CAS 50-03-3

Hydrocortisone acetate

Description:

Hydrocortisone acetate, with the CAS number 50-03-3, is a synthetic corticosteroid that is commonly used for its anti-inflammatory and immunosuppressive properties. It is a white to off-white crystalline powder that is practically insoluble in water but soluble in organic solvents such as ethanol and acetone. The substance is often utilized in topical formulations, such as creams and ointments, to treat various skin conditions, including eczema and dermatitis, as well as in injectable forms for systemic effects. Hydrocortisone acetate functions by mimicking the effects of cortisol, a natural hormone produced by the adrenal glands, thereby reducing inflammation and suppressing the immune response. Its pharmacological effects include vasoconstriction, inhibition of leukocyte infiltration, and suppression of cytokine production. While generally well-tolerated, potential side effects may include skin thinning, local irritation, and systemic effects with prolonged use. Proper dosage and administration are crucial to minimize adverse effects and maximize therapeutic benefits.

Formula: C₂₃H₃₂O₆

InChI: InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key: InChIKey=ALEXXDVDDISNDU-JZYPGELDSA-N

SMILES: C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(COC(C)=O)=O)O)[H]

Synonyms:

• (11β)-21-(Acetyloxy)-11,17-dihydroxypregn-4-ene-3,20-dione
• 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate
• 17-Hydroxycorticosterone 21-acetate
• 17α-Hydroxycorticosterone acetate
• 21-Acetate d'hydrocortisone
• 21-Acetato De Hidrocortisona
• 21-Acetoxy-11β,17-dihydroxypregn-4-en-3,20-dione
• 21-Acetoxy-11β,17-dihydroxypregn-4-ene-3,20-dione
• 21-Acetoxy-11β,17α-dihydroxypregn-4-ene-3,20-dione
• 4-Pregnene-11β,17,21-triol-3,20-dione 21-acetate
• Abbocort
• Anusol HC
• Bambicort
• Berlison F
• Biocortar
• CaldeCort
• Chemysone
• Colifoam
• Colofoam
• Cordes
• Cortacream
• Cortaid
• Cortef acetate
• Cortell
• Corticaine
• Cortifoam
• Cortisol acetate
• Cortisol, 21-acetate
• Cortril acetate
• Cortril acetate AS
• Efcolin
• HA
• Hc 45
• Hycortole acetate
• Hydrin 2
• Hydrocal
• Hydrocort acetate
• Hydrocortisat
• Hydrocortison-21-acetat
• Hydrocortisone 21-Acetate
• Hydrocortisone acetate
• Hydrocortistab
• Hydrocortone acetate
• Hydroxycorticosterone acetate
• Isopto-Hydrocortisone
• Lanacort
• Lenirit
• Nsc 741
• Pabracort
• Proctocort
• Sigmacort
• Sintotrat
• Velopural
• Wycort
• 11-beta,17-alpha-dihydroxy-21-acetoxypregesterone
• Acetate-as
• 11beta17alpha-Dihydroxy-21-acetoxypregesterone
• (8xi,9xi,11beta,14xi)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
• Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11β)-
• (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
• 21-acetoxy-4-pregnene-11b,17a-diol-3,20-dione

Prednisolone acetate EP Impurity A

CAS: 50-03-3

Formula: C₂₃H₃₂O₆

Molecular weight: 404.5

Ref: ST-EA-CP-P212001

Hydrocortisone 21-Acetate-D3

Controlled Product

CAS: 50-03-3

Applications Hydrocortisone 21-Acetate-D3 is the labeled compound form of Hydrocortisone 21-Acetate (H714620) which is a glucocorticoid.
References Middleton, B., et al.: J. Biol. Chem., 256, 4827 (1981), Moore, A., et al.: Ann. Clin. Biochem., 22, 435 (1985).

Formula: C₂₃H₂₉D₃O₆

Color and Shape: Neat

Molecular weight: 407.52

Ref: TR-H714622

Hydrocortisone 21-Acetate

Controlled Product

CAS: 50-03-3

Impurity Hydrocortisone EP Impurity C
Applications Hydrocortisone 21-Acetate (Hydrocortisone EP Impurity C) is a glucocorticoid.
References Middleton, B., et al.: J. Biol. Chem., 256, 4827 (1981), Moore, A., et al.: Ann. Clin. Biochem., 22, 435 (1985)

Formula: C₂₃H₃₂O₆

Color and Shape: Neat

Molecular weight: 404.50

Ref: TR-H714620

Hydrocortisone acetate

CAS: 50-03-3

Purity: 95.0%

Color and Shape: Solid, White powder

Molecular weight: 404.50299072265625

Ref: 10-F091494

Hydrocortisone acetate

Controlled Product

CAS: 50-03-3

Hydrocortisone acetate is a synthetic corticosteroid, which is a product derived from the modification of natural adrenal cortex hormones. It functions as an anti-inflammatory and immunosuppressive agent through its interaction with glucocorticoid receptors, leading to the modulation of gene expression involved in immune and inflammatory responses. This interaction inhibits the release of pro-inflammatory mediators and reduces the permeability of capillaries, thereby diminishing inflammation and immune activity.

Formula: C₂₃H₃₂O₆

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 404.5 g/mol

Ref: 3D-FH32127