine (M340800) derivatives as orally bioavailable inhibitors. Also, used as a chemical reagent in the preparation of potent transthyretin (TTR) amyloidogenesis inhibitors affecting thyroid hormone.
References Frederickson, M. et al.: J. Med. Chem., 51, 183 (2008); Johnson, S. et al.: J. Med. Chem., 51, 260 (2008);

Formula: C₉H₁₀O₃

Color and Shape: Neat

Molecular weight: 166.17

Ref: TR-H941475