CAS 5018-54-2

N4-Acetylsulfadoxine

Description:

N4-Acetylsulfadoxine is a sulfonamide antibiotic that belongs to the class of compounds known as sulfa drugs. It is characterized by its structural modification of sulfadoxine, which enhances its pharmacological properties. The compound typically exhibits antibacterial activity by inhibiting bacterial dihydropteroate synthase, an enzyme critical for folate synthesis, thereby disrupting nucleic acid synthesis in susceptible bacteria. N4-Acetylsulfadoxine is often used in combination therapies, particularly in the treatment of malaria, due to its effectiveness against Plasmodium species. The substance is generally soluble in organic solvents and has a relatively low solubility in water, which can influence its bioavailability and therapeutic efficacy. Additionally, it may exhibit side effects common to sulfonamides, such as allergic reactions or hematological disturbances. As with many pharmaceuticals, its use should be guided by clinical considerations and susceptibility patterns of the target pathogens. Proper handling and storage conditions are essential to maintain its stability and effectiveness.

Formula: C₁₄H₁₆N₄O₅S

InChI: InChI=1S/C14H16N4O5S/c1-9(19)17-10-4-6-11(7-5-10)24(20,21)18-13-12(22-2)14(23-3)16-8-15-13/h4-8H,1-3H3,(H,17,19)(H,15,16,18)

InChI key: InChIKey=PBSUUNCQTRDFCM-UHFFFAOYSA-N

SMILES: O(C)C=1C(NS(=O)(=O)C2=CC=C(NC(C)=O)C=C2)=NC=NC1OC

Synonyms:

• Acetanilide, 4′-[(5,6-dimethoxy-4-pyrimidinyl)sulfamoyl]-
• Acetanilide,4'-[(5,6-dimethoxy-4-pyrimidinyl)sulfamoyl]- (7CI,8CI)
• N-[4-[[(5,6-Dimethoxy-4-pyrimidinyl)amino]sulfonyl]phenyl]acetamide
• N4-Acetylsulfadoxine
• N⁴-Acetylsulfadoxine
• Acetamide, N-[4-[[(5,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl]phenyl]-
• Sulfadoxine N4-Acetyl
• 4'-[(5,6-DiMethoxy-4-pyriMidinyl)sulfaMoyl]acetanilide
• N4-Acetylsulfadoxin
• N(4)-acetylsulfadoxine

Sulfadoxine Impurity 3

CAS: 5018-54-2

Formula: C₁₄H₁₆N₄O₅S

Molecular weight: 352.37

Ref: 4Z-S-060007

N4-Acetyl sulfadoxine

CAS: 5018-54-2

Formula: C₁₄H₁₆N₄O₅S

Molecular weight: 352.36

Ref: ST-EA-CP-S49006

N4-Acetyl sulfadoxine

CAS: 5018-54-2

N4-Acetyl sulfadoxine is a drug that is used to treat urinary tract infections in women and children. It is also used to treat bacterial infections of the skin, lungs, and joints. N4-Acetyl sulfadoxine may be effective against prostatitis caused by E. coli or Mycoplasma pneumoniae by inhibiting the production of prostaglandins. This drug works by binding to dihydropteroate synthase, which prevents folic acid from being incorporated into the bacterial cell wall, thereby inhibiting bacterial growth.

Formula: C₁₄H₁₆N₄O₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 352.37 g/mol

Ref: 3D-IA17044

N4-Acetyl Sulfadoxine

Controlled Product

CAS: 5018-54-2

Formula: C₁₄H₁₆N₄O₅S

Color and Shape: Neat

Molecular weight: 352.37

Ref: TR-A187840