CAS 49606-44-2

2-Oxoquazepam

Description:

2-Oxoquazepam is a chemical compound belonging to the benzodiazepine class, which is known for its psychoactive properties. It is characterized by its structure, which includes a benzene ring fused to a diazepine ring, with a keto group at the second position. This compound is often studied for its potential anxiolytic and sedative effects, similar to other benzodiazepines. 2-Oxoquazepam is typically a white to off-white crystalline solid and is soluble in organic solvents but has limited solubility in water. Its pharmacological profile suggests that it may act on the central nervous system by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA), leading to increased inhibitory activity. Due to its psychoactive nature, it is important to handle this compound with care, considering its potential for dependence and side effects. Research into its therapeutic applications and safety profile continues, contributing to the understanding of benzodiazepine derivatives in clinical settings.

Formula: C₁₇H₁₁ClF₄N₂O

InChI: InChI=1S/C17H11ClF4N2O/c18-10-5-6-14-12(7-10)16(11-3-1-2-4-13(11)19)23-8-15(25)24(14)9-17(20,21)22/h1-7H,8-9H2

InChI key: InChIKey=YFSXBSRGIRSXAD-UHFFFAOYSA-N

SMILES: C(C(F)(F)F)N1C=2C(C(=NCC1=O)C3=C(F)C=CC=C3)=CC(Cl)=CC2

Synonyms:

• 2-Oxoquazepam
• 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
• 7-Chloro-1-(2,2,2-trifluoroethyl)-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
• 7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• Oxoquazepam
• Sch 15725
• 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one
• 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one

Quazepam Related Compound A (7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-one)

CAS: 49606-44-2

Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₁₇H₁₁ClF₄N₂O

Color and Shape: Off-White Cream Powder

Molecular weight: 370.0496

Ref: 45-1592227

7-Chloro-1-(2,2,2-trifluoroethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one

Controlled Product

CAS: 49606-44-2

Color and Shape: Neat

Ref: 86-MM3410.01

7-Chloro-5-(2-fluorophenyl)-1,3-Dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one

Controlled Product

CAS: 49606-44-2

Quazepam is a benzodiazepine drug that binds to the benzodiazepine binding site of the GABAA receptor. It has clinical properties as an anxiolytic and anticonvulsant. Quazepam has been determined to have a high affinity for the benzodiazepine binding site in human liver, plasma, and brain tissue. The kinetic data for quazepam show that it is metabolized by oxidation and hydrolysis, which result in two metabolites: N-desmethyldiazepam and oxazepam. Quazepam is also shown to induce sleep, even at doses of 25 mg or less per day. The clinical properties of quazepam are similar to those of other benzodiazepines with a short half-life such as triazolam. However, it does not have significant drug interactions with other drugs like triazolam does.

Formula: C₁₇H₁₁ClF₄N₂O

Purity: Min. 98 Area-%

Color and Shape: Solid

Molecular weight: 370.73 g/mol

Ref: 3D-FC101766

2-Desthio-2-oxo Selapam

Controlled Product

CAS: 49606-44-2

Applications 2-Desthio-2-oxo Selapam is a compound related to Selapam (S253000), a benzodiazepine derivative drug and is known to bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activty, motor coordination and memory.
References Rasmussen, H.B., et al.: Pharma. Genom., 22, 471 (2012); Noorizadeh, H., et al.: Medn. Chem. Rsch., 21, 4357 (2012); Mauri, M.C., et al.: Int. J. Clin. Pharmacol. Res., 13, 173 (1993);

Formula: C₁₇H₁₁ClF₄N₂O

Color and Shape: Off-White To Light Brown

Molecular weight: 370.7287

Ref: TR-D297475