CAS 49842-07-1

Tobramycin sulfate

Description:

Tobramycin sulfate is an aminoglycoside antibiotic primarily used to treat infections caused by Gram-negative bacteria, particularly in patients with cystic fibrosis. It is derived from the bacterium *Streptomyces tenebrarius* and is effective against a range of pathogens, including *Pseudomonas aeruginosa*. The substance appears as a white to off-white powder and is soluble in water, which facilitates its use in various formulations, including inhalation solutions and injectable forms. Tobramycin sulfate works by inhibiting bacterial protein synthesis, leading to cell death. Its pharmacokinetics involve renal excretion, necessitating dosage adjustments in patients with impaired kidney function. Common side effects may include nephrotoxicity and ototoxicity, particularly with prolonged use or high doses. Due to its specific action against certain bacteria, tobramycin sulfate is often employed in combination therapies to enhance efficacy and reduce resistance development. As with all antibiotics, it is crucial to use tobramycin sulfate judiciously to minimize the risk of resistance and preserve its effectiveness in treating bacterial infections.

Formula: C₁₈H₃₇N₅O₉H₂O₄S

InChI: InChI=1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1

InChI key: InChIKey=ZEUUPKVZFKBXPW-TWDWGCDDSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)C[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O.S(=O)(=O)(O)O

Synonyms:

• (1S,2S,3R,4S,6R)-4,6-diamino-3-[(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• 1-Epitobramycin sulfate
• 1-Epitobramycinsulfate
• 4,6-Diamino-3-[(3-Amino-3-Deoxyhexopyranosyl)Oxy]-2-Hydroxycyclohexyl 2,6-Diamino-2,3,6-Trideoxyhexopyranoside Sulfate (1:1)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</span>-ribo-hexopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</span>-ribo-hexopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5) (salt)
• D-6-Trideoxy-Alpha-D-Ribohexopyranosyl-(1-4))-2-Deoxysulfate(Salt)
• Distobram
• Gernebcin
• Nebcin
• Nebicina
• O-[3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine sulfate
• Obracin
• Obracine
• Streptamine,O-3-Amino-3-Deoxy-Alpha-D-Glucopyranosyl-(1-6)-O-(2,6-Diamino-2,3,
• Tenemicin
• Tobra
• Tobramycin Sulfate
• Tobramycin Sulfate Salt
• Tobrate
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5)

Tobramycin sulfate

CAS: 49842-07-1

A water-soluble aminoglycoside antibiotic

Formula: (C₁₈H₃₇N₅O₉)₂•5H₂SO₄

Molecular weight: 1425.41

Ref: 02-J62995

Tobramycin (sulfate)

CAS: 49842-07-1

Formula: C₃₆H₈₄N₁₀O₃₈S₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 1425.4214

Ref: IN-DA00I8WD

Tobramycin sulphate

CAS: 49842-07-1

Tobramycin sulphate

Formula: C₁₈H₃₇N₅O₉·H₂O₄S

Color and Shape: White To Off White Powder

Molecular weight: 565.59295g/mol

Ref: 54-BIT0153

Tobramycin sulphate

CAS: 49842-07-1

Formula: (C₁₈H₃₇N₅O₉)₂·5H₂SO₄

Purity: 635 - 740 μg/mg

Color and Shape: White or off-white powder

Molecular weight: 1425.41

Ref: 7W-GA2734

Tobramycin Sulfate

CAS: 49842-07-1

Tobramycin Sulfate (Dartobcin) is an antibacterial nanomedicine, useful in pediatric bacterial pneumonia research.

Formula: C₃₆H₈₄N₁₀O₃₈S₅

Purity: 99.84%

Color and Shape: Solid

Molecular weight: 1425.42

Ref: TM-T1255L

Tobramycin Sulphate Salt

CAS: 32986-56-4, 49842-07-1

Formula: C₁₈H₃₇N₅O₉•x(H₂O₄S)

Color and Shape: Neat

Molecular weight: 565.6

Ref: TR-T524033

Tobramycin sulfate

CAS: 49842-07-1

Inhibitor of protein synthesis; aminoglycoside

Formula: C₁₈H₃₇N₅O₉H₂SO₄

Purity: 634 To 739 Ug/Mg

Color and Shape: White Powder

Molecular weight: 506.75 g/mol

Ref: 3D-AT31916

Tobramycin Hemipentasulfate

CAS: 49842-07-1

Formula: C₁₈H₃₇N₅O₉(H₂SO₄)

Molecular weight: 467.52 : 5/2(98.07)

Ref: ST-EA-CP-T96006