CAS 503070-58-4

Vilanterol trifenatate

Description:

Vilanterol trifenatate is a long-acting beta-2 adrenergic agonist (LABA) primarily used in the management of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It functions by relaxing the smooth muscles of the airways, leading to bronchodilation and improved airflow. This compound is characterized by its prolonged duration of action, which allows for once-daily dosing, enhancing patient compliance. Vilanterol is typically administered via inhalation, often in combination with other medications, such as corticosteroids, to provide comprehensive management of respiratory symptoms. The substance is known for its favorable pharmacokinetic profile, including rapid onset and sustained effects, making it effective for both acute and chronic management of airway obstruction. Additionally, Vilanterol trifenatate has undergone extensive clinical evaluation to establish its safety and efficacy, with common side effects including headache, throat irritation, and potential cardiovascular effects, which necessitate careful monitoring in patients with pre-existing heart conditions. Overall, Vilanterol trifenatate represents a significant advancement in the therapeutic options available for respiratory diseases.

Formula: C₂₄H₃₃Cl₂NO₅·C₂₀H₁₆O₂

InChI: InChI=1S/C24H33Cl2NO5.C20H16O2/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28;21-19(22)20(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h5-9,14,24,27-30H,1-4,10-13,15-17H2;1-15H,(H,21,22)/t24-;/m0./s1

InChI key: InChIKey=KLOLZALDXGTNQE-JIDHJSLPSA-N

SMILES: [C@@H](CNCCCCCCOCCOCC1=C(Cl)C=CC=C1Cl)(O)C2=CC(CO)=C(O)C=C2.C(C(O)=O)(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

Synonyms:

• Benzeneacetic acid, α,α-diphenyl-, compd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol (1:1)
• GW 642444M
• Vilanterol triphenylacetate
• Vilanterol trifenatate
• 4-[(R)-2-[[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol triphenylacetate

Vilanterol Trifenatate

CAS: 503070-58-4

Formula: C₂₄H₃₃Cl₂NO₅·C₂₀H₁₆O₂

Color and Shape: White To Off-White Solid

Molecular weight: 486.43 288.35

Ref: 4Z-V-058001

Vilanterol Trifenatate

Controlled Product

CAS: 503070-58-4

Formula: C₂₄H₃₃Cl₂NO₅·C₂₀H₁₆O₂

Color and Shape: Neat

Molecular weight: 774.77

Ref: 86-MM3492.00

Vilanterol trifenatate

CAS: 503070-58-4

Vilanterol trifenatate is a long-acting agonist of β2-adrenoceptor (β2-AR) with inherent 24-hour activity(β2-AR, β1-AR and β3-AR pEC50s of 10.37, 6.98 and 7.36, respectively)

Formula: C₄₄H₄₉Cl₂NO₇

Purity: 99.51% - >99.99%

Color and Shape: Solid

Molecular weight: 774.77

Ref: TM-T5134

Vilanterol Trifenatate

CAS: 503070-58-4

Applications Vilanterol Trifenatate is a long-acting β2 adrenergic receptor Agonist. It demonstrates prolonged bronchodilation in subjects with asthma and COPD.
References Procopiou, P., et al.: J. Med. Chem., 53, 4522 (2010); Kempsford, R., et al.: Pulm. Pharmacol. Ther., 26, 256 (2013)

Formula: C₂₄H₃₃Cl₂NO₅·C₂₀H₁₆O₂

Color and Shape: Neat

Molecular weight: 774.77

Ref: TR-V260000

Vilanterol

Controlled Product

CAS: 503070-58-4

Please enquire for more information about Vilanterol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Ref: 3D-OV174064