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CAS 497871-47-3

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Lurbinectedin

Description:
Lurbinectedin is a synthetic alkaloid derived from the marine organism Ecteinascidia turbinata, commonly known as the sea squirt. It is primarily recognized for its role as an antineoplastic agent, particularly in the treatment of certain types of cancer, including small cell lung cancer. Lurbinectedin functions by binding to DNA, leading to the formation of DNA cross-links, which ultimately disrupts transcription and induces apoptosis in cancer cells. This mechanism of action distinguishes it from traditional chemotherapeutic agents. The compound is characterized by its complex molecular structure, which includes a tetrahydroisoquinoline core and various functional groups that contribute to its biological activity. Lurbinectedin has been studied for its efficacy and safety profile, showing promise in clinical settings, particularly for patients who have progressed after standard therapies. Its pharmacokinetics involve metabolism primarily through the liver, and it is administered via intravenous infusion. As with many chemotherapeutic agents, monitoring for side effects and interactions with other medications is essential during treatment.
Formula:C41H44N4O10S
InChI:InChI=1S/C41H44N4O10S/c1-17-11-20-12-25-39(48)45-26-14-52-40(49)41(38-22(9-10-42-41)23-13-21(50-5)7-8-24(23)43-38)15-56-37(31(45)30(44(25)4)27(20)32(47)33(17)51-6)29-28(26)36-35(53-16-54-36)18(2)34(29)55-19(3)46/h7-8,11,13,25-26,30-31,37,39,42-43,47-48H,9-10,12,14-16H2,1-6H3/t25-,26-,30+,31+,37+,39-,41+/m0/s1
InChI key:InChIKey=YDDMIZRDDREKEP-HWTBNCOESA-N
SMILES:O[C@@H]1N2[C@@]([C@]3(C=4C([C@@]2(COC(=O)[C@@]5(CS3)C6=C(C=7C(N6)=CC=C(OC)C7)CCN5)[H])=C8C(=C(C)C4OC(C)=O)OCO8)[H])([C@]9(C=%10C(C[C@@]1(N9C)[H])=CC(C)=C(OC)C%10O)[H])[H]
Synonyms:
  • Zepsyre
  • Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'-[1H]pyrido[3,4-b]indol]-19-one, 5-(acetyloxy)-2',3',4',6,6a,7,9',13,14,16-decahydro-8,14-dihydroxy-6',9-dimethoxy-4,10,23-trimethyl-, (1'R,6R,6aR,7R,13S,14S,16R)- (9CI)
  • Tryptamicidin
  • Lurbinectedin
  • PM 01183
  • Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′-[1H]pyrido[3,4-b]indol]-19-one, 5-(acetyloxy)-2′,3′,4′,6,6a,7,9′,13,14,16-decahydro-8,14-dihydroxy-6′,9-dimethoxy-4,10,23-trimethyl-, (1′R,6R,6aR,7R,13S,14S,16R)-
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Found 4 products.