CAS 503612-47-3

Apixaban

Description:

Apixaban is an oral anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. It functions as a selective inhibitor of Factor Xa, an essential enzyme in the coagulation cascade, thereby reducing the formation of blood clots. Apixaban is characterized by its high bioavailability, rapid onset of action, and predictable pharmacokinetics, which allows for fixed dosing without the need for routine monitoring of coagulation parameters. The substance is typically administered in tablet form and is well-absorbed in the gastrointestinal tract. Its metabolism primarily occurs in the liver via cytochrome P450 enzymes, and it is excreted through both renal and fecal pathways. Common side effects may include bleeding complications, which are a significant concern with anticoagulants. Overall, Apixaban represents a significant advancement in anticoagulant therapy, offering a convenient and effective option for managing thromboembolic risks.

Formula: C₂₅H₂₅N₅O₄

InChI: InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)

InChI key: InChIKey=QNZCBYKSOIHPEH-UHFFFAOYSA-N

SMILES: O=C1C=2N(N=C(C(N)=O)C2CCN1C3=CC=C(C=C3)N4C(=O)CCCC4)C5=CC=C(OC)C=C5

Synonyms:

• 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide
• 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide
• 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
• 1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-
• 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
• Apixaban
• Bms-562247
• Bms-562247-01
• Eliquis

Apixaban

CAS: 503612-47-3

Lactams, nesoi

Formula: C₂₅H₂₅N₅O₄

Color and Shape: Off-White White Solid

Molecular weight: 459.51 g/mol

Ref: 45-1040741

1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide

CAS: 503612-47-3

Formula: C₂₅H₂₅N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 459.4971

Ref: IN-DA00396M

Apixaban

CAS: 503612-47-3

Formula: C₂₅H₂₅N₅O₄

Color and Shape: Off-White Solid

Molecular weight: 459.51

Ref: 4Z-A-10201

Apixaban

CAS: 503612-47-3

Apixaban

Purity: 98%

Molecular weight: 459.5g/mol

Ref: 54-OR1029516

Apixaban

CAS: 503612-47-3

Formula: C₂₅H₂₅N₅O₄

Purity: 97.5 - 102.5 %

Color and Shape: White to off-white or pale yellow powder

Molecular weight: 459.50

Ref: 7W-GP7497

Apixaban

CAS: 503612-47-3

Apixaban

Purity: ≥98%

Molecular weight: 459.5g/mol

Ref: 54-BUP14840

Apixaban

CAS: 503612-47-3

Formula: C₂₅H₂₅N₅O₄

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 459.51

Ref: 3B-A3657

Apixaban

CAS: 503612-47-3

Formula: C₂₅H₂₅N₅O₄

Color and Shape: Neat

Molecular weight: 459.50

Ref: 86-MM3754.00

Apixaban

CAS: 503612-47-3

Apixaban (BMS-562247-01) is an orally active inhibitor of coagulation factor Xa with anticoagulant activity.

Formula: C₂₅H₂₅N₅O₄

Purity: 99.73% - 99.93%

Color and Shape: Solid

Molecular weight: 459.5

Ref: TM-T1736

Apixaban

CAS: 503612-47-3

Applications A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References Luettgen, J. M., et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T., et al.: J. Thromb. Thrombol., 31, 310 (2011); Barrett, Y. C., et al.: Thromb. Haemos., 105, 181 (2011);

Formula: C₂₅H₂₅N₅O₄

Color and Shape: White To Off-White

Molecular weight: 459.50

Ref: TR-A726700

APIXABAN

CAS: 503612-47-3

Purity: 98%

Molecular weight: 459.5060119628906

Ref: 10-F793053

Apixaban

CAS: 503612-47-3

Inhibitor of Factor Xa; anti-coagulant

Formula: C₂₅H₂₅N₅O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 459.5 g/mol

Ref: 3D-FM61539

Apixaban - Bio-X ™

CAS: 503612-47-3

Apixaban is an anticoagulant agent used for the prophylaxis of stroke and deep vein thrombosis leading to pulmonary embolism. This drug is an inhibitor of factor Xa and prothrominase. As a result, this prevents the formation of a thrombus.

Formula: C₂₅H₂₅N₅O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 459.5 g/mol

Ref: 3D-BM164185

Chloropentanamidophenyl Desmethoxy Apixaban

Controlled Product

CAS: 503612-47-3

Formula: C₂₄H₂₄ClN₅O₃

Color and Shape: Neat

Molecular weight: 465.932

Ref: TR-C726700