CAS 496868-77-0

Adarotene

Description:

Adarotene, with the CAS number 496868-77-0, is a synthetic retinoid, which is a class of compounds related to vitamin A. It is primarily characterized by its ability to modulate gene expression through interaction with retinoic acid receptors (RARs), influencing cellular differentiation and proliferation. Adarotene has been investigated for its potential therapeutic applications, particularly in the treatment of certain types of cancer, including cutaneous T-cell lymphoma. Its mechanism of action involves promoting apoptosis in malignant cells and inhibiting tumor growth. The compound is typically administered in a topical or oral form, depending on the specific treatment protocol. Adarotene is known for its side effects, which may include skin irritation, dryness, and potential teratogenic effects, necessitating careful monitoring during use. As a retinoid, it also shares some characteristics with other compounds in its class, such as the ability to affect skin cell turnover and improve skin texture. Overall, Adarotene represents a significant advancement in targeted cancer therapies, particularly in dermatological applications.

Formula: C₂₅H₂₆O₃

InChI: InChI=1S/C25H26O3/c26-23-7-6-21(20-4-1-16(2-5-20)3-8-24(27)28)12-22(23)25-13-17-9-18(14-25)11-19(10-17)15-25/h1-8,12,17-19,26H,9-11,13-15H2,(H,27,28)/b8-3+

InChI key: InChIKey=QAWBIEIZDDIEMW-FPYGCLRLSA-N

SMILES: OC=1C(C23CC4CC(C2)CC(C3)C4)=CC(=CC1)C5=CC=C(/C=C/C(O)=O)C=C5

Synonyms:

• (2E)-3-(4'-Hydroxy-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl)-2-propenoic acid
• (2E)-3-(4′-Hydroxy-3′-tricyclo[3.3.1.1^3,7]dec-1-yl[1,1′-biphenyl]-4-yl)-2-propenoic acid
• (E)-3-[4-[3-(1-Adamantyl)-4-hydroxyphenyl]phenyl]prop-2-enoic acid
• 2-Propenoic acid, 3-(4′-hydroxy-3′-tricyclo[3.3.1.1^3,7]dec-1-yl[1,1′-biphenyl]-4-yl)-, (2E)-
• 3-(4'-Hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
• Adarotene
• St 1926
• 2-Propenoic acid, 3-(4′-hydroxy-3′-tricyclo[3.3.1.13,7]dec-1-yl[1,1′-biphenyl]-4-yl)-, (2E)-

Adarotene

CAS: 496868-77-0

Adarotene (ST1926) induces apoptosis, causes DNA damage, and has strong antiproliferative effects on human tumors.

Formula: C₂₅H₂₆O₃

Purity: 99.26%

Color and Shape: Solid

Molecular weight: 374.47

Ref: TM-T14125

(2E)-3-(4'-Hydroxy-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl)-2-propenoic acid

CAS: 496868-77-0

Formula: C₂₅H₂₆O₃

Purity: %

Color and Shape: Solid

Molecular weight: 374.4721

Ref: IN-DA00DB4N

Adarotene

CAS: 496868-77-0

Adarotene

Purity: ≥98%

Molecular weight: 374.47g/mol

Ref: 54-BUP12676

Adarotene

Controlled Product

CAS: 496868-77-0

Formula: C₂₅H₂₆O₃

Color and Shape: Neat

Molecular weight: 374.472

Ref: TR-A217325