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CAS 496794-70-8

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GLI1-Mediated transcription inhibitor

Description:
GLI1-Mediated transcription inhibitor, with the CAS number 496794-70-8, is a chemical compound that functions primarily as a small molecule inhibitor targeting the GLI family of transcription factors, particularly GLI1. These transcription factors are crucial in the Hedgehog signaling pathway, which plays a significant role in cell growth, differentiation, and development. Inhibition of GLI1 can be beneficial in therapeutic contexts, particularly in cancers where the Hedgehog pathway is aberrantly activated. The compound is characterized by its ability to disrupt the transcriptional activity of GLI1, thereby potentially reducing tumor proliferation and promoting apoptosis in cancer cells. It is typically studied in the context of cancer research, particularly in tumors associated with Hedgehog signaling dysregulation. The compound's efficacy, specificity, and safety profile are subjects of ongoing research, making it a candidate for further development in targeted cancer therapies. As with many small molecule inhibitors, its pharmacokinetics, bioavailability, and potential side effects are critical factors for consideration in clinical applications.
Formula:C24H23ClN4O3
Synonyms:
  • N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide
  • BenzaMide, N-[4-chloro-3-[6-(diMethylaMino)-1H-benziMidazol-2-yl]phenyl]-3,5-diMethoxy-
  • N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
  • N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3
  • 104683
  • GLI1-Mediated transcription inhibitor
  • N-(4-chloro-3-(5-(diMethylaMino)-1H-benzo[d]iMidazol-2-yl)phenyl)-3,5-diMethoxybenzaMide
  • HhAntag
  • N-[4-Chloro-3-[5-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
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