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CAS 50-54-4

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Quinidine sulfate

Description:
Quinidine sulfate is an alkaloid derived from the bark of the cinchona tree and is primarily used as an antiarrhythmic medication. It is a stereoisomer of quinine and is known for its ability to stabilize cardiac rhythm by blocking sodium channels in cardiac tissues. Quinidine sulfate appears as a white to off-white crystalline powder and is soluble in water, making it suitable for intravenous administration. The compound exhibits a bitter taste and has a molecular formula that reflects its complex structure, which includes multiple chiral centers. Its pharmacological effects are attributed to its ability to prolong the action potential duration and refractory period in cardiac tissues, making it effective in treating certain types of arrhythmias. However, it can also have side effects, including gastrointestinal disturbances and potential cardiotoxicity, necessitating careful monitoring during use. Quinidine sulfate is typically administered under medical supervision, and its dosage must be tailored to the individual patient's needs.
Formula:C20H24N2O2H2O4S
InChI:InChI=1S/C20H24N2O2.H2O4S/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4)/t13-,14-,19+,20-;/m0./s1
InChI key:InChIKey=AKYHKWQPZHDOBW-VJAUXQICSA-N
SMILES:S(=O)(=O)(O)O.[C@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@@]3([N@@]4C[C@H](C=C)[C@](C3)(CC4)[H])[H]
Synonyms:
  • (9S)-6'-methoxycinchonan-9-ol sulfate (2:1)
  • (9S)-6'-methoxycinchonan-9-ol sulfate (salt)
  • Chinidine sulfate
  • Cinchonan-9-ol, 6′-methoxy-, (9S)-, sulfate (2:1)
  • Cinchonan-9-ol, 6′-methoxy-, (9S)-, sulfate (2:1) (salt)
  • NSC 10004
  • Quinicardine
  • Quinidate
  • Quinidex
  • Quinidine monosulfate
  • See more synonyms
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