CAS 49763-96-4

Stiripentol

Description:

Stiripentol is an anticonvulsant medication primarily used in the treatment of epilepsy, particularly in patients with Dravet syndrome, a severe form of epilepsy. It is classified as a benzodioxole derivative and functions by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits neuronal excitability. Stiripentol is known for its ability to increase the effectiveness of other antiepileptic drugs, particularly clobazam, and is often used in combination therapy. The substance has a relatively low solubility in water, which can affect its bioavailability. Its pharmacokinetics involve hepatic metabolism, and it is primarily excreted through the urine. Common side effects may include sedation, loss of appetite, and gastrointestinal disturbances. Due to its specific therapeutic applications and interactions with other medications, stiripentol is typically prescribed under careful medical supervision. As with any medication, monitoring for efficacy and adverse effects is essential to ensure optimal treatment outcomes for patients with epilepsy.

Formula: C₁₄H₁₈O₃

InChI: InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3

InChI key: InChIKey=IBLNKMRFIPWSOY-UHFFFAOYSA-N

SMILES: C(=CC(C(C)(C)C)O)C=1C=C2C(=CC1)OCO2

Synonyms:

• (1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
• 1-(1,3-Benzodioxol-5-Yl)-4,4-Dimethylpent-1-En-3-Ol
• 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol
• 1-Penten-3-ol, 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-
• 256-480-9
• 4,4-Dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-ol
• Bcx 2600
• Diacomit
• Stiripentol

Stiripentol

CAS: 49763-96-4

Formula: C₁₄H₁₈O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 234.2909

Ref: IN-DA00D90N

Stiripentol

CAS: 49763-96-4

Stiripentol

Purity: ≥98%

Molecular weight: 234.29g/mol

Ref: 54-BUP15392

1-(Benzo[d][1,3]Dioxol-5-Yl)-4,4-Dimethylpent-1-En-3-Ol

CAS: 49763-96-4

1-(Benzo[d][1,3]Dioxol-5-Yl)-4,4-Dimethylpent-1-En-3-Ol

Purity: 99%

Molecular weight: 234.29g/mol

Ref: 54-OR1008962

Stiripentol

CAS: 49763-96-4

Formula: C₁₄H₁₈O₃

Purity: ≥ 98.0%

Color and Shape: White to off-white powder or solid

Molecular weight: 234.29

Ref: 7W-GP3535

Stiripentol

CAS: 49763-96-4

Formula: C₁₄H₁₈O₃

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 234.30

Ref: 3B-S0905

Stiripentol Impurity 12 (E/Z Mixture)

CAS: 49763-96-4

Formula: C₁₄H₁₈O₃

Molecular weight: 234.30

Ref: 4Z-S-058030

Stiripentol

CAS: 49763-96-4

Stiripentol (BCX2600) (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated by CYP3A4 (noncompetitively) and CYP2C19 (

Formula: C₁₄H₁₈O₃

Purity: 99.87% - >99.99%

Color and Shape: White Solid

Molecular weight: 234.29

Ref: TM-T4498

Stiripentol

Controlled Product

CAS: 49763-96-4

Applications An epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.
References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),

Formula: C₁₄H₁₈O₃

Color and Shape: Light Yellow Solid

Molecular weight: 234.29

Ref: TR-S686825

4,4-Dimethyl-1-[(3,4-methylenedioxy)phenyl]-1-penten-3-ol

CAS: 49763-96-4

4,4-Dimethyl-1-[(3,4-methylenedioxy)phenyl]-1-penten-3-ol is a drug that has been used in the treatment of Dravet syndrome. This drug is also known as 3,4-methylenedioxyphenylacetone. It is a competitive inhibitor of the enzyme citrate synthase and inhibits the conversion of acetate to citrate. The effect of 4,4-dimethyl-1-[(3,4-methylenedioxy)phenyl]-1-penten-3-ol on sodium citrate concentrations is concentration dependent and results in an increase in plasma sodium concentrations with prolonged administration. Other drugs that are metabolized by the cytochrome P450 system may interact with 4,4-dimethyl-1-[(3,4 methylenedioxy)phenyl]-1 penten 3 ol and lead to increased levels of these drugs in the blood.

Formula: C₁₄H₁₈O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 234.29 g/mol

Ref: 3D-FS27881

Stiripentol

CAS: 49763-96-4

Formula: C₁₄H₁₈O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 234.295

Ref: 10-F505617

Stiripentol-13C3

Controlled Product

CAS: 49763-96-4

Formula: C₃C₁₁H₁₈O₃

Color and Shape: Neat

Molecular weight: 237.269

Ref: TR-S686822