CAS 50-44-2
:6-Mercaptopurine
Description:
6-Mercaptopurine is a purine analog and an antimetabolite used primarily in the treatment of certain types of leukemia, particularly acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML). Its chemical formula is C5H4N4S, and it features a thiol group (-SH) that contributes to its reactivity and biological activity. The compound acts by inhibiting nucleotide synthesis, thereby interfering with DNA and RNA synthesis, which is crucial for rapidly dividing cancer cells. 6-Mercaptopurine is typically administered orally and is known for its potential side effects, including myelosuppression, hepatotoxicity, and gastrointestinal disturbances. It is metabolized in the liver, and its efficacy can be influenced by genetic variations in metabolic enzymes, particularly thiopurine S-methyltransferase (TPMT). Due to its mechanism of action and side effect profile, careful monitoring and dosage adjustments are often necessary during treatment. Overall, 6-Mercaptopurine remains an important therapeutic agent in oncology, particularly in pediatric and adult hematological malignancies.
Formula:C5H4N4S
InChI:InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI key:InChIKey=GLVAUDGFNGKCSF-UHFFFAOYSA-N
SMILES:S=C1C2=C(NC=N1)N=CN2
Synonyms:- 1,7-Dihydro-6H-purine-6-thione
- 1,9-Dihydro-6H-purine-6-thione
- 1,9-Dihydro-purine-6-thione
- 1H-Purine, 6-mercapto-
- 3,5-dihydro-6H-purine-6-thione
- 3,7-Dihydropurine-6-thione
- 3H-Purine-6-thiol
- 6,9-dihydro-1H-purine
- 6-Mercaptopurin
- 6-Mercaptopurine
- 6-Mp
- 6-Thiohypoxanthine
- 6-Thiopurine
- 6-Thioxopurine
- 6H-Purine-6-thione, 1,7-dihydro-
- 6H-Purine-6-thione, 1,9-dihydro-
- 6H-purine-6-thione
- 6MP
- 7-Mercapto-1,3,4,6-tetrazaindene
- 9H-Purine-6(1H)-thione
- Hypoxanthine, thio-
- Ismipur
- Leukerin
- Leupurin
- Mercaleukim
- Mercaleukin
- Mercaptopurin
- Mercaptopurina
- Mercapurin
- Mern
- Nsc 55477
- Nsc 68293
- Nsc 755
- Purimethol
- Purine-6(1H)-thione
- Purine-6-Thiol
- Purine-6-thione
- Purinethiol
- Purinethol
- Purixan
- Thiohypoxanthine
- See more synonyms
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6-Mercaptopurine
CAS:6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.Formula:C5H4N4SPurity:99.53% - 99.63%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:152.186-Mercaptopurine
CAS:6-MercaptopurineFormula:C5H4N4SPurity:98%Color and Shape:Pale yellow SolidMolecular weight:152.177056-Mercaptopurine-13C-15N2 (Azathioprine EP Impurity B-13C-15N2)
CAS:Formula:C413CH4N215N2SMolecular weight:155.156-Mercaptopurine (Azathioprine EP Impurity B)
CAS:Formula:C5H4N4SColor and Shape:Yellow SolidMolecular weight:152.186-Mercaptopurine (Standard)
CAS:6-Mercaptopurine (Standard) is a reference standard for research and analysis in studies involving 6-Mercaptopurine. 6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.Formula:C5H4N4SMolecular weight:152.186-Mercaptopurine
CAS:6-Mercaptopurine is an antigen binding molecule that is biocompatible with the human body. It binds to 6-mercaptopurine and inhibits the oxidation of proteins. The inhibition of protein oxidation has been shown to decrease disease activity in patients with inflammatory bowel disease. 6-Mercaptopurine also inhibits the production of inhibitor molecules, which are responsible for the development of cardiac effects such as arrhythmias and cardiomyopathy. 6-Mercaptopurine has inhibitory properties against polymerase chain reactions, which may be due to its ability to bind with protein thiols at high rates.Formula:C5H4N4SPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:152.18 g/mol
