CAS 500-64-1

(+)-Kavain

Description:

(+)-Kavain, with the CAS number 500-64-1, is a naturally occurring compound classified as a kavalactone, which is derived from the roots of the kava plant (Piper methysticum). This compound is known for its psychoactive properties, often associated with relaxation and mild sedation. Chemically, (+)-Kavain is characterized by its unique structure, which includes a lactone ring, contributing to its biological activity. It is typically a colorless to pale yellow liquid with a distinctive aroma. The substance is soluble in organic solvents but has limited solubility in water. In terms of pharmacological effects, (+)-Kavain has been studied for its anxiolytic and muscle relaxant properties, making it of interest in both traditional and modern herbal medicine. However, its use is regulated in some countries due to concerns about potential hepatotoxicity with excessive consumption. Overall, (+)-Kavain exemplifies the intersection of natural products and pharmacology, highlighting the importance of understanding both its benefits and risks.

Formula: C₁₄H₁₄O₃

InChI: InChI=1S/C14H14O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-8,10,12H,9H2,1H3/b8-7+/t12-/m0/s1

InChI key: InChIKey=XEAQIWGXBXCYFX-GUOLPTJISA-N

SMILES: C(=C/C1=CC=CC=C1)\[C@H]2CC(OC)=CC(=O)O2

Synonyms:

• (+)-Kavain
• (6R)-5,6-Dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one
• (R)-(+)-Kavain
• (R)-5,6-Dihydro-4-methoxy-6-styryl-2H-pyran-2-one
• 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-, (R-(E))- (9CI)
• 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-, [R-(E)]-
• 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-, (6R)-
• 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-, (+)-
• 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-, (R)-
• 4-Methoxy-6-(beta-phenylvinyl)-5,6-dihydro-alpha-pyrone
• 4-methoxy-6-(2-phenylethenyl)-5,6-dihydro-2H-pyran-2-one
• 5-Hydroxy-3-methoxy-7-phenyl-2,6-heptadienoic acid gamma-lactone
• Gonosan
• Kawain
• Nsc 112162
• d-Kawain

Kavain

CAS: 500-64-1

Formula: C₁₄H₁₄O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 230.2592

Ref: IN-DA01DDFU

(+)-Kavain

CAS: 500-64-1

(+)-Kavain

Purity: ≥95%

Molecular weight: 230.26g/mol

Ref: 54-BUP10345

Kavain

CAS: 500-64-1

Formula: C₁₄H₁₄O₃

Molecular weight: 230.26

Ref: 7W-GY6101

Kavain

CAS: 500-64-1

Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kawain is advanced glycation endproduct inhibitors, can increase the mean life span of Caenorhabditis elegans exposed to high glucose.

Formula: C₁₄H₁₄O₃

Purity: 95%~99%

Molecular weight: 230.263

Ref: BP-BP0829

(+)-Kavain

CAS: 500-64-1

(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.

Formula: C₁₄H₁₄O₃

Purity: 97% - ≥95%

Color and Shape: White Fine Powder

Molecular weight: 230.26

Ref: TM-T4590

Kawain

Controlled Product

CAS: 500-64-1

Stability Light Sensitive
Applications Kawain is a plant extract that shows antioxidant activity through cyclooxygenase enzyme inhibition. May also be active in tumor suppression and apoptotic induction.
References Wu, D. et al.: Phytomed., 10, 309 (2003); Zi, X. et al.: Canc. Res., 65, 3479 (2005);

Formula: C₁₄H₁₄O₃

Color and Shape: Neat

Molecular weight: 230.26

Ref: TR-K145700

L-Kawain

CAS: 500-64-1

**L-Kawain** is a kavalactone compound, which is a bioactive component extracted from the root of the kava plant, Piper methysticum. This plant is traditionally found in the Pacific Islands and has been used in ceremonial drinks to promote relaxation and socialization due to its psychoactive effects.

Formula: C₁₄H₁₄O₃

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 230.26 g/mol

Ref: 3D-FK65505

Kawain

CAS: 500-64-1

Aromatic lactones used as drugs

Formula: C₁₄H₁₄O₃

Color and Shape: White Crystalline Powder

Molecular weight: 230.09429

Ref: 45-1355753