CAS 50-63-5: (±)-Chloroquine diphosphate

Description: (±)-Chloroquine diphosphate is a synthetic compound primarily known for its use as an antimalarial agent. It belongs to the class of 4-aminoquinolines and is characterized by its ability to interfere with the growth of the malaria parasite by inhibiting heme polymerization, which is crucial for the parasite's survival. The compound exhibits a chiral nature, with two enantiomers, which can influence its pharmacological activity and side effects. In addition to its antimalarial properties, chloroquine has been investigated for potential antiviral effects and as an immunomodulatory agent in various autoimmune diseases. The diphosphate salt form enhances its solubility and stability in aqueous solutions, making it suitable for pharmaceutical formulations. Chloroquine is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in some cases. However, its use has been associated with side effects, including gastrointestinal disturbances and potential retinal toxicity with long-term use. As with any medication, careful consideration of its benefits and risks is essential in clinical settings.

Formula: C₁₈H₂₆ClN₃·2H₃O₄P

InChI: InChI=1S/C18H26ClN3.H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);(H3,1,2,3,4)

InChI key: InChIKey=AEUAEICGCMSYCQ-UHFFFAOYSA-N

SMILES: O=P(O)(O)O.ClC=1C=CC=2C(=NC=CC2NC(C)CCCN(CC)CC)C1

Synonyms:

• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹,N¹-diethyl-, phosphate (1:2)
• 3377 Rp
• 3377Rp
• 7-Chlor-4-(4-diaethylamino)-1-methylbutylamino)-chinolindiphosphat
• 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
• 7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate
• Ai3-14952
• Alermine
• Alexoquine
• Aralen diphosphate
• Aralen phosphate
• Arechin
• Avloclor
• Bemaphate
• Chingamin
• Chingamin phosphate
• Chlorochin diphosphate
• Chloroquin diphosphate
• Chloroquine bis(phosphate)
• Chloroquine dihydrogen phosphate (1:2)
• Chloroquine phosphate
• Cidoquine
• Delagil
• Gontochin phosphate
• Imagon
• Khingamin
• Maladrin
• Malaquin
• NSC 14050
• Nivaquine B
• N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine phosphate (1:2)
• Quingamine
• Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, phosphate (1:2) (8CI)
• Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, diphosphate
• Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate
• Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-, phosphate (1:2)
• Quivaclor
• Resochin
• Resoquine
• Sanoquin
• Sn 7618
• Tanakan
• Tanakan (antimalarial)
• Tresochin
• Unii-6E17K3343P
• Wr 1522
• chloroquin Phosphate
• dl-Chloroquine diphosphate
• 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2)

Chloroquine diphosphate salt, 98%

CAS: 50-63-5

Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, …

• Formula: C₁₈H₃₂ClN₃O₈P₂
• Purity: 98%
• Color and Shape: Powder or crystals or crystalline powder, White to off-white
• Molecular weight: 515.86

Chloroquine phosphate for peak identification CRS

CAS: 50-63-5

Chloroquine Phosphate

CAS: 50-63-5

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

• Formula: C₁₈H₂₆ClN₃·2H₃PO₄
• Color and Shape: Yellow Powder
• Molecular weight: 515.13532

Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)

CAS: 50-63-5

• Formula: C₁₈H₃₀ClN₃O₇P₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 497.8472

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is used as an autophagy …

• Formula: C₁₈H₂₆CLN₃·2(H₃PO₄)
• Purity: 99.64% - ≥95%
• Color and Shape: White To Slightly Yellow Crystalline Powder White Solid
• Molecular weight: 515.87

Chloroquine-d5 Diphosphate

CAS: 50-63-5

• Formula: C₁₈H₂₁D₅ClN₃·2H₃O₄P
• Color and Shape: White To Off-White Solid
• Molecular weight: 324.91 2*97.99

Chloroquine phosphate

CAS: 50-63-5

• Purity: ≥98%
• Molecular weight: 515.87g/mol

Chloroquine diphosphate salt

CAS: 50-63-5

• Formula: C₁₈H₂₆ClN₃·2H₃PO₄
• Purity: (Titration) 98.0 - 102.0 % (dried basis)
• Color and Shape: White or almost white crystalline powder
• Molecular weight: 515.87

Chloroquine Diphosphate

CAS: 50-63-5

• Formula: C₁₈H₂₆ClN₃·2H₃O₄P
• Color and Shape: White To Off-White Solid
• Molecular weight: 319.88 2*97.99

Chloroquine diphosphate salt, 98%

CAS: 50-63-5

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₁₈H₃₂ClN₃O₈P₂
• Purity: 98%
• Color and Shape: White to beige, Powder
• Molecular weight: 515.86

Chloroquine Diphosphate

CAS: 50-63-5

• Formula: C₁₈H₂₆ClN₃·2H₃PO₄
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 515.86

Chloroquine diphosphate

CAS: 50-63-5

• Formula: C₁₈H₂₆ClN₃H₃O₄P
• Color and Shape: Neat
• Molecular weight: 515.86

Chloroquine Phosphate

CAS: 50-63-5

• Formula: C₁₈H₂₆ClN₃H₃O₄P
• Color and Shape: Neat
• Molecular weight: 515.86

Chloroquine diphosphate

CAS: 50-63-5

• Molecular weight: 515.86g/mol

Chloroquine-d4 Phosphate Salt

CAS: 1246815-14-4 50-63-5

Applications Labelled anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity …

• Formula: C₁₈H₂₂D₄ClN₃•xH₃PO₄
• Color and Shape: Yellow Solid
• Molecular weight: 323.9098

Chloroquine Diphosphate Salt

CAS: 50-63-5

Stability Hygroscopic Applications Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and …

• Formula: C₁₈H₂₆ClN₃H₃O₄P
• Color and Shape: Light Brown
• Molecular weight: 515.86

Chloroquine Diphosphate

CAS: 50-63-5

• Purity: 98.0%
• Color and Shape: Solid
• Molecular weight: 515.8599853515625

Chloroquine diphosphate

CAS: 50-63-5

Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic …

• Formula: C₁₈H₃₂ClN₃O₈P₂
• Color and Shape: White Off-White Powder
• Molecular weight: 515.86 g/mol