CAS 49627-27-2

Sulindac sulfide

Description:

Sulindac sulfide is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic and anti-inflammatory properties. It is a metabolite of sulindac, which is often utilized in the treatment of conditions such as arthritis and other inflammatory disorders. The chemical structure of sulindac sulfide features a sulfinyl group, contributing to its pharmacological activity. It exhibits a relatively low solubility in water, which can influence its bioavailability and absorption in the body. The compound operates by inhibiting cyclooxygenase enzymes, leading to a decrease in the synthesis of prostaglandins, which are mediators of inflammation and pain. Additionally, sulindac sulfide has been studied for its potential chemopreventive effects in certain types of cancer. As with many NSAIDs, it may have side effects, including gastrointestinal issues and cardiovascular risks, necessitating careful consideration in clinical use. Overall, sulindac sulfide represents a significant compound in the realm of anti-inflammatory medications, with ongoing research into its broader therapeutic applications.

Formula: C₂₀H₁₇FO₂S

InChI: InChI=1/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChI key: InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N

SMILES: C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(SC)C=C3

Synonyms:

• (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid
• (Z)-Sulindac sulfide
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)-
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-
• Sulindac sulfide
• Sulindac sulfide, (Z)-
• cis-Sulindac sulfide
• (Z)-5-Fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-1H-indene-3-acetic acid
• Sulindac EP Impurity C (Sulindac Sulfide)
• SULINDAC SULPHIDE
• Einecs 256-403-9
• (Z)-5-FLUORO-2-METHYL-1-[P-(METHYLTHIO)BENZYLIDENE]INDENE-3-ACETIC ACID
• (Z)-5-FLUORO-2-METHYL-1-(4-METHYLTHIOBENZYLIDENE)-1H-INDEN-3-YLACETIC ACID
• Sulindac Impurity 3（Sulindac EP Impurity C）

Sulindac Related Compound C ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylthio)benzylidene]-1H-inden-3-yl}acetic acid)

CAS: 49627-27-2

Other aromatic organo-sulfur compounds (excluding pesticides)

Formula: C₂₀H₁₇FO₂S

Color and Shape: Yellow Powder

Molecular weight: 340.09333

Ref: 45-1642031

Sulindac EP Impurity C (Sulindac USP Related Compound C, Sulindac Sulfide)

CAS: 49627-27-2

Formula: C₂₀H₁₇FO₂S

Color and Shape: Yellow Solid

Molecular weight: 340.41

Ref: 4Z-S-293

Sulindac sulfide

CAS: 49627-27-2

Sulindac sulfide

Purity: ≥98%

Molecular weight: 340.41g/mol

Ref: 54-BUP11547

Sulindac Sulphane

CAS: 49627-27-2

Color and Shape: Neat

Ref: 86-MM0624.03

Sulindac Sulfide

CAS: 49627-27-2

Stability Hygroscopic
Applications An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.
References Hermann, C., et al.: Oncogene, 17, 1769 (1998), Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999), Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000),

Formula: C₂₀H₁₇FO₂S

Color and Shape: Yellow-Orange

Molecular weight: 340.41

Ref: TR-S699220

Z-Sulindac sulphide

CAS: 49627-27-2

(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid is a potent inhibitor of protein synthesis. It has been shown to inhibit the activity of sulindac sulfide, a cyclase inhibitor and nonsteroidal anti-inflammatory agent, in human polymorphonuclear leukocytes and cancer cells. (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid also inhibits the mitochondrial membrane potential and reduces the growth of cancer cells by inhibiting proteins that are involved in cell proliferation.

Formula: C₂₀H₁₇FO₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 340.41 g/mol

Ref: 3D-FS27970

Sulindac Sulfide-d6 (Major)

Controlled Product

CAS: 49627-27-2

Formula: C₂₀D₆H₁₁FO₂S

Color and Shape: Neat

Molecular weight: 346.448

Ref: TR-S699222

Sulindac sulfide

CAS: 49627-27-2

Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.

Formula: C₂₀H₁₇FO₂S

Purity: 99.35%

Color and Shape: Solid

Molecular weight: 340.41

Ref: TM-T13037

Sulindac EP Impurity C

CAS: 49627-27-2

Formula: C₂₀H₁₇FO₂S

Molecular weight: 340.41

Ref: ST-EA-CP-S108003