CAS 5060-51-5

6-hydroxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one

Description:

6-Hydroxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one, with the CAS number 5060-51-5, is a chemical compound belonging to the quinazolinone class, which is characterized by a fused bicyclic structure containing a quinazoline moiety. This compound typically exhibits a range of biological activities, making it of interest in medicinal chemistry. Its structure includes a hydroxyl group, a methyl group, and a phenyl substituent, which can influence its solubility, reactivity, and interaction with biological targets. The presence of the hydroxyl group may enhance its potential for hydrogen bonding, while the methyl groups can affect lipophilicity and steric properties. Quinazolinones are often studied for their pharmacological properties, including anti-inflammatory, analgesic, and anticancer activities. The specific characteristics, such as melting point, solubility, and spectral data, would depend on the compound's purity and the conditions under which it is analyzed. Overall, this compound represents a significant area of research in the development of therapeutic agents.

Formula: C₁₆H₁₄N₂O₂

InChI: InChI=1/C16H14N2O2/c1-10-5-3-4-6-15(10)18-11(2)17-14-8-7-12(19)9-13(14)16(18)20/h3-9,19H,1-2H3

SMILES: Cc1ccccc1n1c(C)nc2ccc(cc2c1=O)O

Synonyms:

• 4(3H)-Quinazolinone, 6-hydroxy-2-methyl-3-(2-methylphenyl)-
• 6-Hydroxy-2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

6-Hydroxy Methaqualone

CAS: 5060-51-5

Applications A metabolite Methaqualone (M225900). Controlled substance.
References Ericsson, O., et al.: Acta Pharmaceut. Suecica, 15, 81 (1978), Wilson, K., et al.: Eur. J. Drug Metab. Pharmacokinet., 9, 301 (1984),

Formula: C₁₆H₁₄N₂O₂

Color and Shape: Neat

Molecular weight: 266.29

Ref: TR-H946815

6-Hydroxy methaqualone

Controlled Product

CAS: 5060-51-5

6-Hydroxy methaqualone is a chiral drug that is metabolized by the liver to its active form, which is 6-hydroxy methaqualone. This active form inhibits the enzyme CYP3A4 and has a potent inhibitory effect on the activity of other enzymes in the liver, such as CYP2D6. 6-Hydroxy methaqualone has been shown to be an effective inhibitor of CYP2D6 in human liver microsomes. The elimination phase of 6-hydroxy methaqualone is longer than its halflife and can be found in urine samples for up to 12 hours after ingestion. Analytical methods for this drug are based on gas chromatography and mass spectrometry (GC/MS).

Formula: C₁₆H₁₄N₂O₂

Purity: Min. 95%

Molecular weight: 266.29 g/mol

Ref: 3D-FH24046