CAS 503610-43-3: Rosuvastatin Lactone
Description:Rosuvastatin lactone is a chemical compound that serves as a metabolite of rosuvastatin, a widely used statin for lowering cholesterol levels. It is characterized by its lactone structure, which is a cyclic ester formed from the reaction of a hydroxy acid. The compound exhibits a high affinity for HMG-CoA reductase, the enzyme responsible for cholesterol synthesis in the liver, thereby effectively reducing low-density lipoprotein (LDL) cholesterol levels. Rosuvastatin lactone is typically less active than its parent compound, rosuvastatin, but it still contributes to the overall pharmacological effects. The compound is soluble in organic solvents and has limited solubility in water, which influences its bioavailability and pharmacokinetics. Its stability and reactivity can be affected by environmental conditions, such as pH and temperature. As with other statins, potential side effects may include muscle pain, liver enzyme alterations, and gastrointestinal disturbances, necessitating monitoring during therapy. Overall, rosuvastatin lactone plays a role in the metabolic pathway of cholesterol management and is significant in the context of cardiovascular health.
Formula:C22H26FN3O5S
InChI:InChI=1/C22H26FN3O5S/c1-13(2)20-18(10-9-17-11-16(27)12-19(28)31-17)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)32(4,29)30/h5-10,13,16-17,27H,11-12H2,1-4H3/b10-9+/t16-,17-/m1/s1
- Synonyms:
- N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide
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