CAS 50-65-7

Niclosamide

Description:

Niclosamide is an anthelmintic agent primarily used to treat tapeworm infections in humans and animals. It is classified as a salicylanilide and exhibits a broad spectrum of activity against various parasitic worms. The compound is characterized by its white to off-white crystalline powder form, which is practically insoluble in water but soluble in organic solvents such as ethanol and dimethyl sulfoxide. Niclosamide functions by inhibiting the oxidative phosphorylation in the mitochondria of the parasites, leading to their energy depletion and eventual death. Additionally, it has garnered interest for its potential antiviral and anticancer properties, as it has been shown to inhibit certain cellular pathways involved in viral replication and tumor growth. The substance has a relatively low toxicity profile in humans when used as directed, but it can cause side effects such as gastrointestinal disturbances. Due to its specific mode of action and low solubility, niclosamide is often formulated in combination with other agents to enhance its therapeutic efficacy.

Formula: C₁₃H₈Cl₂N₂O₄

InChI: InChI=1/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-6-8(17(20)21)2-3-10(11)15/h1-6,18H,(H,16,19)

InChI key: InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N

SMILES: C(NC1=C(Cl)C=C(N(=O)=O)C=C1)(=O)C2=C(O)C=CC(Cl)=C2

Synonyms:

• 2',5-Dichlor-4'-Nitro-Salizylsaeureanilid
• 2',5-Dichloro-4'-Nitrosalicylanilide
• 2,5-Dichloro-4-Nitrosalicylanilide
• 2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid
• 2-Hydroxy-5-Chloro-N-(2-Chloro-4-Nitrophenyl)Benzamide
• 5-Chloro-2'-Chloro-4'-Nitrosalicylanilide
• 5-Chloro-N-(2-Chloro-4-Nitrophenyl)Salicylamide
• 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
• 5-chloro-N-(2-chloro-5-nitrophenyl)-2-hydroxybenzamide
• 6-Benzylamino-2(R)-[[1-(hydroxymethyl)-propyl]amino-9-isopropylpurin]
• Bay 2353
• Bayer 2353
• Bayer 25648,Bayluscide
• Bayer 73
• Bayluscid
• Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-
• Cestocid
• Cestocide
• Devermin
• Devermine
• Fedal-Telmin
• Fenasal
• Helmiantin
• Hl 2447
• Iomesan
• Lintex
• Mansonil
• N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylamide
• NSC 178296
• Nasemo
• Niclocide
• Phenasal
• Radeverm
• Sagimid
• Salicylanilide, 2′,5-dichloro-4′-nitro-
• Sr 73
• Sulqui
• Tredemine
• Utosamide
• Vermitid
• Vermitin
• Wr 46234
• Yomesan
• Zestocarp
• NICLOSAMID
• BAYLUSCIDE
• 2’,5-dichlor-4’-nitro-salizylsaeureanilid
• 2’,5-dichloro-4’-nitro-salicylanilid
• YOMESAN(R)
• 5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamid
• NICLOSAMIDE
• BAYLUSCIDE(R)
• 2’,5-dichlor-4’-nitro-salizylsaeureanilid[german]
• MANSONIL(R)

Niclosamide

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 327.12

Ref: 3B-N1242

NICLOSAMIDE (ANHYDROUS) CRS

CAS: 50-65-7

NICLOSAMIDE (ANHYDROUS) CRS

Formula: C₁₃H₈Cl₂N₂O₄

Color and Shape: Yellow. Light Yellow. Crystals.

Molecular weight: 327.1196

Ref: 41-N0560000

Niclosamide

CAS: 50-65-7

Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.

Formula: C₁₃H₈Cl₂N₂O₄

Purity: 98.47% - 99.1%

Color and Shape: Pale Yellow Crystals Solid

Molecular weight: 327.12

Ref: TM-T0711

Niclosamide

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Purity: ≥ 98.0%

Color and Shape: Off-white to yellow powder

Molecular weight: 327.12

Ref: 7W-GA5338

Niclosamide

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Color and Shape: Yellow Solid

Molecular weight: 327.12

Ref: 4Z-N-081001

Niclosamide

CAS: 50-65-7

Niclosamide

Purity: ≥95%

Molecular weight: 327.12g/mol

Ref: 54-BUP18308

Niclosamide

Controlled Product

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Color and Shape: Neat

Molecular weight: 327.12

Ref: 86-MM0361.00

Niclosamide

Controlled Product

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Color and Shape: Neat

Molecular weight: 327.12

Ref: 04-C15510000

Niclosamide 100 µg/mL in Acetonitrile

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Color and Shape: Single Solution

Molecular weight: 327.12

Ref: 04-A15510000AL-100

Niclosamide-d6

CAS: 50-65-7

Formula: C₁₃H₂Cl₂N₂O₄D₆

Molecular weight: 333.16

Ref: 4Z-N-081002

Niclosamide-13C6

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Molecular weight: 333.16

Ref: 4Z-N-081003

Niclosamide

Controlled Product

CAS: 50-65-7

Applications Niclosamide is used as an anthelmintic drug (Cestodes).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),

Formula: C₁₃H₈Cl₂N₂O₄

Color and Shape: Neat

Molecular weight: 327.12

Ref: TR-N395500

Niclosamide

CAS: 50-65-7

Chemically a chlorinated salicylanilide, niclosamide is clinically used as an anthelmintic agent. The action of niclosamide has been proven to proceed by inhibiting the STAT3 signaling pathway. Recently, niclosamide, has been considered as an antiproliferative agent in cancer treatment, e.g. melanoma and colorectal cancer. In 2021, niclosamide has been tested for the treatment of COVID-19 patients.

Formula: C₁₃H₈Cl₂N₂O₄

Purity: Min. 98 Area-%

Color and Shape: Off-White Powder

Molecular weight: 327.12 g/mol

Ref: 3D-FN01544

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 327.12

Ref: 10-F358456

2',5-Dichloro-4'-nitrosalicylanilide

CAS: 50-65-7

Formula: C₁₃H₈Cl₂N₂O₄

Color and Shape: Solid

Molecular weight: 327.1196

Ref: IN-DA0035E0

Niclosamide

CAS: 50-65-7

Color and Shape: Neat

Ref: 61-FOR0361.00