CAS 50-07-7

Mitomycin C

Description:

Mitomycin C is a potent antitumor antibiotic derived from the bacterium Streptomyces caespitosus. It is classified as an alkylating agent, which means it interferes with DNA synthesis and function, making it effective in treating various cancers, particularly in cases of bladder and gastrointestinal tumors. The compound exhibits a unique mechanism of action by forming cross-links between DNA strands, ultimately leading to cell death. Mitomycin C is typically administered intravenously and is known for its cytotoxic effects, which can result in significant side effects, including myelosuppression, nausea, and potential organ toxicity. Its chemical structure features a quinone moiety, which plays a crucial role in its reactivity and biological activity. Due to its effectiveness, Mitomycin C is often used in combination with other chemotherapeutic agents to enhance therapeutic outcomes. However, careful monitoring is essential during treatment to manage adverse effects and ensure patient safety.

Formula: C₁₅H₁₈N₄O₅

InChI: InChI=1/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7?,13+,15-/m0/s1

InChI key: InChIKey=NWIBSHFKIJFRCO-WUDYKRTCSA-N

SMILES: O(C)[C@]12N(C3=C([C@H]1COC(N)=O)C(=O)C(N)=C(C)C3=O)C[C@]4([C@@]2(N4)[H])[H]

Synonyms:

• (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione
• (6-Amino-8A-Methoxy-5-Methyl-4,7-Dioxo-1,1A,2,4,7,8,8A,8B-Octahydroazireno[2',3':3,4]Pyrrolo[1,2-A]Indol-8-Yl)Methyl Carbamate
• 6-Amino-1,1A,2,8,8A,8B-Hexahydro-8-(Hydroxymethyl)-8A-Methoxy-5-Methylazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione Carbamate (Ester)
• Ametycine
• Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
• Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
• Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1aα,8β,8aα,8bα)]-
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1aα,8β,8aα,8bα)]-
• MMC
• MitoExtra
• Mitocin C
• Mitomicina
• Mitomycin C
• Mitomycin C, Streptomyces caespitosus
• Mitomycine
• Mitonco
• Mitoplus
• Mitozytrex
• Mutamycin
• Mytomycin C
• Mytomycin Kyowa S
• Nsc 26980
• [(1aR,8R,8aS,8bR)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
• [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
• [(8R,8aS,8bR)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
• [1Ar-(1Aalpha,8Beta,8Aalpha,8Balpha)]-6-Amino-8-[[(Aminocarbonyl)Oxy]Methyl]-1,1A,2,8,8A,8B-Hexahydro-8A-Methoxy-5-Methylazirino[2',3':3,4]Pyrrolo[1,2-Alpha]Indole-4,7-Dione
• mitomycin C from streptomyces*caespitosus
• tomycin C
• azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-8-(((aminocarbonyl)oxy
• 8aalpha,8balpha))-(9ci)
• azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)ox
• 8balpha)]-8aalph
• azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-1,1a,2,8,8a,8b-hexahy
• mitomycynac
• )methyl)-1,1a,2,8,8a,8b-hexahydro-8-a-methoxy-5-methyl-,(1as-(1aalpha,8beta,
• 7-amino-9-alpha-methoxymitosane
• AMETYCIN
• MITOMYCIN
• mitomycynac(polish)

Ametycin

CAS: 50-07-7

Formula: C₁₅H₁₈N₄O₅

Purity: >98.0%(HPLC)

Color and Shape: Dark red to Dark purple to Dark blue powder to crystal

Molecular weight: 334.33

Ref: 3B-M2320

Mitomycin C, 5 mg/ml in DMSO, sterile-filtered

CAS: 50-07-7

Mitomycin C, 50-07-7, is an antibiotic and anti-tumor agent which inhibits DNA synthesis by forming DNA crosslinks. Learn more at Thermo Fisher Scientific.

Formula: C₁₅H₁₈N₄O₅

Color and Shape: Liquid

Molecular weight: 334.33

Ref: 02-J67460

MITOMYCIN CRS

CAS: 50-07-7

MITOMYCIN CRS

Color and Shape: Powder

Ref: 41-Y0000378

Mitomycin

CAS: 50-07-7

Antibiotics nesoi

Formula: C₁₅H₁₈N₄O₅

Color and Shape: Blue Violet Powder

Molecular weight: 334.12772

Ref: 45-1444707

Mitomycin C

CAS: 50-07-7

Formula: C₁₅H₁₈N₄O₅

Color and Shape: Blue-Violet Solid

Molecular weight: 334.33

Ref: 4Z-M-841

Mitomycin C, 4% (with sodium chloride)

CAS: 50-07-7

Formula: C₁₅H₁₈N₄O₅

Color and Shape: Grey to blue-purple powder

Molecular weight: 334.33

Ref: 7W-GP3729

Mitomycin C

CAS: 50-07-7

Formula: C₁₅H₁₈N₄O₅

Purity: (HPLC) ≥ 98.0%

Color and Shape: Grey, violet or blue powder

Molecular weight: 334.33

Ref: 7W-GA9147

Mitomycin C

CAS: 50-07-7

Mitomycin C

Formula: C₁₅H₁₈N₄O₅

Purity: By hplc: 99.1% (Typical Value in Batch COA)

Color and Shape: blue-violet solid

Molecular weight: 334.33g/mol

Ref: 54-BIM0133

Mitomycin C

CAS: 50-07-7

Mitomycin C (Ametycine) is an antineoplastic agent and DNA double-strand crosslinking agent capable of inducing DNA damage, inhibiting DNA synthesis, suppressing mitosis, and activating apoptosis. Mitomycin C is a broad-spectrum antibiotic against both Gram-negative and Gram-positive bacteria.

Formula: C₁₅H₁₈N₄O₅

Purity: 99.35%

Color and Shape: Solid

Molecular weight: 334.37

Ref: TM-T6890

Mitomycin

Controlled Product

CAS: 50-07-7

Formula: C₁₅H₁₈N₄O₅

Color and Shape: Neat

Molecular weight: 334.33

Ref: 86-MM1308.00

Mitomycin 100 µg/mL in Acetonitrile

Controlled Product

CAS: 50-07-7

Formula: C₁₅H₁₈N₄O₅

Color and Shape: Single Solution

Molecular weight: 334.33

Ref: 04-A15273000AL-100

Mitomycin

Controlled Product

CAS: 50-07-7

Formula: C₁₅H₁₈N₄O₅

Color and Shape: Neat

Molecular weight: 334.33

Ref: 04-C15273000

Mitomycin C

Controlled Product

CAS: 50-07-7

Stability Hygroscopic
Applications Mitomycin C is an antitumor antibiotic. It is antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 16, 361 (1986),

Formula: C₁₅H₁₈N₄O₅

Color and Shape: Violet

Molecular weight: 334.33

Ref: TR-M371900

Mitomycin C - Bio-X ™

CAS: 50-07-7

Mitomycin C is a cytotoxic agent that belongs to the class of mitomycins. It has been used for the treatment of a range of cancers and for ocular surface diseases, such as the glaucoma surgery trabeculectomy. In this case it is administered to reduce post-operative scarring which could otherwise lead to failure of the procedure. Mitomycin C is an alkylating antibiotic that inhibits DNA synthesis by cross-linking the DNA double helix. Mitomycin C also stimulates the production of transforming growth factor β1 (TGF-β1) and basic fibroblast growth factor (bFGF). Clinically, mitomycin can be used both intravenously and topically, and has been studied in a range of wound healing models.

Formula: C₁₅H₁₈N₄O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 334.33 g/mol

Ref: 3D-BM164668

Mitomycin C

CAS: 50-07-7

Chemoterapeutic agent; DNA crosslinker

Formula: C₁₅H₁₈N₄O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 334.33 g/mol

Ref: 3D-AM26019

Mitomycin C - High Purity

CAS: 50-07-7

Mitomycin C is a cytotoxic agent that inhibits DNA synthesis. This product is tested according to USP specification. Mitomycin C has been shown to be effective against resistant mutants and carcinoma cell lines. It also has genotoxic activity and induces statistically significant chromosome aberrations in mammalian cells. Mitomycin C is toxic to the mitochondria, which may be due to its ability to induce mitochondrial membrane potential collapse, leading to apoptosis. Mitomycin C binds to the response element in the genome, causing transcriptional repression of a number of genes involved in cell proliferation, differentiation, or apoptosis. Mitomycin C inhibits squamous carcinoma cells by binding to their DNA and preventing RNA synthesis.

Formula: C₁₅H₁₈N₄O₅

Purity: Cas Rn [50-07-7] M. F. C15H18N4O5

Color and Shape: Powder

Molecular weight: 334.33 g/mol

Ref: 3D-AM161650

Mitomycin

CAS: 50-07-7

Color and Shape: Neat

Ref: 61-FOR1308.00