CAS 50-76-0: Dactinomycin
Description:Dactinomycin, also known as actinomycin D, is a potent antibiotic and chemotherapeutic agent derived from the bacterium Streptomyces parvulus. It is characterized by its complex polypeptide structure, which includes a phenoxazone ring and a series of amino acids. Dactinomycin functions primarily by intercalating into DNA, thereby inhibiting RNA synthesis and disrupting protein synthesis, making it effective against various types of cancer, particularly in pediatric oncology for treating Wilms' tumor and rhabdomyosarcoma. The compound is typically administered intravenously and is known for its cytotoxic properties, which can lead to significant side effects, including myelosuppression and gastrointestinal disturbances. Dactinomycin is classified as a category D drug in pregnancy due to its potential teratogenic effects. Its stability is influenced by factors such as pH and light exposure, necessitating careful handling and storage. Overall, dactinomycin remains an important agent in the arsenal against certain malignancies, despite its associated risks and side effects.
Formula:C62H86N12O16
InChI:InChI=1/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
- Synonyms:
- 3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-
- Hbf 386
- Lyovac cosmegen
- Meractinomycin
- Oncostatin K
- X 97
- Actactinomycin A IV
- Actinomycin 7
- Actinomycin AIV
- Actinomycindioic D acid, dilactone
- See more synonyms
- Actinomycin C1
- Actinomycin Cl
- Actinomycin D
- Actinomycin I
- Actinomycin I1
- Actinomycin IV
- Actinomycin-[threo-val-pro-sar-meval]
- Actinomycin X 1
- Actinomycin X I
- Actinomyein-Theo-Val-Pro-Sar-Meval
- Acto-D
- AD
- Dilactone actinomycindioic D acid
- Dilactone actinomycin D acid
- C1
- Cosmegen
- Dactinomycin D
- Dactinomyein D
- 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
- 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxooctadecahydrocyclopenta[i][1,4,7,13]oxatriazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
- 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
- Actd
- 3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-
- Actinomycin X1
- C 1
- Chounghwamycin B
- Dactinomicina
- Dactinomycine
- Nci C04682
- Nsc 3053
- Stereoisomer of N,N'-[(2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-diyl)bis[carbonylimino[2-(1-hydroxyethyl)-1-oxo-2,1-ethanediyl]imino[2-(1-methylethyl)-1-oxo-2,1-ethanediyl]-1,2-pyrrolidinediylcarbonyl(methylimino)(1-oxo-2,1-ethanediyl)]]bis[N-methyl-L-valine] di-ξ-lactone
