CAS 50-59-9

Cephaloridine

Description:

Cephaloridine is a semi-synthetic antibiotic belonging to the cephalosporin class, primarily used for its antibacterial properties. It is effective against a range of Gram-positive and some Gram-negative bacteria, making it useful in treating various infections. The compound is characterized by its beta-lactam structure, which is essential for its mechanism of action, as it inhibits bacterial cell wall synthesis. Cephaloridine is typically administered via injection due to its poor oral bioavailability. It has a relatively short half-life, necessitating multiple doses for effective treatment. The substance is known to have potential side effects, including allergic reactions, gastrointestinal disturbances, and nephrotoxicity, particularly in patients with pre-existing kidney conditions. As with other antibiotics, the emergence of resistant bacterial strains poses a challenge to its efficacy. Cephaloridine's chemical formula and structure contribute to its pharmacological properties, and it is important to use it judiciously to minimize resistance development. Overall, cephaloridine remains a significant agent in the antibiotic arsenal, particularly in specific clinical scenarios.

Formula: C₁₉H₁₇N₃O₄S₂

InChI: InChI=1/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)

InChI key: InChIKey=CZTQZXZIADLWOZ-CRAIPNDOSA-N

SMILES: C([O-])(=O)C=1N2[C@@]([C@H](NC(CC3=CC=CS3)=O)C2=O)(SCC1C[N+]=4C=CC=CC4)[H]

Synonyms:

• (6R,7R)-8-oxo-3-(pyridinium-1-ylmethyl)-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 7-[α-(2-Thienyl)acetamido]-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine
• 8-Oxo-3-(Pyridinium-1-Ylmethyl)-7-[(Thiophen-2-Ylacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
• Aliporina
• Ampligram
• Cefaloridin
• Cefaloridina
• Ceflorin
• Cepaloridin
• Cepalorin
• Ceph 87/4
• Cephaloridin
• Cephaloridine
• Cephlodine
• Ceporan
• Ceporin
• Ceporine
• Cer
• Cilifor
• Deflorin
• Faredina
• Floridin
• Glaxoridin
• Intrasporin
• Keflodin
• Keflordin
• Kefspor
• Lilly 40602
• Lloncefal
• Loridine
• Pyridinium, 1-[[(6R,7R)-2-carboxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt
• Pyridinium, 1-[[(6R,7R)-2-carboxy-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt
• Pyridinium, 1-[[2-carboxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, hydroxide, inner salt, (6R-trans)-
• Pyridinium, 1-[[2-carboxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, (6R-trans)-
• Pyridinium, 1-[[2-carboxy-8-oxo-7-[2-(2-thienyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, hydroxide, inner salt
• Sch 11527
• Sefacin
• (6R,7R)-8-Oxo-3-(1-pyridiniumylmethyl)-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• N-(7-[2′-Thienylacetamidoceph-3-ylmethyl])pyridinium 2-carboxylate
• Cephaloridine II
• pyridinium, 1-((2-carboxy-8-oxo-7-(2-(2-thienyl)acetamido)-5-thia-1-azabicyclo( 4.2.0)o ct- 2-en-3-yl)methyl)-, hydroxide, inner salt 1-[(7'-beta-[2-(2-thienyl)acetamido]-8'-oxo-1'-aza-5'-t hiabicyclo[4.2.0]-oct-2 '-en-3'-yl)methyl]pyridinium-2'-carboxylate 40602 7-((2-thienyl)acetamido)-3-(1-pyridylmethyl)cephalosporanic acid 7-(alpha-(2-thienyl)acetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid 7-(alpha-(2-thienyl)acetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid b etaine
• (6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• N-[7-[2'-Thienyl-acetamidoceph-3-ylmethyl]] pyridinium-4-carboxylate
• PyridiniuM,1-[[(6R,7R)-2-carboxy-8-oxo-7-[[2-(2-thienyl)acetyl]aMino]-5-thia-1-azabicyclo[4.2.0]oct-

Cefaloridine

CAS: 50-59-9

Cefaloridine: first-gen cephalosporin derivative, zwitterionic, treats pneumococcal pneumonia, effective against staph and strep.

Formula: C₁₉H₁₇N₃O₄S₂

Purity: 98%

Color and Shape: Crystals Solid

Molecular weight: 415.49

Ref: TM-T19678