CAS 50-76-0
:Dactinomycin
Description:
Dactinomycin, also known as actinomycin D, is a potent antibiotic and chemotherapeutic agent derived from the bacterium Streptomyces parvulus. It is characterized by its complex polypeptide structure, which includes a phenoxazone ring and a series of amino acids. Dactinomycin functions primarily by intercalating into DNA, thereby inhibiting RNA synthesis and disrupting protein synthesis, making it effective against various types of cancer, particularly in pediatric oncology for treating Wilms' tumor and rhabdomyosarcoma. The compound is typically administered intravenously and is known for its cytotoxic properties, which can lead to significant side effects, including myelosuppression and gastrointestinal disturbances. Dactinomycin is classified as a category D drug in pregnancy due to its potential teratogenic effects. Its stability is influenced by factors such as pH and light exposure, necessitating careful handling and storage. Overall, dactinomycin remains an important agent in the arsenal against certain malignancies, despite its associated risks and side effects.
Formula:C62H86N12O16
InChI:InChI=1/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
InChI key:RJURFGZVJUQBHK-IIXSONLDSA-N
SMILES:C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
Synonyms:- 3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-
- Hbf 386
- Lyovac cosmegen
- Meractinomycin
- Oncostatin K
- X 97
- Actactinomycin A IV
- Actinomycin 7
- Actinomycin AIV
- Actinomycindioic D acid, dilactone
- Actinomycin C1
- Actinomycin Cl
- Actinomycin D
- Actinomycin I
- Actinomycin I1
- Actinomycin IV
- Actinomycin-[threo-val-pro-sar-meval]
- Actinomycin X 1
- Actinomycin X I
- Actinomyein-Theo-Val-Pro-Sar-Meval
- Acto-D
- AD
- Dilactone actinomycindioic D acid
- Dilactone actinomycin D acid
- C1
- Cosmegen
- Dactinomycin D
- Dactinomyein D
- 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
- 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxooctadecahydrocyclopenta[i][1,4,7,13]oxatriazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
- 2-amino-4,6-dimethyl-3-oxo-N,N'-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
- Actd
- 3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-
- Actinomycin X1
- C 1
- Chounghwamycin B
- Dactinomicina
- Dactinomycine
- Nci C04682
- Nsc 3053
- See more synonyms
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Found 13 products.
Actinomycin D
CAS:Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues.Formula:C62H86N12O16Color and Shape:Crystalline powderMolecular weight:1255.44Actinomycin D (1 mg/ml, DMSO)
CAS:Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm?s tumor and the sarcomas. This ThermoFormula:C62H86N12O16Color and Shape:Liqiud, Clear Yellow to Orange to Dark Orange-RedMolecular weight:1255.44Dactinomycin
CAS:Antibiotics nesoiFormula:C62H86N12O16Color and Shape:Red Crystalline PowderMolecular weight:1254.62847Actinomycin D
CAS:Formula:C62H86N12O16Purity:95.0 - 103.0 % (dried basis)Color and Shape:Red to orange crystalline powderMolecular weight:1255.40Dactinomycin
CAS:Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator , inhibits transcription DNA, serving as a chemotherapy drug for cancer treatment.Formula:C62H86N12O16Purity:99.70% - 99.97%Color and Shape:Red SolidMolecular weight:1255.42Actinomycin D
CAS:Actinomycin DFormula:C62H86N12O16Purity:99%Color and Shape:Red Solid-CrystalsMolecular weight:1255.41703Actinomycin D, GlenCell™, suitable for cell culture, USP grade
CAS:Formula:C62H86N12O16Purity:950 - 1030 μg/mg (C62H86N12O16, dried basis)Color and Shape:Red to orange crystalline powderMolecular weight:1255.40Actinomycin D (Dactinomycin)
CAS:Controlled ProductApplications Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Manaker, et al.: Antibiot. Ann., 55, 853 (1954), Jain, S., et al.: J. Mol. Biol., 114, 317 (1977), Nakajima, K., et al.: Pept. Chem., 19, 143 (1981), Shereda, R., et al.: J. Biol. Chem., 282, 19247 (2007),Formula:C62H86N12O16Color and Shape:NeatMolecular weight:1255.42Dactinomycin
CAS:Actinomycin D is an antibiotic commonly used in chemotherapy for cancer treatment, such as sarcomas, and pediatric solid tumors, Wilms tumor, testicular cancer, and choriocarcinoma; it is generally not very useful in antibiotic therapy. It acts as a transcription inhibitor, binding to DNA duplexes at the transcription initiation complex and preventing RNA polymerase elongation.Formula:C62H86N12O16Purity:Min. 95%Color and Shape:Red PowderMolecular weight:1,255.42 g/molActinomycin D
CAS:M01247 - Actinomycin D
Formula:C62H86N12O16Purity:>98%Color and Shape:SolidMolecular weight:1255.438Actinomycin D (AMD) ex. Streptomyces Sp., 98%
CAS:Formula:C62H86N12O16Purity:min. 98%Color and Shape:Red, Crystalline powderMolecular weight:1255.45
