CAS 50-63-5

(±)-Chloroquine diphosphate

Description:

(±)-Chloroquine diphosphate is a synthetic compound primarily known for its use as an antimalarial agent. It belongs to the class of 4-aminoquinolines and is characterized by its ability to interfere with the growth of the malaria parasite by inhibiting heme polymerization, which is crucial for the parasite's survival. The compound exhibits a chiral nature, with two enantiomers, which can influence its pharmacological activity and side effects. In addition to its antimalarial properties, chloroquine has been investigated for potential antiviral effects and as an immunomodulatory agent in various autoimmune diseases. The diphosphate salt form enhances its solubility and stability in aqueous solutions, making it suitable for pharmaceutical formulations. Chloroquine is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in some cases. However, its use has been associated with side effects, including gastrointestinal disturbances and potential retinal toxicity with long-term use. As with any medication, careful consideration of its benefits and risks is essential in clinical settings.

Formula: C₁₈H₃₂ClN₃O₈P₂

InChI: InChI=1/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

InChI key: InChIKey=AEUAEICGCMSYCQ-UHFFFAOYSA-N

SMILES: P(=O)(O)(O)O.N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Synonyms:

• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹,N¹-diethyl-, phosphate (1:2)
• 3377 Rp
• 3377Rp
• 7-Chlor-4-(4-diaethylamino)-1-methylbutylamino)-chinolindiphosphat
• 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
• 7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate
• Ai3-14952
• Alermine
• Alexoquine
• Aralen diphosphate
• Aralen phosphate
• Arechin
• Avloclor
• Bemaphate
• Chingamin
• Chingamin phosphate
• Chlorochin diphosphate
• Chloroquin diphosphate
• Chloroquine bis(phosphate)
• Chloroquine dihydrogen phosphate (1:2)
• Chloroquine phosphate
• Cidoquine
• Delagil
• Gontochin phosphate
• Imagon
• Khingamin
• Maladrin
• Malaquin
• NSC 14050
• Nivaquine B
• N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine phosphate (1:2)
• Quingamine
• Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, phosphate (1:2) (8CI)
• Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, diphosphate
• Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate
• Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-, phosphate (1:2)
• Quivaclor
• Resochin
• Resoquine
• Sanoquin
• Sn 7618
• Tanakan
• Tanakan (antimalarial)
• Tresochin
• Unii-6E17K3343P
• Wr 1522
• chloroquin Phosphate
• dl-Chloroquine diphosphate
• 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2)
• 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-quinolindiphosphate
• 7-CHLORO-4-OXO-1H-QUINOLINE-3-CARBOXYLIC ACID
• N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIMETHYL-1,4-PENTANEDIAMINE DIPHOSPHATE SALT
• gontochinphosphate
• chingaminphosphate
• klorokinfosfat
• h-stadur
• CHLOROQUINE DIPHOSPHATE SALT
• chloroquindiphosphate
• 7-chloro-4-((4’-diethylamino-1-methylbutyl)amino)quinolinediphosphate
• chloroquinebis(phosphate)
• aralendiphosphate
• N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIMETHYL-1,4-PENTANEDIAMINE DIPHOSPHATE
• n-(7-chloro-4-quinolinyl)-n,n-dimethyl-1,4-pentanediamine diphosphate salt

Chloroquine Diphosphate

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃·2H₃PO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 515.86

Ref: 3B-C2301

Chloroquine diphosphate salt, 98%

CAS: 50-63-5

Chloroquine diphosphate salt, 50-63-5, is a non-steroidal agent and DNA intercalator which exhibits antimalarial and anti-inflammatory properties. Learn more.

Formula: C₁₈H₃₂ClN₃O₈P₂

Purity: 98%

Color and Shape: Powder or crystals or crystalline powder, White to off-white

Molecular weight: 515.86

Ref: 02-J64459

Chloroquine Phosphate

CAS: 50-63-5

Color and Shape: Neat

Ref: 61-FOR1055.00

CHLOROQUINE PHOSPHATE FOR PEAK IDENTIFICATION CRS

CAS: 50-63-5

CHLOROQUINE PHOSPHATE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002448

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate

Formula: C₁₈H₂₆ClN₃H₃PO₄

Purity: 98.4%

Color and Shape: Light Brown

Molecular weight: 417.15842

Ref: 47-1314

Chloroquine Phosphate

CAS: 50-63-5

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Formula: C₁₈H₂₆ClN₃·2H₃PO₄

Color and Shape: Yellow Powder

Molecular weight: 515.86

Ref: 45-1118000

Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)

CAS: 50-63-5

Formula: C₁₈H₃₀ClN₃O₇P₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 497.8472

Ref: IN-DA0034LP

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is used as an autophagy inhibitor. Chloroquine also is an inhibitor of TLRs.

Formula: C₁₈H₂₆CLN₃·2(H₃PO₄)

Purity: 99.64% - ≥95%

Color and Shape: White To Slightly Yellow Crystalline Powder White Solid

Molecular weight: 515.87

Ref: TM-T0194

Chloroquine diphosphate salt

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃·2H₃PO₄

Purity: (Titration) 98.0 - 102.0 % (dried basis)

Color and Shape: White or almost white crystalline powder

Molecular weight: 515.87

Ref: 7W-GA7477

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate

Purity: ≥95%

Molecular weight: 515.87g/mol

Ref: 54-BUP17400

Chloroquine Diphosphate

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃·2H₃O₄P

Color and Shape: White To Off-White Solid

Molecular weight: 319.88 2*97.99

Ref: 4Z-C-921

Chloroquine-d5 Diphosphate

CAS: 50-63-5

Formula: C₁₈H₂₁D₅ClN₃·2H₃O₄P

Color and Shape: White To Off-White Solid

Molecular weight: 324.91 2*97.99

Ref: 4Z-C-922

Chloroquine Phosphate

CAS: 50-63-5

Color and Shape: Neat

Ref: 86-MM1055.00

Chloroquine diphosphate

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃H₃O₄P

Color and Shape: Neat

Molecular weight: 515.86

Ref: 04-C11506000

Chloroquine diphosphate

CAS: 50-63-5

Chloroquine diphosphate

Molecular weight: 515.86g/mol

Ref: 54-BISN0106

Chloroquine-d4 Phosphate Salt

Controlled Product

CAS: 1246815-14-4, 50-63-5

Applications Labelled anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product.
References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),

Formula: C₁₈H₂₂D₄ClN₃•xH₃PO₄

Color and Shape: Yellow Solid

Molecular weight: 323.9098

Ref: TR-C379967

Chloroquine diphosphate salt

CAS: 50-63-5

Stability Hygroscopic
Applications Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product.
References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),

Formula: C₁₈H₂₆ClN₃·2H₃O₄P

Color and Shape: Light Brown

Molecular weight: 515.86

Ref: TR-C379965

Chloroquine Diphosphate Salt

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃(H₃PO₄)

Molecular weight: 319.9 : 2(98.0)

Ref: ST-EA-CP-C69001

Chloroquine diphosphate

Controlled Product

CAS: 50-63-5

Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine i a schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the S-glycoprotein.

Formula: C₁₈H₃₂ClN₃O₈P₂

Color and Shape: White Off-White Powder

Molecular weight: 515.86 g/mol

Ref: 3D-FC20382

Chloroquine Diphosphate

CAS: 50-63-5

Formula: C₁₈H₃₂ClN₃O₈P₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 515.86

Ref: 10-F358020