CAS 4993-32-2

Estr-5(10)-ene-3β,17β-diol

Description:

Estr-5(10)-ene-3β,17β-diol, also known as estradiol, is a naturally occurring steroid hormone that plays a crucial role in the regulation of the female reproductive system and secondary sexual characteristics. It is a member of the estrogen family and is primarily produced in the ovaries, although it can also be synthesized in smaller amounts in other tissues such as the adrenal glands and fat cells. This compound is characterized by its steroid structure, which includes a phenolic hydroxyl group that contributes to its biological activity. Estradiol is known for its potent estrogenic effects, influencing various physiological processes including the menstrual cycle, bone density, and cardiovascular health. It also has implications in various medical treatments, including hormone replacement therapy and the management of certain cancers. The compound is typically administered in various forms, including oral, transdermal, and injectable preparations, and its pharmacokinetics can vary based on the route of administration. Overall, estradiol is a vital hormone with significant implications for health and disease.

Formula: C₁₈H₂₈O₂

InChI: InChI=1/C18H28O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h12,14-17,19-20H,2-10H2,1H3/t12?,14?,15?,16?,17-,18?/m0/s1

InChI key: InChIKey=IBHQSODTBQCZDA-MACGOEAWSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C4=C(CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@H]2O)[H]

Synonyms:

• Estr-5(10)-ene-3β,17β-diol
• (3β,17β)-Estr-5(10)-ene-3,17-diol
• 3β,17β-Dihydroxy-19-norandrost-5(10)-ene
• Estr-5(10)-ene-3,17-diol, (3β,17β)-

3beta-Dihydroxy-19-norandrost-5(10)-ene

Controlled Product

CAS: 4993-32-2

Applications 3β-Dihydroxy-19-norandrost-5(10)-ene is an intermediate in the synthesis of 3β,17β-Dihydroxy-19-norandrost-5(10)-ene (D453800), which is a metabolite of Androstenedione. A novel 19-norsteroid, from androstenedione and 19-hydroxyandrostenedione by cultured porcine granulosa cells is reported for the first time.
References Haarbo, J., et al.: Clin. Physiol., 11, 331 (1991), Krebs-Smith, S., et al.: Eur. J. Clin. Nutr., 54, 281(2000), Rasmussen, B., et al.: J. Clin. Endocrinol. Metab., 85, 55 (2000),

Formula: C₁₈H₂₈O₂

Color and Shape: Neat

Molecular weight: 276.41

Ref: TR-D499330

3b,17b-Dihydroxy-19-norandrost-5(10)-ene

Controlled Product

CAS: 4993-32-2

Applications A metabolite of Androstenedione. A novel 19-norsteroid, from androstenedione and 19-hydroxyandrostenedione by cultured porcine granulosa cells is reported for the first time.
References Haarbo, J., et al.: Clin. Physiol., 11, 331 (1991), Krebs-Smith, S., et al.: Eur. J. Clin. Nutr., 54, 281(2000), Rasmussen, B., et al.: J. Clin. Endocrinol. Metab., 85, 55 (2000),

Formula: C₁₈H₂₈O₂

Color and Shape: Beige To Light Brown

Molecular weight: 276.41

Ref: TR-D453800

3b,17b-Dihydroxy-19-norandrost-5(10)-ene

Controlled Product

CAS: 4993-32-2

3b,17β-Dihydroxy-19-norandrost-5(10)-ene is a metabolite of oestrone and is converted to 3β-hydroxysteroid dehydrogenase (3βHSD) by an interaction with 17β-hydroxysteroid dehydrogenase (17βHSD). 3b,17β-Dihydroxy-19-norandrost-5(10)-ene has been shown to be involved in the progression of hepatic steatosis. It also has a role in depression and may have antiviral properties. 3b,17β-Dihydroxy-19-norandrost-5(10)-ene is synthesized from progesterone and 17α hydroxylase via 17,20 lyase. The reaction product to this synthesis is progesterone. The conversion of 3b,17β-dihydroxy 19nortestosterone to 3b,17β

Formula: C₁₈H₂₈O₂

Purity: Min. 95%

Molecular weight: 276.41 g/mol

Ref: 3D-FD22074