CAS 502648-93-3

Thieno[2,3-d]pyrimidine, 6-ethyl-4-(1-piperazinyl)-, dihydrochloride

Description:

Thieno[2,3-d]pyrimidine, 6-ethyl-4-(1-piperazinyl)-, dihydrochloride is a chemical compound characterized by its unique bicyclic structure that incorporates both a thieno and pyrimidine moiety. This compound features an ethyl group at the 6-position and a piperazine substituent at the 4-position, which contributes to its potential biological activity. The presence of two hydrochloride groups indicates that the compound is a salt, enhancing its solubility in aqueous environments, which is often beneficial for pharmacological applications. Thieno[2,3-d]pyrimidines are known for their diverse biological activities, including potential roles as antitumor, antiviral, and anti-inflammatory agents. The piperazine ring is commonly associated with various pharmacological properties, including anxiolytic and antidepressant effects. Overall, this compound's structural characteristics suggest it may interact with biological targets, making it of interest in medicinal chemistry and drug development. However, specific biological activity and safety profiles would require further investigation through empirical studies.

Formula: C₁₂H₁₆N₄SClH

6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride

Controlled Product

CAS: 502648-93-3

Applications 6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride is an intermediate used in the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.
References Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012);

Formula: C₁₂H₁₆N₄S•2(HCl)

Color and Shape: Neat

Molecular weight: 248.35 + 2(36.46)

Ref: TR-E898795