CAS 50-63-5
:(±)-Chloroquine diphosphate
Description:
(±)-Chloroquine diphosphate is a synthetic compound primarily known for its use as an antimalarial agent. It belongs to the class of 4-aminoquinolines and is characterized by its ability to interfere with the growth of the malaria parasite by inhibiting heme polymerization, which is crucial for the parasite's survival. The compound exhibits a chiral nature, with two enantiomers, which can influence its pharmacological activity and side effects. In addition to its antimalarial properties, chloroquine has been investigated for potential antiviral effects and as an immunomodulatory agent in various autoimmune diseases. The diphosphate salt form enhances its solubility and stability in aqueous solutions, making it suitable for pharmaceutical formulations. Chloroquine is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in some cases. However, its use has been associated with side effects, including gastrointestinal disturbances and potential retinal toxicity with long-term use. As with any medication, careful consideration of its benefits and risks is essential in clinical settings.
Formula:C18H32ClN3O8P2
InChI:InChI=1/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChI key:InChIKey=AEUAEICGCMSYCQ-UHFFFAOYSA-N
SMILES:P(=O)(O)(O)O.N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2
Synonyms:- 1,4-Pentanediamine, N<sup>4</sup>-(7-chloro-4-quinolinyl)-N<sup>1</sup>,N<sup>1</sup>-diethyl-, phosphate (1:2)
- 3377 Rp
- 3377Rp
- 7-Chlor-4-(4-diaethylamino)-1-methylbutylamino)-chinolindiphosphat
- 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
- 7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate
- Ai3-14952
- Alermine
- Alexoquine
- Aralen diphosphate
- Aralen phosphate
- Arechin
- Avloclor
- Bemaphate
- Chingamin
- Chingamin phosphate
- Chlorochin diphosphate
- Chloroquin diphosphate
- Chloroquine bis(phosphate)
- Chloroquine dihydrogen phosphate (1:2)
- Chloroquine phosphate
- Cidoquine
- Delagil
- Gontochin phosphate
- Imagon
- Khingamin
- Maladrin
- Malaquin
- NSC 14050
- Nivaquine B
- N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine phosphate (1:2)
- Quingamine
- Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, phosphate (1:2) (8CI)
- Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, diphosphate
- Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate
- Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-, phosphate (1:2)
- Quivaclor
- Resochin
- Resoquine
- Sanoquin
- Sn 7618
- Tanakan
- Tanakan (antimalarial)
- Tresochin
- Unii-6E17K3343P
- Wr 1522
- chloroquin Phosphate
- dl-Chloroquine diphosphate
- 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2)
- 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-quinolindiphosphate
- 7-CHLORO-4-OXO-1H-QUINOLINE-3-CARBOXYLIC ACID
- N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIMETHYL-1,4-PENTANEDIAMINE DIPHOSPHATE SALT
- gontochinphosphate
- chingaminphosphate
- klorokinfosfat
- h-stadur
- CHLOROQUINE DIPHOSPHATE SALT
- chloroquindiphosphate
- 7-chloro-4-((4’-diethylamino-1-methylbutyl)amino)quinolinediphosphate
- chloroquinebis(phosphate)
- aralendiphosphate
- N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIMETHYL-1,4-PENTANEDIAMINE DIPHOSPHATE
- n-(7-chloro-4-quinolinyl)-n,n-dimethyl-1,4-pentanediamine diphosphate salt
- See more synonyms
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Found 20 products.
Chloroquine Diphosphate
CAS:Formula:C18H26ClN3·2H3PO4Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:515.86Chloroquine diphosphate salt, 98%
CAS:<p>Chloroquine diphosphate salt, 50-63-5, is a non-steroidal agent and DNA intercalator which exhibits antimalarial and anti-inflammatory properties. Learn more.</p>Formula:C18H32ClN3O8P2Purity:98%Color and Shape:Powder or crystals or crystalline powder, White to off-whiteMolecular weight:515.86CHLOROQUINE PHOSPHATE FOR PEAK IDENTIFICATION CRS
CAS:CHLOROQUINE PHOSPHATE FOR PEAK IDENTIFICATION CRSChloroquine phosphate
CAS:Chloroquine phosphateFormula:C18H26ClN3H3PO4Purity:98.4%Color and Shape:Light BrownMolecular weight:417.15842Chloroquine Phosphate
CAS:Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fusedFormula:C18H26ClN3·2H3PO4Color and Shape:Yellow PowderMolecular weight:515.13532Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)
CAS:Formula:C18H30ClN3O7P2Purity:98%Color and Shape:SolidMolecular weight:497.8472Chloroquine phosphate
CAS:<p>Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is used as an autophagy inhibitor. Chloroquine also is an inhibitor of TLRs.</p>Formula:C18H26CLN3·2(H3PO4)Purity:99.64% - ≥95%Color and Shape:White To Slightly Yellow Crystalline Powder White SolidMolecular weight:515.87Chloroquine diphosphate salt
CAS:Formula:C18H26ClN3·2H3PO4Purity:(Titration) 98.0 - 102.0 % (dried basis)Color and Shape:White or almost white crystalline powderMolecular weight:515.87Chloroquine Diphosphate
CAS:Formula:C18H26ClN3·2H3O4PColor and Shape:White To Off-White SolidMolecular weight:319.88 2*97.99Chloroquine-d5 Diphosphate
CAS:Formula:C18H21D5ClN3·2H3O4PColor and Shape:White To Off-White SolidMolecular weight:324.91 2*97.99Chloroquine-d4 Phosphate Salt
CAS:Controlled Product<p>Applications Labelled anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product.<br>References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),<br></p>Formula:C18H22D4ClN3•xH3PO4Color and Shape:Yellow SolidMolecular weight:323.9098Chloroquine Diphosphate Salt
CAS:<p>Stability Hygroscopic<br>Applications Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product.<br>References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),<br></p>Formula:C18H26ClN3·2H3O4PColor and Shape:Light BrownMolecular weight:515.86Chloroquine diphosphate
CAS:Controlled Product<p>Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine i a schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the S-glycoprotein.</p>Formula:C18H32ClN3O8P2Color and Shape:White Off-White PowderMolecular weight:515.86 g/molChloroquine Diphosphate
CAS:Formula:C18H32ClN3O8P2Purity:98%Color and Shape:SolidMolecular weight:515.86
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