CAS 49627-27-2: Sulindac sulfide
Description:Sulindac sulfide is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic and anti-inflammatory properties. It is a metabolite of sulindac, which is often utilized in the treatment of conditions such as arthritis and other inflammatory disorders. The chemical structure of sulindac sulfide features a sulfinyl group, contributing to its pharmacological activity. It exhibits a relatively low solubility in water, which can influence its bioavailability and absorption in the body. The compound operates by inhibiting cyclooxygenase enzymes, leading to a decrease in the synthesis of prostaglandins, which are mediators of inflammation and pain. Additionally, sulindac sulfide has been studied for its potential chemopreventive effects in certain types of cancer. As with many NSAIDs, it may have side effects, including gastrointestinal issues and cardiovascular risks, necessitating careful consideration in clinical use. Overall, sulindac sulfide represents a significant compound in the realm of anti-inflammatory medications, with ongoing research into its broader therapeutic applications.
Formula:C20H17FO2S
InChI:InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChI key:InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N
SMILES:O=C(O)CC=1C=2C=C(F)C=CC2C(=CC3=CC=C(SC)C=C3)C1C
- Synonyms:
- (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid
- (Z)-Sulindac sulfide
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)-
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-
- Sulindac sulfide
- Sulindac sulfide, (Z)-
- cis-Sulindac sulfide
- (Z)-5-Fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-1H-indene-3-acetic acid
