CAS 5051-22-9
:(+)-Propranolol
Description:
(+)-Propranolol is a non-selective beta-adrenergic antagonist, commonly used in the treatment of various cardiovascular conditions, including hypertension, anxiety, and migraine prophylaxis. It is characterized by its ability to block the effects of epinephrine and norepinephrine on beta receptors, leading to decreased heart rate and blood pressure. The compound has a chiral center, and the (+) designation indicates its specific enantiomer, which is pharmacologically active. Propranolol is typically administered orally and is well-absorbed, although it undergoes significant first-pass metabolism in the liver. Its chemical structure includes a naphthalene ring, an isopropanolamine side chain, and it exhibits lipophilic properties, allowing it to cross the blood-brain barrier. Common side effects may include fatigue, dizziness, and gastrointestinal disturbances. Due to its diverse therapeutic applications, propranolol has become a widely studied and utilized medication in clinical practice.
Formula:C16H21NO2
InChI:InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
InChI key:InChIKey=AQHHHDLHHXJYJD-CQSZACIVSA-N
SMILES:O(C[C@@H](CNC(C)C)O)C=1C2=C(C=CC1)C=CC=C2
Synonyms:- (+)-(R)-Propranolol
- (+)-Propranolol
- (2R)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol
- (2R)-Propranolol
- 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, (+)-
- 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, (R)-
- Dexpropranolol
- Dextropropranolol
- d-Propranolol
- 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, (2R)-
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