CAS 50-76-0

Dactinomycin

Description:

Dactinomycin, also known as actinomycin D, is a potent antibiotic and chemotherapeutic agent derived from the bacterium Streptomyces parvulus. It is characterized by its complex polypeptide structure, which includes a phenoxazone ring and a series of amino acids. Dactinomycin functions primarily by intercalating into DNA, thereby inhibiting RNA synthesis and disrupting protein synthesis, making it effective against various types of cancer, particularly in pediatric oncology for treating Wilms' tumor and rhabdomyosarcoma. The compound is typically administered intravenously and is known for its cytotoxic properties, which can lead to significant side effects, including myelosuppression and gastrointestinal disturbances. Dactinomycin is classified as a category D drug in pregnancy due to its potential teratogenic effects. Its stability is influenced by factors such as pH and light exposure, necessitating careful handling and storage. Overall, dactinomycin remains an important agent in the arsenal against certain malignancies, despite its associated risks and side effects.

Formula: C₆₂H₈₆N₁₂O₁₆

InChI: InChI=1/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1

Synonyms:

• 3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-
• Hbf 386
• Lyovac cosmegen
• Meractinomycin
• Oncostatin K
• X 97
• Actactinomycin A IV
• Actinomycin 7
• Actinomycin AIV
• Actinomycindioic D acid, dilactone
• Actinomycin C1
• Actinomycin Cl
• Actinomycin D
• Actinomycin I
• Actinomycin I1
• Actinomycin IV
• Actinomycin-[threo-val-pro-sar-meval]
• Actinomycin X 1
• Actinomycin X I
• Actinomyein-Theo-Val-Pro-Sar-Meval
• Acto-D
• AD
• Dilactone actinomycindioic D acid
• Dilactone actinomycin D acid
• C1
• Cosmegen
• Dactinomycin D
• Dactinomyein D
• 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
• 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxooctadecahydrocyclopenta[i][1,4,7,13]oxatriazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
• 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
• Actd
• 3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-
• Actinomycin X1
• C 1
• Chounghwamycin B
• Dactinomicina
• Dactinomycine
• Nci C04682
• Nsc 3053

Actinomycin D (1 mg/ml, DMSO)

CAS: 50-76-0

Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm?s tumor and the sarcomas. This Thermo

Formula: C₆₂H₈₆N₁₂O₁₆

Color and Shape: Liqiud, Clear Yellow to Orange to Dark Orange-Red

Molecular weight: 1255.44

Ref: 02-J67160

Actinomycin D

CAS: 50-76-0

Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues.

Formula: C₆₂H₈₆N₁₂O₁₆

Color and Shape: Crystalline powder

Molecular weight: 1255.44

Ref: 02-J60148

Dactinomycin

CAS: 50-76-0

Antibiotics nesoi

Formula: C₆₂H₈₆N₁₂O₁₆

Color and Shape: Red Crystalline Powder

Molecular weight: 1254.62847

Ref: 45-1162400

Actinomycin D

CAS: 50-76-0

Formula: C₆₂H₈₆N₁₂O₁₆

Purity: 95.0 - 103.0 % (dried basis)

Color and Shape: Red to orange crystalline powder

Molecular weight: 1255.40

Ref: 7W-GA0481

Dactinomycin

CAS: 50-76-0

Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator , inhibits transcription DNA, serving as a chemotherapy drug for cancer treatment.

Formula: C₆₂H₈₆N₁₂O₁₆

Purity: 99.70%

Color and Shape: Solid

Molecular weight: 1255.42

Ref: TM-TN9827

Actinomycin D

CAS: 50-76-0

Actinomycin D

Formula: C₆₂H₈₆N₁₂O₁₆

Purity: 99%

Color and Shape: shiny red to orange powder

Molecular weight: 1,255.42g/mol

Ref: 54-BIA0175

Actinomycin D, GlenCell™, suitable for cell culture, USP grade

CAS: 50-76-0

Formula: C₆₂H₈₆N₁₂O₁₆

Purity: 950 - 1030 μg/mg (C62H86N12O16, dried basis)

Color and Shape: Red to orange crystalline powder

Molecular weight: 1255.40

Ref: 7W-GA7901

Actinomycin D

CAS: 50-76-0

M01247 - Actinomycin D

Formula: C₆₂H₈₆N₁₂O₁₆

Purity: >98%

Color and Shape: Crystalline

Molecular weight: 1255.438

Ref: 10-M01247

Actinomycin D (Dactinomycin)

CAS: 50-76-0

Formula: C₆₂H₈₆N₁₂O₁₆

Molecular weight: 1255.44

Ref: 4Z-A-395001

Actinomycin D (Dactinomycin)

Controlled Product

CAS: 50-76-0

Applications Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Manaker, et al.: Antibiot. Ann., 55, 853 (1954), Jain, S., et al.: J. Mol. Biol., 114, 317 (1977), Nakajima, K., et al.: Pept. Chem., 19, 143 (1981), Shereda, R., et al.: J. Biol. Chem., 282, 19247 (2007),

Formula: C₆₂H₈₆N₁₂O₁₆

Color and Shape: Red

Molecular weight: 1255.42

Ref: TR-D102500

Dactinomycin

CAS: 50-76-0

Actinomycin D is an antibiotic commonly used in chemotherapy for cancer treatment, such as sarcomas, and pediatric solid tumors, Wilm’s tumor, testicular cancer, and choriocarcinoma; it is generally not very useful in antibiotic therapy. It acts as a transcription inhibitor, binding to DNA duplexes at the transcription initiation complex and preventing RNA polymerase elongation.

Formula: C₆₂H₈₆N₁₂O₁₆

Purity: Min. 95%

Color and Shape: Red Powder

Molecular weight: 1,255.42 g/mol

Ref: 3D-AD20776

Actinomycin D (AMD) ex. Streptomyces Sp., 98%

CAS: 50-76-0

Formula: C₆₂H₈₆N₁₂O₁₆

Purity: min. 98%

Color and Shape: Red, Crystalline powder

Molecular weight: 1255.45

Ref: SR-28269