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CAS 50-41-9

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Clostilbegit

Description:
Clostilbegit, also known as clomiphene citrate, is a non-steroidal fertility medication primarily used to treat ovulatory dysfunction in women. It acts as a selective estrogen receptor modulator (SERM), influencing the hypothalamic-pituitary-gonadal axis to stimulate ovulation. Clostilbegit is characterized by its ability to bind to estrogen receptors, thereby blocking the negative feedback of estrogen on the hypothalamus, which leads to increased secretion of gonadotropins (LH and FSH) from the pituitary gland. This promotes ovarian follicle development and ovulation. The substance is typically administered orally and is known for its relatively low side effect profile, although it can cause symptoms such as hot flashes, mood swings, and ovarian hyperstimulation in some cases. Clostilbegit is often prescribed in cycles and is considered a first-line treatment for women experiencing infertility due to anovulation. Its chemical structure includes a triphenylethylene backbone, contributing to its unique pharmacological properties. As with any medication, it is essential to use Clostilbegit under medical supervision to monitor for efficacy and potential adverse effects.
Formula:C26H28ClNO·C6H8O7
InChI:InChI=1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChI key:InChIKey=PYTMYKVIJXPNBD-UHFFFAOYSA-N
SMILES:C(=C(Cl)C1=CC=CC=C1)(C2=CC=C(OCCN(CC)CC)C=C2)C3=CC=CC=C3.C(CC(O)=O)(CC(O)=O)(C(O)=O)O
Synonyms:
  • 1-[p-(β-Diethylaminoethoxy)phenyl]-1,2-diphenyl-2-chloroethylene citrate
  • 2-(4-(2-Chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate
  • 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine citrate
  • 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
  • 2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine dihydrogen citrate
  • 2-{4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy}-N,N-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)
  • 2-{4-[(Z)-2-chloro-1,2-diphenylethenyl]phenoxy}-N,N-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)
  • Chloramiphene
  • Clomephene Citrate
  • Clomhexal
  • See more synonyms
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