CAS 50-66-8

6-Methylmercaptopurine

Description:

6-Methylmercaptopurine, with the CAS number 50-66-8, is a purine derivative that exhibits characteristics typical of thiol-containing compounds. It is a methylated form of mercaptopurine, which is an antimetabolite used primarily in the treatment of certain types of leukemia and autoimmune diseases. The compound features a sulfur atom in its structure, contributing to its reactivity and potential for forming disulfide bonds. It is generally a white to off-white crystalline solid, soluble in water and organic solvents, which facilitates its use in pharmaceutical formulations. The presence of the methyl group enhances its lipophilicity, potentially affecting its pharmacokinetics and bioavailability. As a thiopurine, it interferes with nucleic acid synthesis, thereby inhibiting cell proliferation, particularly in rapidly dividing cells. Safety and handling precautions are necessary due to its potential toxicity and side effects associated with its therapeutic use. Overall, 6-Methylmercaptopurine serves as an important compound in medicinal chemistry, particularly in oncology and immunology.

Formula: C₆H₆N₄S

InChI: InChI=1S/C6H6N4S/c1-11-6-4-5(8-2-7-4)9-3-10-6/h2-3H,1H3,(H,7,8,9,10)

InChI key: InChIKey=UIJIQXGRFSPYQW-UHFFFAOYSA-N

SMILES: S(C)C1=C2C(N=CN2)=NC=N1

Synonyms:

• 1H-Purine, 6-(methylthio)-
• 6-(Methylmercapto)purine
• 6-(Methylsulfanyl)-9H-purine
• 6-(Methylthio)-9H-purine
• 6-(methylsulfanyl)-5H-purine
• 6-(methylsulfanyl)-7H-purine
• 6-Methylmercaptopurine
• 9H-Purine, 6-(methylthio)-
• NSC 20105
• Purine, 6-(methylthio)-
• S-Methyl-6-mercaptopurine

6-Methylmercaptopurine

CAS: 50-66-8

Formula: C₆H₆N₄S

Purity: 97%

Color and Shape: Solid

Molecular weight: 166.2036

Ref: IN-DA0037EB

6-Methylmercaptopurine

CAS: 50-66-8

6-Methylmercaptopurine

Purity: 97%

Molecular weight: 166.2g/mol

Ref: 54-OR1028469

6-Methylmercaptopurine

Controlled Product

CAS: 50-66-8

Stability Hygroscopic
Applications Metabolite of 6-Mercaptopurine, an immunosuppressive drug used to treat leukemia.
References Chou, C., et al.: Biochem. Pharmacol., 75, 1601 (2008), Conejo-Garcia, A., et al.: Eur. J. Med. Chem., 43, 1742 (2008), Hawwa, A., et al.: Brit. J. Clin. Pharmacol., 66, 826 (2008), Askanase, A., et al.: J. Rheumatol., 36, 89 (2009),

Formula: C₆H₆N₄S

Color and Shape: White To Beige

Molecular weight: 166.20

Ref: TR-M320270

6-Methylmercaptopurine

CAS: 50-66-8

6-Methylmercaptopurine is an important metabolite of 6-methylmercaptopurine, which is a vital component of the nucleotide synthesis pathway. It is used in analytical methods to determine levels of nucleotides, as well as in biological studies for its effect on autoimmune diseases. 6-Methylmercaptopurine can inhibit replication by inhibiting the methyltransferase enzyme.

Formula: C₆H₆N₄S

Purity: Min. 95%

Color and Shape: Off-White Yellow Powder

Molecular weight: 166.2 g/mol

Ref: 3D-FM25872

6-Methylmercaptopurine extrapure, 95%

CAS: 50-66-8

Formula: C₆H₆N₄S

Purity: min.95%

Color and Shape: White to light green, Powder

Molecular weight: 166.20

Ref: SR-71512

6-(Methylthio)-9H-purine

CAS: 50-66-8

Formula: C₆H₆N₄S

Purity: 97%

Color and Shape: Solid, No data available.

Molecular weight: 166.2

Ref: 10-F069179

6-Methyl Mercaptopurine

CAS: 50-66-8

Formula: C₆H₆N₄S

Molecular weight: 166.2

Ref: ST-EA-CP-M81015