CAS 496791-37-8

4-Isoxazolidinol,2-[[6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxothieno[2,3-d]pyrimidin-5-yl]carbonyl]-, (4S)-

Description:

4-Isoxazolidinol, 2-[[6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxothieno[2,3-d]pyrimidin-5-yl]carbonyl]-, (4S)- is a complex organic compound characterized by its unique structural features, including an isoxazolidinol moiety and a thieno[2,3-d]pyrimidine core. The presence of a pyrazole ring contributes to its potential biological activity, while the stereochemistry indicated by (4S) suggests specific spatial arrangements that may influence its interactions with biological targets. This compound may exhibit properties such as solubility in organic solvents, moderate stability under standard conditions, and potential reactivity due to functional groups like carbonyls and heterocycles. Its molecular structure suggests possible applications in medicinal chemistry, particularly in the development of pharmaceuticals, owing to the diverse functionalities that can interact with biological systems. Further studies would be necessary to elucidate its specific properties, including its pharmacokinetics, mechanism of action, and therapeutic potential.

Formula: C₂₁H₂₇N₅O₅S

AR-C155858

CAS: 496791-37-8

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).

Formula: C₂₁H₂₇N₅O₅S

Purity: 98.96% - 99.42%

Color and Shape: Solid

Molecular weight: 461.53

Ref: TM-T14316

(S)-6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4-hydroxyisoxazolidin-2-yl)carbonyl]-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

CAS: 496791-37-8

Formula: C₂₁H₂₇N₅O₅S

Purity: 95%

Color and Shape: Solid

Molecular weight: 461.5346

Ref: IN-DA00DB4U

AR-C155858

CAS: 496791-37-8

AR-C155858

Purity: ≥98%

Molecular weight: 461.53g/mol

Ref: 54-BUP04734

AR-C155858

CAS: 496791-37-8

AR-C155858

Purity: 99%

Molecular weight: 461.53g/mol

Ref: 54-BISN0018

AR-C155858

Controlled Product

CAS: 496791-37-8

Applications AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
References Ovens, M.J., et al.: Biochem. J., 425, 523 (2010);

Formula: C₂₁H₂₇N₅O₅S

Color and Shape: Neat

Molecular weight: 461.535

Ref: TR-A187720

AR-C155858

CAS: 496791-37-8

AR-C155858 is an ancillary inhibitor that targets the ATP synthase in mitochondria. It is known to inhibit the mitochondrial membrane potential and, as a result, inhibits mitochondrial ATP synthesis. This drug has been shown to inhibit the uptake of glucose and oxygen and decrease the production of reactive oxygen species by tumor cells in vitro. AR-C155858 has also been shown to be potent against hypoxic solid tumours in vivo.

Formula: C₂₁H₂₇N₅O₅S

Purity: Min. 95%

Molecular weight: 461.53 g/mol

Ref: 3D-WUA79137