CAS 50-02-2

Dexamethasone

Description:

Dexamethasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressant properties, commonly used in the treatment of various conditions such as allergies, autoimmune diseases, and certain types of cancer. Its chemical formula is C22H29FO5, and it features a steroid backbone with a fluorine atom and a ketone group, contributing to its potency. Dexamethasone acts by binding to glucocorticoid receptors, influencing gene expression and modulating the immune response. It is typically administered orally, intravenously, or via injection, and its effects can include reduced inflammation and suppression of the immune system. The substance is known for its relatively long half-life compared to other corticosteroids, allowing for less frequent dosing. Side effects may include weight gain, mood changes, and increased risk of infections, particularly with prolonged use. Dexamethasone is also notable for its role in managing severe cases of COVID-19, where it has been shown to improve outcomes in patients requiring oxygen or mechanical ventilation.

Formula: C₂₂H₂₉FO₅

InChI: InChI=1/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15?,16+,17+,19+,20+,21+,22+/m1/s1

InChI key: InChIKey=UREBDLICKHMUKA-CXSFZGCWSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• (8Xi,11Beta,16Alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• 1-Dehydro-16α-methyl-9α-fluorohydrocortisone
• 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 16α-Methyl-9α-fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
• 16α-Methyl-9α-fluoro-Δ1-hydrocortisone
• 16α-Methyl-9α-fluoro-Δ¹-hydrocortisone
• 16α-Methyl-9α-fluoroprednisolone
• 9-Alpha-Fluoro-11-Beta,17-Alpha,21-Trihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
• 9-Alpha-Fluoro-16-Alpha-Methylprednisolone
• 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
• 9α-Fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
• 9α-Fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 9α-Fluoro-16α-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione
• 9α-Fluoro-16α-methylprednisolone
• Adexone
• Aeroseb-Dex
• Aphtasolon
• Aphthasolone
• Azium
• Calonat
• Corsone
• Cortisumman
• Decacort
• Decaderm
• Decadron
• Decalix
• Decasone
• Dekacort
• Dekort
• Delipos
• Deltafluorene
• Dergramin
• Deronil
• Desadrene
• Desameton
• Deseronil
• Dexa-Cortidelt
• Dexa-Mamallet
• Dexa-Scheroson
• Dexa-sine
• Dexacort
• Dexacortal
• Dexacortin
• Dexadeltone
• Dexafarma
• Dexalona
• Dexaltin
• Dexametasona
• Dexameth
• Dexamethason
• Dexamonozon
• Dexapolcort
• Dexapos
• Dexaprol
• Dexaratiopharm
• Dexason
• Dexasone
• Dexaven
• Dexinoral
• Dexium
• Dexmethsone
• Dexone
• Dexonium
• Dextelan
• Dinormon
• Diodex
• Etacortilen
• Fluormethylprednisolone
• Fluormone
• Fluorocort
• Gammacorten
• Gentalipos
• HL-Dex
• Hexadecadrol
• Hexadrol
• Isopto-Dex
• Loverine
• Luxazone
• Maxidex
• Millicorten
• Minidex
• Neofordex
• Oftan
• Oradexon
• Ozurdex
• Posurdex
• Superprednol
• Surodex
• Visumetazone
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16α)-
• MK 125
• DEXAMETHASONE BASE
• DEXAMETHASONE
• (11B,16A)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-PREGNA-1,4-DIENE-3,20-DIONE
• 1,4-PREGNADIENE-3,20-DIONE-9ALPHA-FLUORO-16ALPHA METHYL-11BETA,17ALPHA,21-TRIOL
• 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
• 9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE
• 9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE
• PREDNISOLONE F
• (11BETA,16ALPHA)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
• 1,4-PREGNADIEN-9ALPHA-FLUORO-16ALPHA-METHYL-11BETA, 17ALPHA, 21-TRIOL 3,20-DIONE
• DECACORTIN
• 9ALPHA-FLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYL-1,4-PREGNADIENE 3,20DIONE

Dexamethasone-d3

Controlled Product

CAS: 50-02-2

Applications Dexamethasone-d3 is the labelled form of Dexamethasone (D298800), which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T-cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Formula: C₂₂H₂₆D₃FO₅

Color and Shape: Off-White To Light Beige

Molecular weight: 395.48

Ref: TR-D298803

Dexamethasone Acetate EP Impurity A

CAS: 50-02-2

Formula: C₂₂H₂₉FO₅

Molecular weight: 392.47

Ref: ST-EA-CP-D17031

Dexamethasone

Controlled Product

CAS: 50-02-2

Impurity Dexamethasone Sodium Phosphate EP Impurity A
Applications Dexamethasone (Dexamethasone Sodium Phosphate EP Impurity A) is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);

Formula: C₂₂H₂₉FO₅

Color and Shape: Neat

Molecular weight: 392.46

Ref: TR-D298800

Dexamethasone Sodium phosphate EP Impurity A

CAS: 50-02-2

Formula: C₂₂H₂₉FO₅

Molecular weight: 392.47

Ref: ST-EA-CP-D105001

Betamethasone EP Impurity A

CAS: 50-02-2

Formula: C₂₂H₂₉FO₅

Molecular weight: 392.46

Ref: ST-EA-CP-B25001

Dexamethasone 21-Formate

Controlled Product

CAS: 50-02-2

Applications Dexamethasone 21-Formate is a metabolite of Dexamethasone.
References Minagawa, K., et al.: Steroids, 47, 175 (1986), Murray, G., et al.: Br. J. Clin. Pharmacol., 25, 465 (1988), Ravichandran, K., et al.: Science, 1993, 261, 731 (1993),

Formula: C₂₃H₂₉FO₆

Color and Shape: Neat

Molecular weight: 420.47

Ref: TR-D298910

Dexamethasone base

Controlled Product

CAS: 50-02-2

Dexamethasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is often used to treat various ocular conditions, such as macular edema, retinal detachment, and uveitis. Dexamethasone has been shown to inhibit the migration of leukocytes into the vitreous humor of the eye by binding to glucocorticoid receptors in the cells that line blood vessels in the retina. Dexamethasone also binds to signal peptides on proteins that regulate mitochondrial functions and glucose uptake in cells. This drug can be used for bowel disease treatment, chronic cough management, or as an injection during polymerase chain reactions.

Formula: C₂₂H₂₉FO₅

Purity: (Hplc) 97.0 To 102.0%

Color and Shape: Powder

Molecular weight: 392.46 g/mol

Ref: 3D-FD15640

Dexamethasone Regiomer

Controlled Product

CAS: 50-02-2

Formula: C₂₂H₂₉FO₅

Color and Shape: Neat

Molecular weight: 392.47

Ref: TR-D358235

DEXAMETHASONE

CAS: 50-02-2

Formula: C₂₂H₂₉FO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 392.4611

Ref: IN-DA0034OW

Dexamethasone 1.0 mg/ml in Methanol

CAS: 50-02-2

Color and Shape: Single Solution

Ref: 61-AMP0213.00-01