CAS 501951-42-4

SB-705498

Description:

SB-705498 is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its role as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). This inhibition is significant because PDE4 is involved in the regulation of inflammatory responses, making SB-705498 a potential candidate for treating various inflammatory diseases, including asthma and chronic obstructive pulmonary disease (COPD). The compound is characterized by its specific binding affinity to the PDE4 enzyme, which helps modulate intracellular signaling pathways. In terms of its chemical structure, SB-705498 features a unique arrangement of functional groups that contribute to its biological activity and selectivity. Additionally, it has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), which are crucial for understanding its therapeutic potential and safety profile. Overall, SB-705498 represents a promising avenue for research in anti-inflammatory therapies, although further studies are necessary to fully elucidate its efficacy and safety in clinical settings.

Formula: C₁₇H₁₆BrF₃N₄O

Synonyms:

• CS-279
• SB-705498
• SB 705498;SB705498
• Urea, N-(2-bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]-
• (R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea
• 1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)-2-pyridyl]pyrrolidin-3-yl]urea
• N-(2-Bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]urea

SB-705498

CAS: 501951-42-4

Formula: C₁₇H₁₆BrF₃N₄O

Purity: 99%

Color and Shape: Solid

Molecular weight: 429.2343

Ref: IN-DA00DABC

(R)-1-(2-Bromophenyl)-3-(1-(5-(Trifluoromethyl)Pyridin-2-Yl)Pyrrolidin-3-Yl)Urea

CAS: 501951-42-4

(R)-1-(2-Bromophenyl)-3-(1-(5-(Trifluoromethyl)Pyridin-2-Yl)Pyrrolidin-3-Yl)Urea

Purity: 99%

Molecular weight: 429.23g/mol

Ref: 54-PC108884

SB-705498

CAS: 501951-42-4

SB-705498

Purity: ≥95%

Molecular weight: 429.23g/mol

Ref: 54-BUP13448

SB-705498

CAS: 501951-42-4

SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.

Formula: C₁₇H₁₆BrF₃N₄O

Purity: 99.57% - ≥95%

Color and Shape: Solid

Molecular weight: 429.23

Ref: TM-T6660

SB 705498

CAS: 501951-42-4

Antagonist of TRPV1 cation channel

Formula: C₁₇H₁₆BrF₃N₄O

Purity: Min. 95%

Molecular weight: 429.23 g/mol

Ref: 3D-FS29861