CAS 5072-26-4

Buthionine sulfoximine

Description:

Buthionine sulfoximine (BSO) is a synthetic compound primarily recognized for its role as an inhibitor of the enzyme gamma-glutamylcysteine synthetase, which is crucial in the synthesis of glutathione, a vital antioxidant in cells. With the CAS number 5072-26-4, BSO is characterized by its ability to deplete intracellular levels of glutathione, thereby increasing oxidative stress within cells. This property has made it a valuable tool in research, particularly in studies related to cancer therapy, neurodegenerative diseases, and the effects of oxidative stress. BSO is typically administered in a laboratory setting and is not used as a therapeutic agent in clinical practice due to its potential toxicity and side effects. The compound is usually presented as a white to off-white solid and is soluble in water and various organic solvents. Its chemical structure includes a sulfoximine functional group, which is responsible for its biological activity. Overall, BSO serves as an important reagent in biochemical research, particularly in the context of oxidative stress and cellular metabolism.

Formula: C₈H₁₈N₂O₃S

InChI: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)

InChI key: InChIKey=KJQFBVYMGADDTQ-UHFFFAOYSA-N

SMILES: S(CCC(C(O)=O)N)(CCCC)(=N)=O

Synonyms:

• Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
• Sulfoximine, S-(3-amino-3-carboxypropyl)-S-butyl-
• 2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
• Sulfoximine, 3-amino-3-carboxypropyl butyl
• Butionine sulfoximine

Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-

CAS: 5072-26-4

Formula: C₈H₁₈N₂O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 222.3051

Ref: IN-DA00I93K

DL-Buthionine-(S,R)-sulfoximine

CAS: 5072-26-4

DL-Buthionine-(S,R)-sulfoximine

Purity: ≥98%

Molecular weight: 222.31g/mol

Ref: 54-BUP14058

DL-Buthionine-(S,R)-sulfoximine

CAS: 5072-26-4

Formula: CH₃(CH₂)₃S(O)NH)CH₂CH₂CH(NH₂)CO₂H

Purity: ≥ 98.5%

Color and Shape: White powder

Molecular weight: 222.31

Ref: 7W-GL8169

DL-Buthionine-(S,R)-sulphoximine

CAS: 5072-26-4

DL-Buthionine-(S,R)-sulphoximine

Formula: C₈H₁₈N₂O₃S

Purity: 98%

Color and Shape: white solid

Molecular weight: 222.31g/mol

Ref: 54-OR9025T

DL-Buthionine-(S,R)-sulfoximine

CAS: 5072-26-4

DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.

Formula: C₈H₁₈N₂O₃S

Purity: 98% - 99.64%

Color and Shape: White Fine Powder

Molecular weight: 222.31

Ref: TM-T7708

D,L-Buthionine-(S,R)-sulfoximine

Controlled Product

CAS: 5072-26-4

Applications A potent and specific inhibitor of alpha-glutamyl cysteine synthetase.
References Griffith, O.W., et al.: J. Biol. Chem., 254, 16, 7558 (1979), Griffith, O.W., et al.: Methods Enzymol., 77, 59 (1981),

Formula: C₈H₁₈N₂O₃S

Color and Shape: Neat

Molecular weight: 222.31

Ref: TR-B690250