CAS 501666-85-9

1H-Indole-2-carboxamide,N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-

Description:

The chemical substance known as 1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]- is a complex organic compound characterized by its indole and benzene ring structures, which are common in many biologically active molecules. This compound features multiple functional groups, including a carboxamide and a chloromethyl group, contributing to its potential reactivity and biological activity. The presence of a methyldithio group suggests possible applications in medicinal chemistry, particularly in the development of pharmaceuticals. The stereochemistry indicated by the (1S) configuration may influence its biological interactions and efficacy. Additionally, the compound's molecular structure suggests it may exhibit properties such as solubility in organic solvents and potential interactions with biological targets, making it of interest in drug discovery and development. Further studies would be necessary to elucidate its specific biological activities and therapeutic potential.

Formula: C₃₅H₃₀ClN₅O₄S₂

DC1SMe

CAS: 501666-85-9

DC1SMe is a carbamate cytotoxic agent that binds to the phosphate group of ATP, ADP and AMP. DC1SMe has been shown to be cytotoxic in cancer cells by inhibiting the synthesis of DNA, RNA and protein. The phosphoryl group of DC1SMe can be removed by phosphatases and it can form stable adducts with glutathione or other thiols. This makes the compound more soluble in water, which allows for easier administration. It also has high affinity for cell membranes and is able to cross the blood-brain barrier.

Formula: C₃₅H₃₀ClN₅O₄S₂

Purity: Min. 95%

Molecular weight: 684.2 g/mol

Ref: 3D-BVA66685

DC1SMe

CAS: 501666-85-9

DC1, a CC-1065-like ADC cytotoxin, is used in cancer-targeting antibody-drug conjugates. DC1Sme, a derivative, has IC50s: 22-250 pm in various cancer cells.

Formula: C₃₅H₃₀ClN₅O₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 684.23

Ref: TM-T10969