CAS 50-35-1: Thalidomide

Description: Thalidomide, with the CAS number 50-35-1, is a synthetic compound originally developed in the late 1950s as a sedative and later prescribed for morning sickness in pregnant women. It is classified as a phthalimide derivative and has a molecular formula of C13H10N2O4. Thalidomide is known for its unique mechanism of action, which includes immunomodulatory effects, anti-inflammatory properties, and inhibition of angiogenesis. Its structure features a chiral center, leading to two enantiomers, one of which is associated with the drug's therapeutic effects, while the other is linked to severe teratogenic effects, resulting in birth defects when taken during pregnancy. Due to these risks, thalidomide was withdrawn from the market in the early 1960s. However, it has since been repurposed and is now used under strict regulations for the treatment of certain conditions, such as multiple myeloma and leprosy-related complications. Its use is closely monitored due to its potential side effects, including peripheral neuropathy and thromboembolic events.

Formula: C₁₃H₁₀N₂O₄

InChI: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

InChI key: InChIKey=UEJJHQNACJXSKW-UHFFFAOYSA-N

SMILES: O=C1NC(=O)C(N2C(=O)C=3C=CC=CC3C2=O)CC1

Synonyms:

• 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline
• 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
• 2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione
• 2-(2,6-Dioxo-piperidin-3-yl)-isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione
• 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
• 2-Phthalimidoglutarimide
• 3-Phthalimidoglutarimide
• Celgene
• Contergan
• Distaval
• Immunoprin
• K 17
• Kevadon
• Myrin
• N-(2,6-Dioxo-3-piperidinyl)phthalimide
• N-(2,6-Dioxo-3-piperidyl)phthalimide
• N-Phthaloylglutamimide
• Neurosedyn
• Nsc 527179
• Nsc 66847
• Pantosediv
• Pharmion
• Phthalimide, N-(2,6-dioxo-3-piperidyl)-
• Quetimid
• Sauramide
• Sedalis
• Sedoval
• Softenil
• Softenon
• Suaramide
• Synovir
• Talidomida
• Talimol
• Talinol
• Thaled
• Thalidomid
• Thalomid
• α-(N-Phthalimido)glutarimide
• α-N-Phthalylglutaramide
• α-Phthalimidoglutarimide

(±)-Thalidomide

CAS: 50-35-1

• Formula: C₁₃H₁₀N₂O₄
• Purity: >98.0%(HPLC)(N)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 258.23

(+/-)-Thalidomide, 99+%

CAS: 50-35-1

Teratogenic compound found to inhibit HIV-1 replication and FGF-induced angiogenesis This Thermo Scientific Chemicals brand …

• Formula: C₁₃H₁₀N₂O₄
• Purity: 99+%
• Color and Shape: White to cream, Powder
• Molecular weight: 258.23

Thalidomide

CAS: 50-35-1

Teratogenic compound found to inhibit HIV-1 replication and FGF-induced angiogenesis This Thermo Scientific Chemicals brand …

• Formula: C₁₃H₁₀N₂O₄
• Molecular weight: 258.23

Thalidomide

CAS: 50-35-1

Imides and their derivatives (excluding sacharin), and salts thereof

• Formula: C₁₃H₁₀N₂O₄
• Color and Shape: White Off-White Powder
• Molecular weight: 258.06406

Thalidomide

CAS: 50-35-1

• Formula: C₁₃H₁₀N₂O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 258.2295

Thalidomide

CAS: 50-35-1

Thalidomide, a glutamic acid derivative, has teratogenic and immunomodulatory effects.

• Formula: C₁₃H₁₀N₂O₄
• Purity: 98.88% - 99.88%
• Color and Shape: White Solid
• Molecular weight: 258.23

Thalidomide-d4

CAS: 50-35-1

• Formula: C₁₃H₆D₄N₂O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 262.26

Thalidomide

CAS: 50-35-1

• Formula: C₁₃H₁₀N₂O₄
• Purity: ≤ 0.1%
• Color and Shape: White to off-white powder
• Molecular weight: 258.23

Thalidomide

CAS: 50-35-1

• Molecular weight: 258.23g/mol

Thalidomide

CAS: 50-35-1

• Formula: C₁₃H₁₀N₂O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 258.23

Thalidomide

CAS: 50-35-1

• Purity: 99%
• Molecular weight: 258.23g/mol

Thalidomide

CAS: 50-35-1

• Formula: C₁₃H₁₀N₂O₄
• Color and Shape: Neat
• Molecular weight: 258.23

(+/-)-Thalidomide

CAS: 50-35-1

M02554 - (+/-)-Thalidomide

• Formula: C₁₃H₁₀N₂O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 258.2330017089844

(+/-)-Thalidomide - Bio-X ™

CAS: 50-35-1

Thalidomide is a piperidinyl isoindole drug that is used to treat various cancers such as …

• Formula: C₁₃H₁₀N₂O₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 258.23 g/mol

(+/-)-Thalidomide

CAS: 50-35-1

Classified as immunomodulatory drug, thalidomide suppresses the expression of tumor necrosis factor-alpha (TNF-α), interferes with …

• Formula: C₁₃H₁₀N₂O₄
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 258.23 g/mol

Thalidomide

CAS: 50-35-1

Applications Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There …

• Formula: C₁₃H₁₀N₂O₄
• Color and Shape: Neat
• Molecular weight: 258.23