CAS 50-35-1

Thalidomide

Description:

Thalidomide, with the CAS number 50-35-1, is a synthetic compound originally developed in the late 1950s as a sedative and later prescribed for morning sickness in pregnant women. It is classified as a phthalimide derivative and has a molecular formula of C13H10N2O4. Thalidomide is known for its unique mechanism of action, which includes immunomodulatory effects, anti-inflammatory properties, and inhibition of angiogenesis. Its structure features a chiral center, leading to two enantiomers, one of which is associated with the drug's therapeutic effects, while the other is linked to severe teratogenic effects, resulting in birth defects when taken during pregnancy. Due to these risks, thalidomide was withdrawn from the market in the early 1960s. However, it has since been repurposed and is now used under strict regulations for the treatment of certain conditions, such as multiple myeloma and leprosy-related complications. Its use is closely monitored due to its potential side effects, including peripheral neuropathy and thromboembolic events.

Formula: C₁₃H₁₀N₂O₄

InChI: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

InChI key: InChIKey=UEJJHQNACJXSKW-UHFFFAOYSA-N

SMILES: O=C1N(C(=O)C=2C1=CC=CC2)C3C(=O)NC(=O)CC3

Synonyms:

• 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline
• 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
• 2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione
• 2-(2,6-Dioxo-piperidin-3-yl)-isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione
• 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
• 2-Phthalimidoglutarimide
• 3-Phthalimidoglutarimide
• Celgene
• Contergan
• Distaval
• Immunoprin
• K 17
• Kevadon
• Myrin
• N-(2,6-Dioxo-3-piperidinyl)phthalimide
• N-(2,6-Dioxo-3-piperidyl)phthalimide
• N-Phthaloylglutamimide
• Neurosedyn
• Nsc 527179
• Nsc 66847
• Pantosediv
• Pharmion
• Phthalimide, N-(2,6-dioxo-3-piperidyl)-
• Quetimid
• Sauramide
• Sedalis
• Sedoval
• Softenil
• Softenon
• Suaramide
• Synovir
• Talidomida
• Talimol
• Talinol
• Thaled
• Thalidomid
• Thalomid
• α-(N-Phthalimido)glutarimide
• α-N-Phthalylglutaramide

(±)-Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 258.23

Ref: 3B-T2524

(+/-)-Thalidomide, 99+%

CAS: 50-35-1

Teratogenic compound found to inhibit HIV-1 replication and FGF-induced angiogenesis

Formula: C₁₃H₁₀N₂O₄

Purity: 99+%

Color and Shape: White to cream, Powder

Molecular weight: 258.23

Ref: 02-J62266

Thalidomide

CAS: 50-35-1

Teratogenic compound found to inhibit HIV-1 replication and FGF-induced angiogenesis

Formula: C₁₃H₁₀N₂O₄

Molecular weight: 258.23

Ref: 02-J60271

Thalidomide

CAS: 50-35-1

Imides and their derivatives (excluding sacharin), and salts thereof

Formula: C₁₃H₁₀N₂O₄

Color and Shape: White Off-White Powder

Molecular weight: 258.06406

Ref: 45-1652500

Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 258.2295

Ref: IN-DA006UNO

Thalidomide

CAS: 50-35-1

Thalidomide, a glutamic acid derivative, has teratogenic and immunomodulatory effects.

Formula: C₁₃H₁₀N₂O₄

Purity: 98.88% - 99.88%

Color and Shape: White Solid

Molecular weight: 258.23

Ref: TM-T0213

Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 258.23

Ref: 4Z-T-232

Thalidomide

CAS: 50-35-1

Thalidomide

Purity: ≥98%

Molecular weight: 258.23g/mol

Ref: 54-BUP17698

Thalidomide-d4

CAS: 50-35-1

Formula: C₁₃H₆D₄N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 262.26

Ref: 4Z-T-231

Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Purity: ≤ 0.1%

Color and Shape: White to off-white powder

Molecular weight: 258.23

Ref: 7W-GP4232

Thalidomide

CAS: 50-35-1

Thalidomide

Purity: 98%

Molecular weight: 258.23g/mol

Ref: 54-OR1029278

Thalidomide

Controlled Product

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Color and Shape: Neat

Molecular weight: 258.23

Ref: 86-MM0940.00

(±)-Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Molecular weight: 258.23

Ref: ST-EA-CP-P25030

(+/-)-Thalidomide - Bio-X ™

Controlled Product

CAS: 50-35-1

Thalidomide is a piperidinyl isoindole drug that is used to treat various cancers such as myeloma and erythema nodosum leprosum. This drug is immunosuppressive and has anti-angiogenic activity. Thalidomide’s mechanism of action is not fully understood however it is thought to block the activity of tumor necrosis factor-alpha (TNF-α).

Formula: C₁₃H₁₀N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 258.23 g/mol

Ref: 3D-BT164465

(+/-)-Thalidomide

Controlled Product

CAS: 50-35-1

Classified as immunomodulatory drug, thalidomide suppresses the expression of tumor necrosis factor-alpha (TNF-α), interferes with a cascade of pro-inflammatory cytokines, and interferes with the secretion of vascular endothelial growth factor (VEGF) and beta fibroblast growth factor (bFGF). Similarly to apremilast, thalidomide carries a phthalimide ring, together with a glutarimide ring that is specifically recognized by the target molecule cereblon. Thanks to its ability to contrast neoangiogenesis and the modifications of the bone marrow stromal microenvironment, thalidomide is a powerful tool to fight hematologic cancers. In the treatment of SARS-CoV-2, the immunomodulatory and anti-inflammatory action of thalidomide has and has proved beneficial when combined with a low-dose glucocorticoid.

Formula: C₁₃H₁₀N₂O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 258.23 g/mol

Ref: 3D-FT15648

(+/-)-Thalidomide

CAS: 50-35-1

M02554 - (+/-)-Thalidomide

Formula: C₁₃H₁₀N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 258.233

Ref: 10-M02554

Thalidomide

Controlled Product

CAS: 50-35-1

Applications Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994), Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993), Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)

Formula: C₁₃H₁₀N₂O₄

Color and Shape: Neat

Molecular weight: 258.23

Ref: TR-T338850

Thalidomide

CAS: 50-35-1

Color and Shape: Neat

Ref: 61-FOR0940.00