CAS 503612-47-3: Apixaban
Description:Apixaban is an oral anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. It functions as a selective inhibitor of Factor Xa, an essential enzyme in the coagulation cascade, thereby reducing the formation of blood clots. Apixaban is characterized by its high bioavailability, rapid onset of action, and predictable pharmacokinetics, which allows for fixed dosing without the need for routine monitoring of coagulation parameters. The substance is typically administered in tablet form and is well-absorbed in the gastrointestinal tract. Its metabolism primarily occurs in the liver via cytochrome P450 enzymes, and it is excreted through both renal and fecal pathways. Common side effects may include bleeding complications, which are a significant concern with anticoagulants. Overall, Apixaban represents a significant advancement in anticoagulant therapy, offering a convenient and effective option for managing thromboembolic risks.
Formula:C25H25N5O4
InChI:InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
InChI key:InChIKey=QNZCBYKSOIHPEH-UHFFFAOYSA-N
SMILES:O=C(N)C1=NN(C2=CC=C(OC)C=C2)C=3C(=O)N(C4=CC=C(C=C4)N5C(=O)CCCC5)CCC13
- Synonyms:
- 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide
- 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide
- 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
- 1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-
- 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- Apixaban
- Bms-562247
- Bms-562247-01
- Eliquis