CAS 500-92-5

Proguanil

Description:

Proguanil, with the CAS number 500-92-5, is an antimalarial medication primarily used in the prevention and treatment of malaria. It is a synthetic compound belonging to the biguanide class of drugs. Proguanil acts as a prodrug, which means it is metabolized in the body to its active form, cycloguanil, that inhibits the dihydrofolate reductase enzyme in the malaria parasite, disrupting folate synthesis and ultimately hindering its growth and reproduction. The substance is typically administered orally and is known for its relatively low toxicity and good tolerability in humans. Proguanil is often used in combination with other antimalarial agents, such as atovaquone, to enhance efficacy and reduce the risk of resistance. In terms of physical properties, proguanil is a white to off-white crystalline powder that is soluble in water and has a moderate molecular weight. Its pharmacokinetics include rapid absorption and a half-life that supports once-daily dosing, making it a convenient option for malaria prophylaxis.

Formula: C₁₁H₁₆ClN₅

InChI: InChI=1/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)

InChI key: InChIKey=SSOLNOMRVKKSON-UHFFFAOYSA-N

SMILES: N(C(NC(NC(C)C)=N)=N)C1=CC=C(Cl)C=C1

Synonyms:

• 1-(4-Chlorophenyl)-5-Isopropylbiguanide
• 1-(p-Chlorophenyl)-5-isopropylbiguanide
• 1-Isopropyl-5-(4-chlorophenyl)biguanide
• Biguanide, 1-(p-chlorophenyl)-5-isopropyl-
• Bigumal
• Chlorguanid
• Chlorguanide
• Chloroguanide
• Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
• Ips 07004
• N-(4-Chlorophenyl)-N′-(1-methylethyl)imidodicarbonimidic diamide
• N1-p-Chlorophenyl-N5-isopropylbiguanide
• N¹-p-Chlorophenyl-N⁵-isopropylbiguanide
• Paludrin
• Proguanil hydrochloride
• 1-(p-chlorophenyl)-5-isopropyl-biguanid
• Aids008307
• Aids-008307
• Diguanyl (hydrochloride)
• 637-32-1 (Hydrochloride)
• ChlorguanideCl
• Chlorguanide-d6 HCl
• Chlorguanide-D6Cl
• N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
• Chlorguanide (base and/or unspecified salts)
• PROGUANIL

N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide

CAS: 500-92-5

Formula: C₁₁H₁₆ClN₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 253.7312

Ref: IN-DA00DBGF

CGP 3466B maleate

CAS: 500-92-5

CGP 3466B maleate

Purity: ≥98%

Molecular weight: 391.42g/mol

Ref: 54-BUP20864

Proguanil

CAS: 500-92-5

Proguanil

Purity: 98%

Molecular weight: 253.73g/mol

Ref: 54-OR1023875

Proguanil-d6 HCl (Chlorguanide-d6 HCl)

CAS: 500-92-5

Formula: C₁₁H₁₀ClN₅D₆·HCl

Molecular weight: 259.77 36.46

Ref: 4Z-P-468002

Proguanil (Chlorguanide)

CAS: 500-92-5

Formula: C₁₁H₁₆ClN₅

Molecular weight: 253.74

Ref: 4Z-P-468001

Proguanil

CAS: 500-92-5

Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the DHFR enzyme .

Formula: C₁₁H₁₆ClN₅

Purity: 99.6%

Color and Shape: Solid

Molecular weight: 253.73

Ref: TM-T22409

1-({amino[(4-chlorophenyl)amino]methylidene}amino)-N-(propan-2-yl)methanimidamide

CAS: 500-92-5

Purity: 98%

Molecular weight: 253.7299957

Ref: 10-F822711

Proguanil

CAS: 500-92-5

Proguanil is a drug that belongs to the class of p450 inhibitors. It is used to prevent and treat malaria, especially in areas where resistance to chloroquine has emerged. Proguanil inhibits microbial growth by inhibiting the activity of the enzyme p450, which is involved in the synthesis of cholesterol and other sterols. This inhibition prevents the production of these compounds, which are necessary for bacterial cell walls. Proguanil also blocks lymphocyte transformation and polymerase chain reactions (PCR) by binding to DNA-dependent RNA polymerase. Proguanil has been shown to be effective against infectious diseases such as malaria, infectious diarrhoea, and typhoid fever. The drug has been shown to have pharmacokinetic properties that differ depending on the dose and duration of treatment, with a high clearance rate at low doses but a lower clearance rate at higher doses. Proguanil does not bind well to albumin or human erythrocytes,

Formula: C₁₁H₁₆ClN₅

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 253.73 g/mol

Ref: 3D-FP41719