CAS 49843-98-3

EX 527

Description:

EX 527, with the CAS number 49843-98-3, is a selective inhibitor of the enzyme sirtuin 1 (SIRT1), which plays a crucial role in cellular regulation, metabolism, and aging processes. This compound is characterized by its ability to modulate various biological pathways, making it a subject of interest in research related to age-related diseases, metabolic disorders, and cancer. EX 527 is typically presented as a white to off-white solid and is soluble in organic solvents, which facilitates its use in laboratory settings. Its mechanism of action involves the inhibition of SIRT1 activity, leading to alterations in cellular signaling and gene expression. Due to its specificity, EX 527 is valuable for studying the physiological roles of SIRT1 and exploring potential therapeutic applications. However, as with any chemical substance, proper handling and safety precautions are essential, given its biological activity and potential effects on human health.

Formula: C₁₃H₁₃ClN₂O

InChI: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)

InChI key: InChIKey=FUZYTVDVLBBXDL-UHFFFAOYSA-N

SMILES: C(N)(=O)C1C2=C(C=3C(N2)=CC=C(Cl)C3)CCC1

Synonyms:

• 6-Chloro-2,3,4,9-Tetrahydro-1H-Carbazole-1-Carboxamide
• 6-Chloro-2,3,4,9-Tetrahydro-1H-Carbazole-1-Carboxamide, >95%
• 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid amide
• Ex 527
• SIRT1 inhibitor III
• Selisistat
• Sen 0014196
• 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-
• Selisistat (SEN0014196
• CS-1862
• SEN0014196
• (S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
• SELISISTAT;EX 527;EX527;SEN0014196
• EX 527, >=98%
• 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide EX-527 Selisistat
• Selisistat 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide
• 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide &gt
• EX 527; EX527
• EX 527 (SEN0014196)
• 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE USP/EP/BP
• EX 527 (Selisistat)
• EX-527; EX-527; EX-527; SELISISTAT.
• (S)-EX-527

EX 527

CAS: 49843-98-3

A potent and selective inhibitor of the SIRT1 class III histone deacetylase enzyme

Formula: C₁₃H₁₃ClN₂O

Color and Shape: Pale yellow, Powder

Molecular weight: 248.71

Ref: 02-J64753

Selisistat

CAS: 49843-98-3

Selisistat

Purity: ≥98%

Molecular weight: 248.70812g/mol

Ref: 54-BISN0099

Selisistat

CAS: 49843-98-3

Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).

Formula: C₁₃H₁₃ClN₂O

Purity: 98.53% - 99.94%

Color and Shape: Solid

Molecular weight: 248.71

Ref: TM-T6111

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

CAS: 49843-98-3

M04054 - 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Formula: C₁₃H₁₃ClN₂O

Purity: >95%

Color and Shape: Solid

Molecular weight: 248.7100067138672

Ref: 10-M04054

Selisistat

Controlled Product

CAS: 49843-98-3

Formula: C₁₃H₁₃ClN₂O

Color and Shape: Neat

Molecular weight: 248.708

Ref: TR-S253500

EX 527

CAS: 49843-98-3

EX 527 is a peptide substrate that interacts with coenzyme Q10. It has been shown to activate SIRT1, an enzyme that regulates the activity of other proteins and plays an important role in cellular metabolism, leading to improved mitochondrial function, reduced inflammation and oxidative stress, and increased cell survival. When EX 527 was administered to mice, it was found to increase the expression of nicotinic acetylcholine receptor α7 (nAChRα7), which is associated with experimental cancer treatments. In addition, EX 527 has been shown to have therapeutic effects on kidney injury and skin cancer when combined with srt1720 treatment.

Formula: C₁₃H₁₃ON₂Cl

Purity: Min. 95%

Molecular weight: 248.71 g/mol

Ref: 3D-FC34132