CAS 50704-46-6

O6-Ethyldeoxyguanosine

Description:

O6-Ethyldeoxyguanosine is a modified nucleoside that is derived from deoxyguanosine, featuring an ethyl group at the O6 position of the guanine base. This modification can influence the nucleoside's properties, including its stability, reactivity, and interactions with DNA and RNA. The presence of the ethyl group may affect hydrogen bonding and base pairing, potentially impacting the molecule's role in nucleic acid synthesis and function. O6-Ethyldeoxyguanosine is of interest in biochemical and pharmacological research, particularly in studies related to mutagenesis, DNA repair mechanisms, and the development of novel therapeutic agents. Its CAS number, 50704-46-6, allows for precise identification in chemical databases and literature. As a synthetic analog, it may also serve as a tool for investigating the effects of alkylation on genetic material, providing insights into the mechanisms of action of certain chemotherapeutic agents and the biological consequences of DNA modifications. Overall, O6-Ethyldeoxyguanosine represents a significant compound in the study of nucleic acid chemistry and its implications in health and disease.

Formula: C₁₂H₁₇N₅O₄

InChI: InChI=1S/C12H17N5O4/c1-2-20-11-9-10(15-12(13)16-11)17(5-14-9)8-3-6(19)7(4-18)21-8/h5-8,18-19H,2-4H2,1H3,(H2,13,15,16)/t6-,7+,8+/m0/s1

InChI key: InChIKey=AQRYUWBBKDNOHV-XLPZGREQSA-N

SMILES: O(CC)C1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)=NC(N)=N1

Synonyms:

• 2′-Deoxy-6-O-ethylguanosine
• 9H-Purin-2-amine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-ethoxy-
• Guanosine, 2′-deoxy-6-O-ethyl-
• NSC 240591
• O⁶-Ethyl-2′-deoxyguanosine
• O⁶-Ethyldeoxyguanosine
• O6-Ethyl-2′-deoxyguanosine
• O6-Ethyldeoxyguanosine

O6-Ethyl-2’-deoxyguanosine

Controlled Product

CAS: 50704-46-6

Formula: C₁₂H₁₇N₅O₄

Color and Shape: Neat

Molecular weight: 295.295

Ref: TR-E913800

O6-Ethyl-2’-deoxyguanosine

CAS: 50704-46-6

base ethylated deoxy-guanosine nucleoside

Formula: C₁₂H₁₇N₅O₄

Purity: Min. 95%

Molecular weight: 295.29 g/mol

Ref: 3D-ACA70446

O6-Ethyl-2’-deoxyguanosine-d5

Controlled Product

CAS: 50704-46-6

Applications Labelled O6-Ethyl-2’-deoxyguanosine exists due to a mutation occurring in guanine. It is a genotoxic compound which has been identified as a carcinogenic compound.
References Kato, K. et al.: Mutat. Res. Gen. Tox. Env., 721, 21 (2011); Upton, D. et al.: Chem. Res. Tox., 20, 164 (2007);

Formula: C₁₂H₁₂D₅N₅O₄

Color and Shape: Neat

Molecular weight: 302.341

Ref: TR-E913802