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CAS 497833-27-9

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Givinostat

Description:
Givinostat, also known by its chemical name, is a small molecule inhibitor primarily recognized for its role as a histone deacetylase (HDAC) inhibitor. It is classified under the category of epigenetic modulators, which means it influences gene expression by altering chromatin structure. Givinostat has been studied for its potential therapeutic applications in various conditions, including cancer and inflammatory diseases, due to its ability to induce cell cycle arrest and apoptosis in cancer cells. The compound exhibits a moderate to high solubility in organic solvents and is typically administered in a pharmaceutical formulation. Its mechanism of action involves the inhibition of HDAC enzymes, leading to an increase in acetylated histones and subsequent modulation of gene expression. Givinostat has undergone clinical trials, demonstrating promise in treating specific hematological malignancies and solid tumors. However, like many investigational drugs, its safety and efficacy profiles are continually evaluated in ongoing research.
Formula:C24H27N3O4
InChI:InChI=1S/C24H27N3O4/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28)
InChI key:InChIKey=YALNUENQHAQXEA-UHFFFAOYSA-N
SMILES:C(N(CC)CC)C1=CC2=C(C=C(COC(NC3=CC=C(C(NO)=O)C=C3)=O)C=C2)C=C1
Synonyms:
  • [6-[(Diethylamino)methyl]naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
  • (6-((Diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate
  • Carbamic acid, N-[4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester
  • Givinostat
  • Carbamic acid, [4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester
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Found 5 products.