CAS 49625-89-0

β-Naltrexol

Description:

β-Naltrexol is an opioid antagonist that is primarily used in the research and treatment of opioid dependence and addiction. It is a metabolite of naltrexone, which is commonly used to manage opioid and alcohol dependence. β-Naltrexol functions by blocking the effects of opioids at the μ-opioid receptor, thereby reducing the euphoric effects associated with opioid use. This compound is characterized by its high affinity for opioid receptors, particularly the μ subtype, and exhibits a longer half-life compared to its parent compound, naltrexone. β-Naltrexol is typically administered orally and has been studied for its potential in treating various conditions related to opioid misuse. Its chemical structure includes a cyclopropyl group and a hydroxyl group, contributing to its pharmacological properties. As with other opioid antagonists, β-Naltrexol may have side effects, including nausea, headache, and potential withdrawal symptoms in individuals dependent on opioids. Overall, β-Naltrexol represents an important tool in the pharmacological management of opioid-related disorders.

Formula: C₂₀H₂₅NO₄

InChI: InChI=1S/C20H25NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,14-15,18,22-24H,1-2,5-10H2/t14-,15-,18+,19+,20-/m1/s1

InChI key: InChIKey=JLVNEHKORQFVQJ-PYIJOLGTSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3([C@H](O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC6CC6)CC4)[H]

Synonyms:

• (5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxymorphinan-3,6,14-triol
• 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6β-ol
• 6β-Hydroxynaltrexone
• 6β-Naltrexol
• Morphinan-3,6,14-Triol, 17-(Cyclopropylmethyl)-4,5-Epoxy-, (5Alpha,6Beta)-
• Morphinan-3,6,14-triol, 17-(cyclopropylmethyl)-4,5-epoxy-, (5α,6β)-
• b-Naltrexol
• beta-Naltrexol

6-β-Naltrexol, 1mg/ml in Methanol

Controlled Product

CAS: 49625-89-0

Color and Shape: Single Solution

Ref: LP-M-1842-FB-1LM

6-β-Naltrexol

CAS: 49625-89-0

Color and Shape: Neat

Ref: LP-M-1842-FB-10

6β-Naltrexol

Controlled Product

CAS: 49625-89-0

Applications A metabolite of Naltrexone. Narcotic antagonist.
References Portoghese, P., et al,: J. Med. Chem., 37, 579 (1994), Ohkawa, S., et al.: J. Med. Chem., 41, 4177 (1998).

Formula: C₂₀H₂₅NO₄

Color and Shape: Off-White To Light Yellow

Molecular weight: 343.42

Ref: TR-N285700

6β-Naltrexol-d4

Controlled Product

CAS: 49625-89-0

Applications An isotope Labelled metabolite of Naltrexone. Narcotic antagonist.
References Portoghese, P., et al.: J. Med. Chem., 37, 579 (1994), Ohkawa, S., et al.: J. Med. Chem., 41, 4177 (1998),

Formula: C₂₀H₂₁D₄NO₄

Color and Shape: Neat

Molecular weight: 347.44

Ref: TR-N285702

6β-Naltrexol

CAS: 49625-89-0

Formula: C₂₀H₂₅NO₄

Molecular weight: 343.4

Ref: ST-EA-CP-N57017

6β-Naltrexol

CAS: 49625-89-0

6β-Naltrexol is a peripherally selective opioid antagonist that reduces constipation from opioids while minimizing central nervous system effects.

Formula: C₂₀H₂₅NO₄

Purity: 99.933%

Color and Shape: Solid

Molecular weight: 343.42

Ref: TM-T85517